Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：多文化間精神医学会  

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：日本スポーツ精神医学会  

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：中央大学保健体育研究所  

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：中央大学保健体育研究所  

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：中央大学保健体育研究所  

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Language：Japanese   Publishing type：Research paper (bulletin of university, research institution)   Publisher：Tha Institute of health and Sports Science Chuo University  

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Language：Japanese   Publishing type：Research paper (bulletin of university, research institution)   Publisher：Insitute of Business Reserach Chuo University  

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Language：Japanese   Publishing type：Research paper (bulletin of university, research institution)   Publisher：中央大学保健体育研究所  

CiNii Books

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Language：Japanese   Publishing type：Research paper (bulletin of university, research institution)   Publisher：中央大学保健体育研究所  

CiNii Books

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Language：Japanese   Publishing type：Research paper (bulletin of university, research institution)   Publisher：The Insitute of Health and Sports Science Chuo University  

CiNii Books

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Language：Japanese   Publishing type：Research paper (bulletin of university, research institution)   Publisher：中央大学保健体育研究所  

CiNii Books

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Language：Japanese   Publishing type：Research paper (scientific journal)  

CiNii Books

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：中央大学保健体育教科運営委員会  

CiNii Books

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Other Link： http://ir.c.chuo-u.ac.jp/repository/search/item/md/rsc/p/8503/

Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：日本スポーツ精神医学会  

CiNii Books

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：中央大学保健体育研究所  

CiNii Books

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：中央大学保健体育研究所  

CiNii Books

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：中央大学保健体育研究所  

CiNii Books

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：中央大学保健体育研究所  

CiNii Books

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Other Link： http://search.jamas.or.jp/link/ui/2014353881

Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：中央大学保健体育研究所  

CiNii Books

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：世論時報社  

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Language：Japanese   Publisher：日本スポーツ精神医学会  

CiNii Books

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Other Link： http://search.jamas.or.jp/link/ui/2010214031

Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：日本スポーツ精神医学会  

CiNii Books

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Other Link： http://search.jamas.or.jp/link/ui/2008046864

Authorship：Lead author   Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：日本精神分析学会  

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：BLACKWELL PUBLISHING ASIA  

Norepinephrine (NE) is considered to play a permissive role in the occurrence of rapid eye movement (REM) sleep. Clonidine is an NE alpha-2-receptor agonist, which has been considered to act mainly on the autoreceptors of presynaptic noradrenergic neurons to reduce their release of NE. However, previous studies of clonidine effects on REM sleep have produced controversial results and the effects of clonidine remain uncertain. To clarify the pharmacological effects of clonidine on human sleep, the sleep electroencephalograms (EEG) recorded from 15 young normal subjects after a single administration of either a low (25 mug) or medium (150 mug) dose of clonidine were examined, and fast Fourier transformation (FFT) spectral analyses of the C3-A2 EEG were performed. Low-dose clonidine significantly increased the amount of REM sleep and decreased the amount of non-REM (NREM) sleep during the second one-third of the drug nights compared to the corresponding hours of baseline night recordings. In contrast, medium-dose clonidine significantly decreased REM and increased NREM on drug nights compared to baseline nights in the entire night. The opposite actions of low and medium doses of clonidine on NREM-REM proportion may indicate that low-dose clonidine mainly affects the alpha-2-receptors on locus coeruleus-NE neurons presynaptically, reducing the release of NE, whereas medium-dose clonidine acts more post-synaptically.

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Authorship：Lead author   Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：日本社会精神医学会  

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：BLACKWELL PUBLISHING LTD  

To investigate the pathophysiology of narcoleptic patients' sleep in detail, we analysed and compared the whole-night polysomnograms of narcoleptic patients and normal human subjects. Eight drug-naive narcoleptic patients and eight age-matched normal volunteers underwent polysomnography (PSG) on two consecutive nights. In addition to conventional visual scoring of the polysomnograms, rapid eye movement (REM)-density and electroencephalograph (EEG) power spectra analyses were also performed. Sleep onset REM periods and fragmented nocturnal sleep were observed as expected in our narcoleptic patients. In the narcoleptic patients, REM period duration across the night did not show the significant increasing trend that is usually observed in normal subjects. In all narcoleptic patient REM periods, eye movement densities were significantly increased. The power spectra of narcoleptic REM sleep significantly increased between 0.3 and 0.9 Hz and decreased between 1.0 and 5.4 Hz. Further analysis revealed that non-rapid eye movement (NREM) period duration and the declining trend of delta power density in the narcoleptic patients were not significantly different from the normal subjects. Compared with normal subjects, the power spectra of narcoleptic NREM sleep increased in the 1.0-1.4 Hz and 11.0-11.9 Hz frequency bands, and decreased in a 24.0-26.9 Hz frequency band. Thus, increased EEG delta and decreased beta power densities were commonly observed in both the NREM and REM sleep of the narcoleptic patients, although the decrease in beta power during REM sleep was not statistically significant. Our visual analysis revealed fragmented nocturnal sleep and increased phasic REM components in the narcoleptic patients, which suggest the disturbance of sleep maintenance mechanism(s) and excessive effects of the mechanism(s) underlying eye movement activities during REM sleep in narcolepsy. Spectral analysis revealed significant increases in delta components and decreases in beta components, which suggest decreased activity in central arousal mechanisms. These characteristics lead us to hypothesize that two countervailing mechanisms underlie narcoleptic sleep pathology.

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：WILEY  

It is known that autonomic nervous activities change in correspondence with sleep stages. However, the characteristics of continuous fluctuations in nocturnal autonomic nerve tone have not been clarified in detail. The study aimed to determine the possible correlation between the electroencephalogram (EEG) and autonomic nervous activities, and to clarify in detail the nocturnal fluctuations in autonomic nerve activities. Overnight EEGs and electrocardiograms of seven healthy males were obtained. These EEGs were analyzed by fast Fourier transformation algorithm to extract delta, sigma and beta power. Heart rate and heart rate variability (HRV) were calculated in consecutive 5-min epochs. The HRV indices of low frequency (LF), high frequency (HF) and LF/HF ratio were calculated from the spectral analysis of R-R intervals. The sleep stages were manually scored according to Rechtschaffen and Kales' criteria. Low frequency and LF/HF were significantly lower during non-rapid eye movement (NREM) than REM, and were lower in stages 3 and 4 than in stages 1 and 2. Furthermore, delta EEG showed inverse correlations with LF (r = - 0.44, P < 0.001) and LF/HF (r = - 0.41, P < 0.001). In contrast, HF differed neither between REM and NREM nor among NREM sleep stages. Detailed analysis revealed that correlation was evident from the first to third NREM, but not in the fourth and fifth NREM. Delta EEG power showed negative correlations with LF and LF/HF, suggesting that sympathetic nervous activities continuously fluctuate in accordance with sleep deepening and lightening.

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Authorship：Corresponding author   Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：日本精神神経学会  

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER SCIENCE INC  

Background: Among 15 monozygotic twin pairs described in the literature, only four pairs were considered to be concordant There is no derailed report of HLA-DRB1*1501/DQBI*0602 positive monozygotic twins concordant for narcolepsy, with marked difference in the age of onset.
Methods: We compared a pair of female narcoleptic twins clinically.
Results: Diagnosis of narcolepsy and monozygosity of the twins were confirmed. The second-born twin demonstrated a typical course of narcolepsy, whereas the first-born twin had a very late onset of recurrent daytime sleep episodes at age 45 and cataplexy at age 50 years, which was apparently triggered by chronic emotional stresses and sleep insufficiency.
Conclusions: The atypical course of narcolepsy in the first-bent twin supports the multifactorial model for the development of narcolepsy. It was noted that cataplexy was preceded by sustained polyphasic sleep conditions. Our observation implies that the unaffected co-twins in discordant pairs could develop narcolepsy in stressful situations later in their lives. (C) 2001 Society of Biological Psychiatry.

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Authorship：Corresponding author   Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：日本醸造協会  

CiNii Books

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Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER SCIENCE INC  

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Authorship：Lead author   Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：日本醗酵工学会  

To breed a new brewing yeast suitable for high-temperature fermentation, protoplast fusion was done between a sake yeast, Saccharomyces cerevisiae Kyokai no. 7,and a wild yeast, Saccharomyces cerevisiae 1031R-2,which can produce ethanol quickly at 40℃. Five stable fusants were isolated, and physiological studies, showed that two were tetraploid. The ability of fermentation of the fusants at 40℃ were superior to Kyokai no. 7 but inferior to 1031R-2. Kyokai no. 7 produced a weak acid-like off-flavor, and 1031R-2 and the fusants produced it more strongly. Thus strains that produced ethanol quickly with little off-flavor were not found among the fusants.Spores from AM2,one of the tetraploid fusants, were isolated with a micro-manipulator, and their fermentability at 40℃ and production of off-flavor were examined. Of 96 spores isolated, 55 germinated. Kyokai no. 7 had few spores, and the germination of spores from 1031R-2 was lower than that of AM2. The fermentability examination of 55 segregants showed that they produced 2% to 6% ethanol. Ethanol production of two diploid segregants, AM2-17B and AM2-18C, was close to that of 1031R-2,and the off-flavor of the two strains was not strong.The protoplast fusion and segregation method we used was useful for breeding of a new brewing yeast.

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Other Link： http://dl.ndl.go.jp/info:ndljp/pid/10544952

Authorship：Corresponding author   Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：日本醸造協会  

CiNii Books

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Authorship：Corresponding author   Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：日本醸造協会  

CiNii Books

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Other Link： http://search.jamas.or.jp/link/ui/1985178258

Language：English   Publishing type：Research paper (scientific journal)   Publisher：AMER SOC ENOLOGY VITICULTURE  

Web of Science

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Language：Japanese   Book type：Textbook, survey, introduction

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Language：Japanese   Book type：Scholarly book

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Total pages：368   Responsible for pages：5   Language：Japanese   Book type：Scholarly book

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Language：Japanese   Book type：Scholarly book

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Total pages：350   Responsible for pages：50   Language：Japanese   Book type：Scholarly book

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Total pages：274   Responsible for pages：30   Language：Japanese   Book type：Scholarly book

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Responsible for pages：136-144   Language：Japanese   Book type：Scholarly book

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Language：Japanese   Presentation type：Poster presentation  

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Language：Japanese   Presentation type：Oral presentation (general)  

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Language：Japanese   Presentation type：Oral presentation (general)  

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Language：Japanese   Presentation type：Oral presentation (general)  

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Language：Japanese   Presentation type：Oral presentation (general)  

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Language：Japanese   Presentation type：Oral presentation (general)  

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Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

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Language：Japanese   Presentation type：Oral presentation (general)  

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Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

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Language：Japanese   Presentation type：Oral presentation (general)  

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Language：English   Presentation type：Oral presentation (general)  

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Language：English   Presentation type：Oral presentation (general)  

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Language：English   Presentation type：Oral presentation (general)  

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Language：English   Presentation type：Oral presentation (general)  

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Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

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Language：Japanese   Presentation type：Oral presentation (general)  

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Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

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Language：Japanese   Presentation type：Oral presentation (general)  

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Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

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Language：Japanese   Presentation type：Oral presentation (general)  

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Language：Japanese   Presentation type：Oral presentation (general)  

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Language：Japanese   Presentation type：Oral presentation (general)  

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