Updated on 2025/06/06

写真a

 
IWASAKI Arihiro
 
Organization
Faculty of Science and Engineering Associate Professor
Other responsible organization
Applied Chemistry Course of Graduate School of Science and Engineering, Master's Program
Contact information
The inquiry by e-mail is 《here》
Homepage
https://sites.google.com/g.chuo-u.ac.jp/bioorganic/
External link

Degree

  • 博士（理学） ( 慶應義塾大学 )

  • 修士（理学） ( 慶應義塾大学 )

Education

  • 2016.3
     

    Keio University   doctor course   completed

  • 2009.3
     

    Keio University   master course   completed

  • 2007.3
     

    Keio University   graduated

Research History

  • 2023.4 - Now

    Chuo University   Faculty of Science and Engineering Department of Applied Chemistry   Associate Professor

  • 2022.4 - 2023.3

    Keio University   Faculty of Science and Technology Department of Chemistry   Senior Assistant Professor

  • 2017.4 - 2022.3

    Keio University   Faculty of Science and Technology Department of Chemistry   Assistant Professor

  • 2015.4 - 2017.3

    Keio University   理工学部化学科   助教（有期）

  • 2014.4 - 2015.3

    慶應義塾大学大学院   理工学研究科   助教（有期・研究奨励）

  • 2009 - 2013.3

    リアル化学株式会社   開発部開発課

▼display all

Professional Memberships

  • 2022.7 - Now

    日本菌学会

  • 2016.4 - Now

    有機合成化学協会

  • 2016.4 - Now

    毒素シンポジウム

  • 2016.4 - Now

    日本ケミカルバイオロジー学会

  • 2009.4 - Now

    日本化学会

Research Interests

  • 海洋天然物化学

Research Areas

  • Nanotechnology/Materials / Chemistry and chemical methodology of biomolecules

Papers

  • Anti-leukemia activity of the ethyl acetate extract from Gynostemma pentaphyllum (Thunb.) leaf against FLT3-overexpressing AML cells and its phytochemical characterization Reviewed

    Khin Khin Gyi, Songyot Anuchapreeda, Nutjeera Intasai, Montree Tungjai, Siriporn Okonogi, Arihiro Iwasaki, Toyonobu Usuki, Singkome Tima

    BMC Complementary Medicine and Therapies   25 ( 1 )   2025.5

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    Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Abstract

    Background

    Gynostemma pentaphyllum (Thunb.), a traditional adaptogenic herb, is known for its bioactive components with potential anti-cancer properties. Acute myeloid leukemia (AML) progression is significantly influenced by Feline McDonough Sarcoma (FMS)-like tyrosine kinase 3 (FLT3) signaling, while Wilms’ tumor 1 (WT1) serves as a key prognostic marker. This study investigates the anti-leukemia activities of active G. pentaphyllum leaf extracts and their components, focusing on the inhibition of FLT3 and WT1 activity.

    Methods

    G. pentaphyllum extracts were prepared through maceration, yielding three crude fractional extracts. The cytotoxicity of the extracts was screened against various leukemia cell lines using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. The most cytotoxic extract was further fractionated and purified via column chromatography. The anti-proliferative and apoptotic induction activities of the active extract and its fraction were evaluated through cell cycle and apoptosis analyses using flow cytometry. Changes in mitochondrial membrane potential (ΔΨm) were assessed by spectrofluorometry. To confirm anti-leukemia activity, the expression levels of FLT3, WT1 and apoptotic-related protein were analyzed using Western blotting. The major active compounds within the active fractions were identified and characterized using Electrospray Ionization Mass Spectrometry (ESI-MS) and Nuclear Magnetic Resonance (NMR) spectroscopy.

    Results

    The ethyl acetate fractional extract (F-EtOAc) demonstrated the highest cytotoxicity, particularly against FLT3-overexpressing EoL-1 (IC50 = 40.82 ± 0.8 µg/mL) and MV4-11 (IC50 = 35.54 ± 4.1 µg/mL) AML cell lines. Fraction F10 was identified as the most active fraction, significantly inhibited FLT3 and WT1 protein expression and induced G0/G1 cell cycle arrest in a dose-dependent manner. Additionally, F10 induced dose-dependent apoptosis through disruption of ΔΨm, p53 up-regulation and caspase-3 activation. Further purification of F10 identified dehydrovomifoliol as its major bioactive compound.

    Conclusion

    These findings suggest that the ethyl acetate extract of G. pentaphyllum contains bioactive compounds with anti-leukemia potential, warranting further investigation to evaluate its efficacy against AML.

    Clinical trial number

    Not applicable.

    DOI： 10.1186/s12906-025-04903-0

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    Other Link： https://link.springer.com/article/10.1186/s12906-025-04903-0/fulltext.html

  • Hedopeptolide, a NO Production Inhibitor from the Marine Cyanobacterium Okeania sp. Reviewed

    Shunya Tojo, Noriyuki Natsume, Taiki Niino, Arihiro Iwasaki, Kiyotake Suenaga, Osamu Ohno, Toshiaki Teruya

    Journal of Natural Products   88 ( 4 )   1023 - 1029   2025.3

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    Publishing type：Research paper (scientific journal)   Publisher：American Chemical Society (ACS)  

    DOI： 10.1021/acs.jnatprod.5c00095

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  • Fatuamide A, a Hybrid PKS/NRPS Metallophore from a Leptolyngbya sp. Marine Cyanobacterium Collected in American Samoa. Reviewed International coauthorship International journal

    Kelsey L Alexander, C Benjamin Naman, Arihiro Iwasaki, Alfonso Mangoni, Tiago Leao, Raphael Reher, Daniel Petras, Hyunwoo Kim, Eva Ternon, Eduardo J E Caro-Diaz, Evgenia Glukhov, Jana A Mitrevska, Nicole E Avalon, Brendan M Duggan, Lena Gerwick, William H Gerwick

    Journal of natural products   88 ( 2 )   322 - 335   2025.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    A structurally novel metabolite, fatuamide A (1), was discovered from a laboratory cultured strain of the marine cyanobacterium Leptolyngbya sp., collected from Faga'itua Bay, American Samoa. A bioassay-guided approach using NCI-H460 human lung cancer cells directed the isolation of fatuamide A, which was obtained from the most cytotoxic fraction. The planar structure of fatuamide A was elucidated by integrated NMR and MS/MS analysis, and a combination of bioinformatic and computational approaches was used to deduce the absolute configuration at its eight stereocenters. A putative hybrid PKS/NRPS biosynthetic gene cluster responsible for fatuamide A production was identified from the sequenced genomic DNA of the cultured cyanobacterium. The biosynthetic gene cluster possessed elements that suggested fatuamide A binds metals, and this metallophore property was demonstrated by native metabolomics and indicated a preference for binding copper. The producing strain was found to be highly resistant to toxicity from elevated copper concentrations in culture media.

    DOI： 10.1021/acs.jnatprod.4c01051

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  • Isolation and Total Synthesis of Ukabamide, an Antitrypanosomal Lipopeptide from a Marine Moorena sp. Cyanobacterium. Reviewed International journal

    Masahiro Hagihara, Naoaki Kurisawa, Arihiro Iwasaki, Raimu Taguchi, Ghulam Jeelani, Tomoyoshi Nozaki, Kiyotake Suenaga

    Organic letters   2025.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    Human African trypanosomiasis (HAT) is one of the most lethal of the neglected tropical diseases. While the discovery of a novel antitrypanosomal drug is highly desired, the creation of a superior lead compound is challenging. Herein we report ukabamide (1), which was isolated from a marine Moorena sp. cyanobacterium, as a selective and potent antitrypanosomal lipopeptide (IC50 = 34 ± 18 nM against Trypanosoma brucei rhodesiense). Its structure was elucidated by spectroscopic analyses and degradation reactions and confirmed by total synthesis. In addition, we prepared two modified analogs and revealed the importance of the fatty acid chain length for biological activity. These findings may provide design guidelines for an antitrypanosomal drug.

    DOI： 10.1021/acs.orglett.4c04832

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  • The Bioorganic Study of Iezoside: A Novel SERCA Inhibitor from the Marine Cyanobacterium Reviewed

    Naoaki Kurisawa, Arihiro Iwasaki, Kiyotake Suenaga

    Journal of Synthetic Organic Chemistry, Japan   82 ( 11 )   1107 - 1116   2024.11

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    Publishing type：Research paper (scientific journal)   Publisher：The Society of Synthetic Organic Chemistry, Japan  

    DOI： 10.5059/yukigoseikyokaishi.82.1107

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  • Toxicity of the marine glycosidic macrolides, polycavernoside E and akunolides, from Okinawan cyanobacterium Okeania sp. in mice Reviewed

    Mari Yotsu-Yamashita, Kairi Umeda, Arihiro Iwasaki, Kiyotake Suenaga

    Toxicon   108122 - 108122   2024.10

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    Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.toxicon.2024.108122

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  • Allelopathic Activity of Leaf Wastes of Liriodendron tulipifera for Sustainable Management

    HISASHI KATO-NOGICHI, Kota Hayashi, Arihiro Iwasaki, Kiyotake Suenaga

    Applied Sciences   2024.9

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.3390/app14188437

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  • Amantamide C, an Antitrypanosomal Linear Lipopeptide from a Marine Okeania sp. Cyanobacterium. Reviewed International journal

    Natsumi Watanabe, Ghulam Jeelani, Tomoyoshi Nozaki, Arihiro Iwasaki

    ACS omega   9 ( 34 )   36795 - 36801   2024.8

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    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    Amantamides are lipopeptides that act as selective CXC chemokine receptor 7 agonists and modulate spontaneous calcium oscillations in primary cultured neocortical neurons. We isolated a new analog of amantamides, amantamide C, from marine Okeania sp. cyanobacterium collected in Japan and established its structure based on NMR and MS/MS analyses, and degradation reactions. In addition, we evaluated the biological activity of amantamide C and revealed novel biological features of amantamide-type compounds.

    DOI： 10.1021/acsomega.4c05909

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  • Pemuchiamides A and B, Proline-Rich Linear Lipopeptides, Isolated from a Marine Hormoscilla sp. Cyanobacterium. Reviewed International journal

    Kensuke Irie, Ghulam Jeelani, Tomoyoshi Nozaki, Arihiro Iwasaki

    Journal of natural products   2024.8

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    Pemuchiamides A and B (1 and 2) were isolated from a marine Hormoscilla sp. cyanobacterium collected from Pemuchi Beach on Hateruma Island, Japan. Although 1 and 2 existed as a complex mixture of rotamers in chloroform-d, detailed analyses of their 2D NMR and tandem mass spectra revealed their planar structures, respectively. The absolute configurations of 1 and 2 were established via the degradation and derivatization reactions. Pemuchiamide A (1) exhibited potent growth-inhibitory activity against Trypanosoma brucei rhodesiense, the causative organism of African sleeping sickness, while 2 showed 10-fold weaker activity than 1. This result indicates that the presence of a hydroxy group at the C-3 position of the 4-aminobutanoic acid moiety negatively affects antitrypanosomal activity.

    DOI： 10.1021/acs.jnatprod.4c00733

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  • Wajeepeptin, a Cytotoxic and Antitrypanosomal Cyclic Depsipeptide from a Marine Moorena sp. Cyanobacterium. Reviewed International journal

    Naoaki Kurisawa, Ghulam Jeelani, Tomoyoshi Nozaki, Adnan Luthfi Agusta, Kiyotake Suenaga, Arihiro Iwasaki

    Journal of natural products   87 ( 7 )   1838 - 1843   2024.7

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    Here, we report wajeepeptin (1), a new cyclic depsipeptide isolated from a marine Moorena sp. cyanobacterium. The structure was elucidated by a combination of spectroscopic analyses, X-ray diffraction analysis, and degradation reactions. Wajeepeptin (1) showed moderate cytotoxicity (IC50 = 3.7 μM against HeLa cells) and potent antitrypanosomal activity (IC50 = 0.73 ± 0.14 μM against Trypanosoma brucei rhodesiense).

    DOI： 10.1021/acs.jnatprod.4c00499

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  • Structure-Activity Relationship Studies on Iezoside, a Highly Potent Ca2+ ATPase Inhibitor Reviewed

    Naoaki Kurisawa, Kazuya Teranuma, Akari Noto, Arihiro Iwasaki, Yoshiki Kabashima, Rie Nakajima, Chikashi Toyoshima, Kiyotake Suenaga

    Bulletin of the Chemical Society of Japan   2024.7

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    Publishing type：Research paper (scientific journal)   Publisher：Oxford University Press (OUP)  

    Abstract

    Iezoside (1a) is a novel, potent sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) inhibitor from marine cyanobacterium. This paper describes the synthesis of comprehensive iezoside (1a) analogs containing C18/19 diastereomers, simplified analogs without the peptide unit, and aglycones. Evaluations of the antiproliferative activities against cancer cells and SERCA inhibitory activities of the synthesized analogs revealed how the absolute configurations at C18/19, peptide, and the sugar unit contribute to each bioactivity.Ca2+ ATPase (SERCA) inhibitor, Structure-activity relationship, Marine natural products

    DOI： 10.1093/bulcsj/uoae070

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  • Allelopathy and Allelochemicals in Chamaecyparis obtusa Leaves for the Development of Sustainable Agriculture

    HISASHI KATO-NOGICHI, Kumpei Mori, Arihiro Iwasaki, Kiyotake Suenaga

    Agronomy   2024.7

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.3390/agronomy14071557

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  • Total Synthesis of Bipenicilisorin and Assignment of the Absolute Configuration. Reviewed International journal

    Eigo Fukuda, Ibuki Fujiwara, Shoki Maruno, Kaiki Motomura, Seiya Endo, Arihiro Iwasaki, Tatsuya Fukuta, Atsushi Nakayama, Tetsuro Shinada

    Journal of natural products   2024.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    The first total synthesis of bipenicilisorin (1) isolated from Penicillium chrysogenum SCSIO 41001 via its monomer natural product, penicilisorin (2), was achieved. Penicilisorin was synthesized in four steps from a o-bromobenzaldehyde derivative via the Pd-catalyzed one-pot fluorocarbonylation/lactonization/β-elimination cascade reaction. Iodination of penicilisorin gave 7-iodopenicilisorin which was dimerized by Pd-catalyzed homodimerization to provide (±)-bipenicilisorin. The unknown absolute configuration of naturally occurring (+)-bipenicilisorin was examined by optical resolution of the (±)-synthetic bipenicilisorin and a comparison of experimental and theoretical electronic circular dichroism (ECD) spectra. These results support the absolute configuration of the natural product to be Sa. A cytotoxic activity test of (+)-and (-)-bipenicilisorin using A549 cells revealed that (+)-1 has a lower IC50 value than (-)-1.

    DOI： 10.1021/acs.jnatprod.4c00114

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  • Kagimminols A and B, Cembrene-Type Diterpenes from an Okeania sp. Marine Cyanobacterium. Reviewed International journal

    Akira Ebihara, Raimu Taguchi, Ghulam Jeelani, Tomoyoshi Nozaki, Kiyotake Suenaga, Arihiro Iwasaki

    Journal of natural products   2024.2

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    Kagimminols A (1) and B (2), new cembrene-type diterpenoids, were isolated from an Okeania sp. marine cyanobacterium. By combining DP4 analysis with an efficient NMR chemical shift calculation protocol, we clarified the relative configurations of 1 and 2 without consuming precious natural products. We determined the absolute configurations by a comparison of theoretical electronic circular dichroism (ECD) spectra with experimental spectra, and the absolute configuration of 1 was verified experimentally. Finally, we found that 1 and 2 showed selective growth-inhibitory activity against the causative agent of human African trypanosomiasis. This study exemplifies that computational chemistry is an efficient tool for clarifying the configurations of natural products possessing tautomers in equilibrium.

    DOI： 10.1021/acs.jnatprod.4c00056

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  • Enhancing Human Health and Wellbeing through Sustainably and Equitably Unlocking a Healthy Ocean's Potential. Reviewed International journal

    Lora E Fleming, Philip J Landrigan, Oliver S Ashford, Ella M Whitman, Amy Swift, William H Gerwick, Johanna J Heymans, Christina C Hicks, Karyn Morrissey, Mathew P White, Lota Alcantara-Creencia, Karen A Alexander, Thomas Astell-Burt, Roberto G S Berlinck, Philippa J Cohen, Richard Hixson, Mohammad Mahmudul Islam, Arihiro Iwasaki, Radisti A Praptiwi, Hervé Raps, Jan Yves Remy, Georgina Sowman, Eva Ternon, Torsten Thiele, Shakuntala H Thilsted, Jacqueline Uku, Stephanie Ockenden, Pushpam Kumar

    Annals of global health   90 ( 1 )   41 - 41   2024

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    Language：English   Publishing type：Research paper (scientific journal)  

    A healthy ocean is essential for human health, and yet the links between the ocean and human health are often overlooked. By providing new medicines, technologies, energy, foods, recreation, and inspiration, the ocean has the potential to enhance human health and wellbeing. However, climate change, pollution, biodiversity loss, and inequity threaten both ocean and human health. Sustainable realisation of the ocean's health benefits will require overcoming these challenges through equitable partnerships, enforcement of laws and treaties, robust monitoring, and use of metrics that assess both the ocean's natural capital and human wellbeing. Achieving this will require an explicit focus on human rights, equity, sustainability, and social justice. In addition to highlighting the potential unique role of the healthcare sector, we offer science-based recommendations to protect both ocean health and human health, and we highlight the unique potential of the healthcare sector tolead this effort.

    DOI： 10.5334/aogh.4471

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  • Isolation and structure determination of a new analog of polycavernosides from marine Okeania sp. cyanobacterium. Invited Reviewed International journal

    Kairi Umeda, Naoaki Kurisawa, Ghulam Jeelani, Tomoyoshi Nozaki, Kiyotake Suenaga, Arihiro Iwasaki

    Beilstein journal of organic chemistry   20   645 - 652   2024

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    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    Polycavernoside E (1), a new polycavernoside analog, was isolated from a marine Okeania sp. cyanobacterium. The relative configuration was elucidated primarily by analyzing the two dimensional nuclear magnetism resonance (2D NMR) data. The absolute configuration was clarified by comparing the electronic circular dichroism (ECD) data of 1 with those of known analogs. Polycavernoside E (1) exhibited moderate antitrypanosomal activity against Trypanosoma brucei rhodesiense. Furthermore, the isolation of polycavernoside E (1) from marine cyanobacteria provides additional evidence that marine cyanobacteria, and not red algae, are responsible for the biosynthesis of polycavernosides.

    DOI： 10.3762/bjoc.20.57

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  • Isolation and Structure Determination of Akunolides, Macrolide Glycosides from a Marine Okeania sp. Cyanobacterium. Reviewed International journal

    Kairi Umeda, Arihiro Iwasaki, Raimu Taguchi, Naoaki Kurisawa, Ghulam Jeelani, Tomoyoshi Nozaki, Kiyotake Suenaga

    Journal of natural products   86 ( 11 )   2529 - 2538   2023.11

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    Akunolides A (1), B (2), C (3), and D (4), new macrolide glycosides, were isolated from a marine Okeania sp. cyanobacterium. Their structures were elucidated by spectroscopic analyses and derivatization reactions. Akunolides A-D (1-4) are classified as 16-membered macrolide glycosides, which are relatively rare structures for marine cyanobacterium-derived natural products. Akunolides A-D (1-4) showed moderate antitrypanosomal activities against Trypanosoma brucei rhodesiense, with IC50 values ranging from 11 to 14 μM. Furthermore, akunolides A (1) and C (3) exhibited no cytotoxicity against normal human WI-38 cells even at a concentration of 150 μM.

    DOI： 10.1021/acs.jnatprod.3c00742

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  • Total Synthesis of Ikoamide, a Highly N-Methylated Antimalarial Lipopeptide. Reviewed International journal

    Yung-Han Lo, Arihiro Iwasaki, Kiyotake Suenaga

    The Journal of organic chemistry   88 ( 15 )   10565 - 10573   2023.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    Ikoamide (1) is a highly N-methylated antimalarial lipopeptide that was isolated from a marine cyanobacterium, an Okeania sp. in 2018, which shows strong antimalarial activity without cytotoxicity against human cancer cell lines. To establish a synthetic method for obtaining enough ikoamide for its biological evaluations, we have established a total synthesis of ikoamide. The synthetic method presented here lays the foundation for the development of novel ikoamide analogues, which may lead to a discovery of pharmaceutically unique antimalarial drug leads.

    DOI： 10.1021/acs.joc.3c00595

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  • Differentiation-Promoting Effects of Okeaniamides A and B from an Okeania sp. Marine Cyanobacterium on Preadipocytes. Reviewed International journal

    Kaori Ozaki, Yuka Asato, Noriyuki Natsume, Shunya Tojo, Shimpei Sumimoto, Arihiro Iwasaki, Kiyotake Suenaga, Toshiaki Teruya

    Journal of natural products   86 ( 6 )   1564 - 1570   2023.6

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    The linear lipopeptides okeaniamide A (1) and okeaniamide B (2) were isolated from an Okeania sp. marine cyanobacterium collected in Okinawa. The structures of these compounds were established by spectroscopic analyses, and the absolute configurations were elucidated based on a combination of chemical degradations, Marfey's analysis, and derivatization reactions. Okeaniamide A (1) and okeaniamide B (2) dose-dependently promoted the differentiation of mouse 3T3-L1 preadipocytes in the presence of insulin.

    DOI： 10.1021/acs.jnatprod.3c00256

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  • Isolation of Hennaminal and Isolation and Total Synthesis of Hennamide, Pyrrolinone Compounds from the Marine Cyanobacterium Rivularia sp. Reviewed International journal

    Hiroki Takahashi, Arihiro Iwasaki, Akira Ebihara, Raimu Taguchi, Ghulam Jeelani, Tomoyoshi Nozaki, Kiyotake Suenaga

    Organic letters   25 ( 14 )   2400 - 2404   2023.4

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    Two new natural products were isolated from the marine cyanobacterium Rivularia sp. collected in Japan. Hennaminal possesses a very rare functional group, β,β-diamino unsaturated ketone, which has only been found in bohemamine-type natural products so far. Hennamide possesses a reactive N-acyl pyrrolinone moiety, which induces self-dimerization. The isolation and structure determination supported by computational chemistry and total synthesis, as well as the antitrypanosomal activities of hennaminal and hennamide are described.

    DOI： 10.1021/acs.orglett.3c00421

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  • Isolation and Identification of Plant-Growth Inhibitory Constituents from Polygonum chinense Linn and Evaluation of Their Bioherbicidal Potential International journal

    Thang Lam Lun, Arihiro Iwasaki, Kiyotake Suenaga, Hisashi Kato-Noguchi

    Plants   12 ( 7 )   2023.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.3390/plants12071577

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  • Unique Initiation and Termination Mechanisms Involved in the Biosynthesis of a Hybrid Polyketide-Nonribosomal Peptide Lyngbyapeptin B Produced by the Marine Cyanobacterium Moorena bouillonii. Reviewed International journal

    Fumitaka Kudo, Takuji Chikuma, Mizuki Nambu, Taichi Chisuga, Shimpei Sumimoto, Arihiro Iwasaki, Kiyotake Suenaga, Akimasa Miyanaga, Tadashi Eguchi

    ACS chemical biology   18 ( 4 )   875 - 883   2023.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    Lyngbyapeptin B is a hybrid polyketide-nonribosomal peptide isolated from particular marine cyanobacteria. In this report, we carried out genome sequence analysis of a producer cyanobacterium Moorena bouillonii to understand the biosynthetic mechanisms that generate the unique structural features of lyngbyapeptin B, including the (E)-3-methoxy-2-butenoyl starter unit and the C-terminal thiazole moiety. We identified a putative lyngbyapeptin B biosynthetic (lynB) gene cluster comprising nine open reading frames that include two polyketide synthases (PKSs: LynB1 and LynB2), four nonribosomal peptide synthetases (NRPSs: LynB3, LynB4, LynB5, and LynB6), a putative nonheme diiron oxygenase (LynB7), a type II thioesterase (LynB8), and a hypothetical protein (LynB9). In vitro enzymatic analysis of LynB2 with methyltransferase (MT) and acyl carrier protein (ACP) domains revealed that the LynB2 MT domain (LynB2-MT) catalyzes O-methylation of the acetoacetyl-LynB2 ACP domain (LynB2-ACP) to yield (E)-3-methoxy-2-butenoyl-LynB2-ACP. In addition, in vitro enzymatic analysis of LynB7 revealed that LynB7 catalyzes the oxidative decarboxylation of (4R)-2-methyl-2-thiazoline-4-carboxylic acid to yield 2-methylthiazole in the presence of Fe2+ and molecular oxygen. This result indicates that LynB7 is responsible for the last post-NRPS modification to give the C-terminal thiazole moiety in lyngbyapeptin B biosynthesis. Overall, we identified and characterized a new marine cyanobacterial hybrid PKS-NRPS biosynthetic gene cluster for lyngbyapeptin B production, revealing two unique enzymatic logics.

    DOI： 10.1021/acschembio.3c00011

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  • Total Synthesis of Caldorazole, a Potent Mitochondrial Respiratory Chain Inhibitor without Chiral Centers. International journal

    Yuta Miyamoto, Arihiro Iwasaki, Haruka Fujimura, Chihiro Kudo, Naoaki Kurisawa, Osamu Ohno, Kiyotake Suenaga

    The Journal of organic chemistry   88 ( 5 )   3208 - 3216   2023.3

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    Caldorazole (1) is a novel polyketide that was isolated from a marine cyanobacterium in 2022. It is a unique natural product that exhibits potent inhibitory activity against mitochondrial respiratory chain complex I despite having no chiral centers. To establish a method for obtaining caldorazole without relying on biological resources and for constructing a useful synthetic route for studies of its structure-activity relationship, we achieved the first total synthesis of caldorazole using a convergent synthetic route.

    DOI： 10.1021/acs.joc.2c03007

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  • Allelopathic Substances of Osmanthus spp. for Developing Sustainable Agriculture

    Hisashi Kato-Noguchi, Yuri Hamada, Misuzu Kojima, Sanae Kumagai, Arihiro Iwasaki, Kiyotake Suenaga

    Plants   12 ( 2 )   2023.1

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.3390/plants12020376

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  • Assessment of the Phytotoxic Potential of Dregea volubilis (L.f.) Benth. ex Hook.f. and Identification of its Phytotoxic Substances for Weed Control

    Ei Han Kyaw, Arihiro Iwasaki, Kiyotake Suenaga, Hisashi Kato-Noguchi

    Agriculture (Switzerland)   12 ( 11 )   2022.11

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.3390/agriculture12111826

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  • Two Allelopathic Substances from Plumbago rosea Stem Extracts and Their Allelopathic Effects

    Thang Lam Lun, Arihiro Iwasaki, Kiyotake Suenaga, Hisashi Kato-Noguchi

    Agronomy   12 ( 9 )   2022.9

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.3390/agronomy12092020

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  • Phytotoxic Effects of Senna garrettiana and Identification of Phytotoxic Substances for the Development of Bioherbicides

    Ramida Krumsri, Arihiro Iwasaki, Kiyotake Suenaga, Hisashi Kato-Noguchi

    Agriculture (Switzerland)   12 ( 9 )   2022.9

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.3390/agriculture12091338

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  • Allelopathic Activity of a Novel Compound, 5,6-Dihydrogen-11 alpha-O-acetyl-12 beta-O-tigloyl-17 beta-marsdenin, and a Known Steroidal Glycoside from the Leaves of Marsdenia tenacissima (Roxb.) Moon Reviewed

    Seinn Moh Moh, Arihiro Iwasaki, Kiyotake Suenaga, Hisashi Kato-Noguchi

    AGRONOMY-BASEL   12 ( 7 )   2022.7

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    DOI： 10.3390/agronomy12071536

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  • Isolation and Total Synthesis of Beru'amide, an Antitrypanosomal Polyketide from a Marine Cyanobacterium Okeania sp. International journal

    Raimu Taguchi, Arihiro Iwasaki, Akira Ebihara, Ghulam Jeelani, Tomoyoshi Nozaki, Kiyotake Suenaga

    ORGANIC LETTERS   24 ( 25 )   4710 - 4714   2022.6

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    DOI： 10.1021/acs.orglett.2c02013

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  • Isolation of Caldorazole, a Thiazole-Containing Polyketide with Selective Cytotoxicity under Glucose-Restricted Conditions International journal

    Osamu Ohno, Arihiro Iwasaki, Kyouhei Same, Chihiro Kudo, Erika Aida, Kazuya Sugiura, Shimpei Sumimoto, Toshiaki Teruya, Etsu Tashiro, Siro Simizu, Kenji Matsuno, Masaya Imoto, Kiyotake Suenaga

    ORGANIC LETTERS   24 ( 25 )   4547 - 4551   2022.6

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    DOI： 10.1021/acs.orglett.2c01566

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  • Structural Determination, Total Synthesis, and Biological Activity of Iezoside, a Highly Potent Ca2+-ATPase Inhibitor from the Marine Cyanobacterium Leptochromothrix valpauliae Reviewed International journal

    Naoaki Kurisawa, Arihiro Iwasaki, Kazuya Teranuma, Shingo Dan, Chikashi Toyoshima, Masaru Hashimoto, Kiyotake Suenaga

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   144 ( 24 )   11019 - 11032   2022.6

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    DOI： 10.1021/jacs.2c04459

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  • Targeted Discovery of Amantamide B, an Ion Channel Modulating Nonapeptide from a South China Sea Oscillatoria Cyanobacterium International journal

    Te Li, Chuchu Xi, Yiyi Yu, Ning Wang, Xiao Wang, Arihiro Iwasaki, Fang Fang, Lijian Ding, Shuang Li, Weiyan Zhang, Ye Yuan, Tingting Wang, Xiaojun Yan, Shan He, Zhengyu Cao, C. Benjamin Naman

    JOURNAL OF NATURAL PRODUCTS   85 ( 3 )   493 - 500   2022.3

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    DOI： 10.1021/acs.jnatprod.1c00983

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  • Allelopathy of the Medicinal Plant Dregea volubilis (L.f.) Benth. ex Hook.f. and Its Phytotoxic Substances with Allelopathic Activity

    Ei Han Kyaw, Arihiro Iwasaki, Kiyotake Suenaga, Hisashi Kato-Noguchi

    AGRONOMY-BASEL   12 ( 2 )   2022.2

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    DOI： 10.3390/agronomy12020303

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  • Assessment of Allelopathic Potential of Senna garrettiana Leaves and Identification of Potent Phytotoxic Substances

    Ramida Krumsri, Arihiro Iwasaki, Kiyotake Suenaga, Hisashi Kato-Noguchi

    AGRONOMY-BASEL   12 ( 1 )   2022.1

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    DOI： 10.3390/agronomy12010139

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  • Allelopathy and Allelopathic Substances of Fossil Tree Species Metasequoia glyptostroboides

    Yuki Matuda, Arihiro Iwasaki, Kiyotake Suenaga, Hisashi Kato-Noguchi

    AGRONOMY-BASEL   12 ( 1 )   2022.1

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    DOI： 10.3390/agronomy12010083

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  • Odookeanynes A and B, Acetylene-Containing Lipopeptides from an Okeania sp. Marine Cyanobacterium International journal

    Aki Yamano, Yuka Asato, Noriyuki Natsume, Arihiro Iwasaki, Kiyotake Suenaga, Toshiaki Teruya

    JOURNAL OF NATURAL PRODUCTS   85 ( 1 )   169 - 175   2022.1

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    DOI： 10.1021/acs.jnatprod.1c00915

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  • Phytotoxic activity of Clerodendrum indicum (L.) Kuntze and its potential phytotoxic substance

    Ei Han Kyaw, Arihiro Iwasaki, Kiyotake Suenaga, Hisashi Kato-Noguchi

    EMIRATES JOURNAL OF FOOD AND AGRICULTURE   33 ( 10 )   884 - 892   2021.10

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    DOI： 10.9755/ejfa.2021.v33.i10.2779

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  • First Total Synthesis and Structure-Activity Relationship of Iheyamide A, an Antitrypanosomal Linear Peptide Isolated from a Dapis sp. Marine Cyanobacterium. International journal

    Arihiro Iwasaki, Kazuya Teranuma, Naoaki Kurisawa, Yulia Rahmawati, Ghulam Jeelani, Tomoyoshi Nozaki, William H Gerwick, Kiyotake Suenaga

    Journal of natural products   84 ( 9 )   2587 - 2593   2021.9

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    DOI： 10.1021/acs.jnatprod.1c00792

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  • Isolation and Total Synthesis of Kinenzoline, an Antitrypanosomal Linear Depsipeptide Isolated from a Marine Salileptolyngbya sp. Cyanobacterium. International journal

    Naoaki Kurisawa, Keisuke Otomo, Arihiro Iwasaki, Ghulam Jeelani, Tomoyoshi Nozaki, Kiyotake Suenaga

    The Journal of organic chemistry   86 ( 18 )   12528 - 12536   2021.9

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    DOI： 10.1021/acs.joc.1c00817

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  • Isolation and Total Synthesis of Bromoiesol sulfates, Antitrypanosomal arylethers from a Salileptolyngbya sp. Marine Cyanobacterium. International journal

    Akira Ebihara, Arihiro Iwasaki, Youhei Miura, Ghulam Jeelani, Tomoyoshi Nozaki, Kiyotake Suenaga

    The Journal of organic chemistry   86 ( 17 )   11763 - 11770   2021.9

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    DOI： 10.1021/acs.joc.1c01214

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  • Phytotoxicity of the novel compound 3-hydroxy-4-oxo-β-dehydroionol and compound 3-oxo-α-ionone from Albizia richardiana (Voigt.) King & Prain

    Kawsar Hossen, Arihiro Iwasaki, Kiyotake Suenaga, Hisashi Kato-Noguchi

    Environmental Technology and Innovation   23   2021.8

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    DOI： 10.1016/j.eti.2021.101779

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  • Metabolomic Characterization of a cf. Neolyngbya Cyanobacterium from the South China Sea Reveals Wenchangamide A, a Lipopeptide with In Vitro Apoptotic Potential in Colon Cancer Cells. International journal

    Lijian Ding, Rinat Bar-Shalom, Dikla Aharonovich, Naoaki Kurisawa, Gaurav Patial, Shuang Li, Shan He, Xiaojun Yan, Arihiro Iwasaki, Kiyotake Suenaga, Chengcong Zhu, Haixi Luo, Fuli Tian, Fuad Fares, C Benjamin Naman, Tal Luzzatto-Knaan

    Marine drugs   19 ( 7 )   2021.7

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    DOI： 10.3390/md19070397

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  • Lingaoamide, a cyclic heptapeptide from a Chinese freshwater cyanobacterium Oscillatoria sp.

    Arihiro Iwasaki, Naoaki Kurisawa, Tingting Wang, Xiaohui Li, Haixi Luo, Chengcong Zhu, Gaurav Patial, Xiaojun Yan, Shan He, Tal Luzzatto-Knaan, Fuli Tian, C. Benjamin Naman, Kiyotake Suenaga

    TETRAHEDRON LETTERS   75   2021.7

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    DOI： 10.1016/j.tetlet.2021.153214

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  • Motobamide, an Antitrypanosomal Cyclic Peptide from a Leptolyngbya sp. Marine Cyanobacterium. International journal

    Hiroki Takahashi, Arihiro Iwasaki, Naoaki Kurisawa, Ryota Suzuki, Ghulam Jeelani, Teruhiko Matsubara, Toshinori Sato, Tomoyoshi Nozaki, Kiyotake Suenaga

    Journal of natural products   84 ( 5 )   1649 - 1655   2021.5

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    DOI： 10.1021/acs.jnatprod.1c00234

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  • Correction to Iheyamides A-C, Antitrypanosomal Linear Peptides Isolated from a Marine Dapis sp. Cyanobacterium. International journal

    Naoaki Kurisawa, Arihiro Iwasaki, Ghulam Jeelani, Tomoyoshi Nozaki, Kiyotake Suenaga

    Journal of natural products   84 ( 4 )   1423 - 1423   2021.4

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  • Komesuamide and odopenicillatamide, two linear lipopeptides from the marine cyanobacterium Caldora penicillata

    Kaori Ozaki, Atsuhide Jinno, Noriyuki Natsume, Shimpei Sumimoto, Arihiro Iwasaki, Kiyotake Suenaga, Toshiaki Teruya

    TETRAHEDRON   85   2021.4

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    DOI： 10.1016/j.tet.2021.131969

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  • Isolation and identification of three potential phytotoxic compounds from Chrysopogon aciculatus (Retz.) Trin

    Md Shafiqul Islam, Farhana Zaman, Arihiro Iwasaki, Kiyotake Suenaga, Hisashi Kato-Noguchi

    Acta Physiologiae Plantarum   43 ( 4 )   2021.4

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    DOI： 10.1007/s11738-021-03221-5

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  • Identification and Application of Bioactive Compounds from Garcinia xanthochymus Hook. for Weed Management

    Md Mahfuzur Rob, Kawsar Hossen, Mst. Rokeya Khatun, Keitaro Iwasaki, Arihiro Iwasaki, Kiyotake Suenaga, HISASHI KATO-NOGICHI

    Applied Sciences   11 ( 5 )   2021.3

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    DOI： 10.3390/app11052264

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  • Bioorganic Study of New Natural Products Isolated from Marine Cyanobacteria

    Arihiro Iwasaki, Kiyotake Suenaga

    JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN   79 ( 2 )   133 - 144   2021.2

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  • Phytotoxic Activity and Growth Inhibitory Substances from Albizia richardiana (Voigt.) King & Prain

    Kawsar Hossen, Arihiro Iwasaki, Kiyotake Suenaga, HISASHI KATO-NOGICHI

    Applied Sciences   11 ( 4 )   2021.2

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    DOI： 10.3390/app11041455

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  • Isolation, Structure Determination, and Total Synthesis of Hoshinoamide C, an Antiparasitic Lipopeptide from the Marine Cyanobacterium Caldora penicillata. International journal

    Arihiro Iwasaki, Keisuke Ohtomo, Naoaki Kurisawa, Ikuma Shiota, Yulia Rahmawati, Ghulam Jeelani, Tomoyoshi Nozaki, Kiyotake Suenaga

    Journal of natural products   84 ( 1 )   126 - 135   2021.1

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    DOI： 10.1021/acs.jnatprod.0c01209

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  • Allelopathic Potential and Active Substances from Wedelia Chinensis (Osbeck). International journal

    Kawsar Hossen, Krishna Rany Das, Shun Okada, Arihiro Iwasaki, Kiyotake Suenaga, Hisashi Kato-Noguchi

    Foods (Basel, Switzerland)   9 ( 11 )   2020.11

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    DOI： 10.3390/foods9111591

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  • Dactylospenes A-E, Sesterterpenes from the Marine Sponge Dactylospongia elegans. Reviewed International journal

    Hao-Bing Yu, Bin-Bin Gu, Arihiro Iwasaki, Wen-Li Jiang, Andrew Ecker, Shu-Ping Wang, Fan Yang, Hou-Wen Lin

    Marine drugs   18 ( 10 )   2020.9

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    DOI： 10.3390/md18100491

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  • Potential use of Schumannianthus dichotomus waste: the phytotoxic activity of the waste and its identified compounds. Reviewed International journal

    Md Mahfuzur Rob, Arihiro Iwasaki, Kiyotake Suenaga, Kaori Ozaki, Toshiaki Teruya, Hisashi Kato-Noguchi

    Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes   55 ( 12 )   1 - 7   2020.9

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    DOI： 10.1080/03601234.2020.1822716

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  • Assessment of allelopathic potential of Dalbergia cochinchinensis Pierre and its growth inhibitory substance

    Ramida Krumsri, Arihiro Iwasaki, Kiyotake Suenaga, Hisashi Kato-Noguchi

    EMIRATES JOURNAL OF FOOD AND AGRICULTURE   32 ( 7 )   513 - 521   2020.7

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    DOI： 10.9755/ejfa.2020.v32.i7.2130

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  • Irijimasides A-E, Macrolide Glycosides from an Okeania sp. Marine Cyanobacterium. Reviewed International journal

    Aki Yamano, Noriyuki Natsume, Miki Yamada, Shimpei Sumimoto, Arihiro Iwasaki, Kiyotake Suenaga, Toshiaki Teruya

    Journal of natural products   83 ( 5 )   1585 - 1591   2020.5

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    DOI： 10.1021/acs.jnatprod.0c00042

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  • Iheyamides A-C, Antitrypanosomal Linear Peptides Isolated from a Marine Dapis sp. Cyanobacterium. Reviewed International journal

    Naoaki Kurisawa, Arihiro Iwasaki, Ghulam Jeelani, Tomoyoshi Nozaki, Kiyotake Suenaga

    Journal of natural products   83 ( 5 )   1684 - 1690   2020.5

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    DOI： 10.1021/acs.jnatprod.0c00250

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  • A kaurene-type novel phytotoxic substance in Wedelia chinensis

    Krishna Rany Das, Arihiro Iwasaki, Kiyotake Suenaga, Hisashi Kato-Noguchi

    Tetrahedron Letters   61 ( 11 )   2020.3

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    DOI： 10.1016/j.tetlet.2020.151600

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  • Ikoamide, an Antimalarial Lipopeptide from an Okeania sp. Marine Cyanobacterium. Reviewed International journal

    Keitaro Iwasaki, Arihiro Iwasaki, Shimpei Sumimoto, Teruhiko Matsubara, Toshinori Sato, Tomoyoshi Nozaki, Yumiko Saito-Nakano, Kiyotake Suenaga

    Journal of natural products   83 ( 2 )   481 - 488   2020.2

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    DOI： 10.1021/acs.jnatprod.9b01147

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  • Phytotoxic Activity and Identification of Phytotoxic Substances from Schumannianthus dichotomus. Reviewed International journal

    Md Mahfuzur Rob, Kawsar Hossen, Arihiro Iwasaki, Kiyotake Suenaga, Hisashi Kato-Noguchi

    Plants (Basel, Switzerland)   9 ( 1 )   2020.1

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    DOI： 10.3390/plants9010102

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  • Allelopathic potential and identification of two allelopathic substances in Eleocharis atropurpurea

    Zaman, F., Iwasaki, A., Suenaga, K., Kato-Noguchi, H.

    Plant Biosystems   155 ( 3 )   510 - 516   2020

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    DOI： 10.1080/11263504.2020.1762779

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  • Tree Fern Cyathea lepifera May Survive by Its Phytotoxic Property. Reviewed International journal

    Noriyuki Ida, Arihiro Iwasaki, Toshiaki Teruya, Kiyotake Suenaga, Hisashi Kato-Noguchi

    Plants (Basel, Switzerland)   9 ( 1 )   2019.12

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    DOI： 10.3390/plants9010046

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  • Isolation and Total Synthesis of Mabuniamide, a Lipopeptide from an Okeania sp. Marine Cyanobacterium. Reviewed International journal

    Kaori Ozaki, Arihiro Iwasaki, Dai Sezawa, Haruka Fujimura, Tomoyoshi Nozaki, Yumiko Saito-Nakano, Kiyotake Suenaga, Toshiaki Teruya

    Journal of natural products   82 ( 10 )   2907 - 2915   2019.10

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    DOI： 10.1021/acs.jnatprod.9b00749

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  • Cytotoxic Microcolin Lipopeptides from the Marine Cyanobacterium Moorea producens. Reviewed International journal

    Hao-Bing Yu, Evgenia Glukhov, Yueying Li, Arihiro Iwasaki, Lena Gerwick, Pieter C Dorrestein, Bing-Hua Jiao, William H Gerwick

    Journal of natural products   82 ( 9 )   2608 - 2619   2019.9

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    DOI： 10.1021/acs.jnatprod.9b00549

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  • Garcienone, a Novel Compound Involved in Allelopathic Activity of Garcinia Xanthochymus Hook. Reviewed International journal

    Md Mahfuzur Rob, Arihiro Iwasaki, Ryota Suzuki, Kiyotake Suenaga, Hisashi Kato-Noguchi

    Plants (Basel, Switzerland)   8 ( 9 )   2019.8

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    DOI： 10.3390/plants8090301

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  • Marine Natural Products: A Source of Novel Anticancer Drugs. Reviewed International journal

    Shaden A M Khalifa, Nizar Elias, Mohamed A Farag, Lei Chen, Aamer Saeed, Mohamed-Elamir F Hegazy, Moustafa S Moustafa, Aida Abd El-Wahed, Saleh M Al-Mousawi, Syed G Musharraf, Fang-Rong Chang, Arihiro Iwasaki, Kiyotake Suenaga, Muaaz Alajlani, Ulf Göransson, Hesham R El-Seedi

    Marine drugs   17 ( 9 )   2019.8

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    DOI： 10.3390/md17090491

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  • Total Synthesis, Stereochemical Revision, and Biological Assessment of Iriomoteolide-2a. Reviewed International journal

    Keita Sakamoto, Akihiro Hakamata, Arihiro Iwasaki, Kiyotake Suenaga, Masashi Tsuda, Haruhiko Fuwa

    Chemistry (Weinheim an der Bergstrasse, Germany)   25 ( 36 )   8528 - 8542   2019.6

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    DOI： 10.1002/chem.201900813

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  • Phytotoxic potential of Chrysopogon aciculatus (Retz.) Trin. (Poaceae)

    Md Shafiqul Islam, Farhana Zaman, Arihiro Iwasaki, Kiyotake Suenaga, Hisashi Kato-Noguchi

    Weed Biology and Management   19 ( 2 )   51 - 58   2019.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/wbm.12175

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  • Kyanamide, a new Ahp-containing depsipeptide from marine cyanobacterium Caldora penicillata

    Kaori Ozaki, Arihiro Iwasaki, Kiyotake Suenaga, Toshiaki Teruya

    TETRAHEDRON   75 ( 25 )   3382 - 3386   2019.6

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    DOI： 10.1016/j.tet.2019.04.046

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  • Allelopathic Potency and an Active Substance from Anredera cordifolia (Tenore) Steenis. Reviewed International journal

    Ichsan Nurul Bari, Hisashi Kato-Noguchi, Arihiro Iwasaki, Kiyotake Suenaga

    Plants (Basel, Switzerland)   8 ( 5 )   2019.5

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    DOI： 10.3390/plants8050134

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  • (+)-Isoamericanol A: A Plant Growth Inhibitor from Heliotropium indicum

    Sirinapa Chaipon, Sutjaritpan Boonmee, Arihiro Iwasaki, Kiyotake Suenaga, Hisashi Kato-Noguchi

    Natural Product Communications   14 ( 5 )   2019.5

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    DOI： 10.1177/1934578X19845788

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  • Phytotoxic activity of Chinese violet (Asystasia gangetica (L.) T. Anderson) and two phytotoxic substances

    Masahiko Suzuki, M. A. Chozin, Arihiro Iwasaki, Kiyotake Suenaga, Hisashi Kato-Noguchi

    Weed Biology and Management   19 ( 1 )   3 - 8   2019.3

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    DOI： 10.1111/wbm.12170

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  • Phytotoxic activity of kiwifruit leaves and isolation of a phytotoxic substance Reviewed

    Okada, S., Iwasaki, A., Kataoka, I., Suenaga, K., Kato-Noguchi, H.

    Scientia Horticulturae   250   243 - 248   2019.3

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    DOI： 10.1016/j.scienta.2019.02.029

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  • Minnamide A, a Linear Lipopeptide from the Marine Cyanobacterium Okeania hirsuta. Reviewed International journal

    Shimpei Sumimoto, Masayuki Kobayashi, Rio Sato, Seiichi Shinomiya, Arihiro Iwasaki, Shoichiro Suda, Toshiaki Teruya, Toshiyasu Inuzuka, Osamu Ohno, Kiyotake Suenaga

    Organic letters   21 ( 4 )   1187 - 1190   2019.2

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    DOI： 10.1021/acs.orglett.9b00135

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  • Evaluation of allelopathic competency of Lamium amplexicaule and identification of its allelopathic active substance

    Chisato Sakamoto, Masahiko Suzuki, Arihiro Iwasaki, Kiyotake Suenaga, Hisashi Kato-Noguchi

    Emirates Journal of Food and Agriculture   31 ( 2 )   76 - 80   2019.2

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    DOI： 10.9755/ejfa.2019.v31.i2.1907

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  • Evaluation of phytotoxic potential and identification of phytotoxic substances in Cassia alata Linn. leaves

    Krishna Rany Das, Arihiro Iwasaki, Kiyotake Suenaga, Hisashi Kato-Noguchi

    Acta Agriculturae Scandinavica Section B: Soil and Plant Science   69 ( 6 )   479 - 488   2019.1

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    DOI： 10.1080/09064710.2019.1603322

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  • Plant growth inhibitory activity of the extracts of acmella oleracea and its growth inhibitory substances

    Hisashi Kato-Noguchi, Prapaipit Suwitchayanon, Sutjaritpan Boonmee, Arihiro Iwasaki, Kiyotake Suenaga

    Natural Product Communications   14 ( 6 )   2019.1

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    DOI： 10.1177/1934578X19858805

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  • Phytotoxic activity of crop residues from Burdock and an active substance. Reviewed International journal

    Masahiko Suzuki, Arihiro Iwasaki, Kiyotake Suenaga, Hisashi Kato-Noguchi

    Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes   54 ( 11 )   877 - 882   2019

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    DOI： 10.1080/03601234.2019.1636600

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  • Allelopathic property and an allelopathic substance in Eleocharis atropurpurea (Retz.)

    Farhana Zaman, Arihiro Iwasaki, Kiyotake Suenaga, Hisashi Kato-Noguchi

    Theoretical and Experimental Plant Physiology   30 ( 4 )   347 - 355   2018.12

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    DOI： 10.1007/s40626-018-0130-5

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  • Hoshinoamides A and B, Acyclic Lipopeptides from the Marine Cyanobacterium Caldora penicillata. Reviewed International journal

    Arihiro Iwasaki, Takato Tadenuma, Shimpe Sumimoto, Ikuma Shiota, Teruhiko Matsubara, Yumiko Saito-Nakano, Tomoyoshi Nozaki, Toshinori Sato, Kiyotake Suenaga

    Journal of natural products   81 ( 11 )   2545 - 2552   2018.11

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    DOI： 10.1021/acs.jnatprod.8b00643

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  • Croissamide, a proline-rich cyclic peptide with an N-prenylated tryptophan from a marine cyanobacterium Symploca sp. Reviewed

    Iwasaki K, Iwasaki A, Sumimoto S, Sano T, Hitomi Y, Ohno O, Suenaga K

    Tetrahedron Letters   59 ( 42 )   3806 - 3809   2018.10

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    DOI： 10.1016/j.tetlet.2018.09.016

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  • Isolation and identification of a phytotoxic substance in kiwifruit leaves Reviewed

    Okada, S., Iwasaki, A., Kataoka, I., Suenaga, K., Kato-Noguchi, H.

    Acta Horticulturae   1218   207 - 212   2018.10

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    DOI： 10.17660/ActaHortic.2018.1218.28

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  • Isolation of Jahanene and Jahanane, and Total Synthesis of the Jahanyne Family. Reviewed International journal

    Arihiro Iwasaki, Haruka Fujimura, Shinichiro Okamoto, Takafumi Kudo, Shizuka Hoshina, Shimpei Sumimoto, Toshiaki Teruya, Kiyotake Suenaga

    The Journal of organic chemistry   83 ( 17 )   9592 - 9603   2018.9

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    DOI： 10.1021/acs.joc.8b00310

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  • Isolation and identification of a growth inhibitory substance from Heliotropium indicum L. Reviewed International journal

    Sirinapa Chaipon, Prapaipit Suwitchayanon, Arihiro Iwasaki, Kiyotake Suenaga, Hisashi Kato-Noguchi

    Acta biologica Hungarica   69 ( 3 )   259 - 269   2018.9

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    DOI： 10.1556/018.68.2018.3.3

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  • Izenamides A and B, Statine-Containing Depsipeptides, and an Analogue from a Marine Cyanobacterium. Reviewed International journal

    Yuki Kanamori, Arihiro Iwasaki, Shimpei Sumimoto, Teruhiko Matsubara, Toshinori Sato, Kiyotake Suenaga

    Journal of natural products   81 ( 7 )   1673 - 1681   2018.7

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    DOI： 10.1021/acs.jnatprod.8b00417

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  • Plant growth inhibitory activity and active substances with allelopathic potential of cogongrass (Imperata cylindrica) rhizome Reviewed

    Suzuki Masahiko, Tominaga Tohru, Ohno Osamu, Iwasaki Arihiro, Suenaga Kiyotake, Kato-Noguchi Hisashi

    Weed Biology and Management   8 ( 2 )   92 - 98   2018.6

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    DOI： 10.1111/wbm.12144

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  • Evaluation of phytotoxic activity of leaf and stem extracts and identification of a phytotoxic substance from Caesalpinia mimosoides Lamk. Reviewed

    Boonmee Sutjaritpan, Iwasaki Arihiro, Suenaga Kiyotake, Kato-Noguchi Hisashi

    Theoretical and Experimental Plant Physiology   30 ( 2 )   129 - 139   2018.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s40626-018-0108-3

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  • Ypaoamides B and C, Linear Lipopeptides from an Okeania sp. Marine Cyanobacterium. Reviewed International journal

    Kosuke Sueyoshi, Miki Yamada, Aki Yamano, Kaori Ozaki, Shimpei Sumimoto, Arihiro Iwasaki, Kiyotake Suenaga, Toshiaki Teruya

    Journal of natural products   81 ( 4 )   1103 - 1107   2018.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1021/acs.jnatprod.8b00088

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  • Total synthesis of janadolide Reviewed

    Ojima Daisuke, Mine Hitomi, Iwasaki Arihiro, Suenaga Kiyotake

    Tetrahedron Letters   59 ( 14 )   1360 - 1362   2018.4

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    DOI： 10.1016/j.tetlet.2018.02.034

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  • Caldorin, a new polyketide from the marine cyanobacterium Caldora penicillata Reviewed

    Shiota Ikuma, Iwasaki Arihiro, Sumimoto Shimpei, Tomoda Hiroshi, Suenaga Kiyotake

    Tetrahedron Letters   59 ( 13 )   1261 - 1263   2018.3

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    DOI： 10.1016/j.tetlet.2018.02.046

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  • Design, synthesis and anti-malarial activities of synthetic analogs of biselyngbyolide B, a Ca2+ pump inhibitor from marine cyanobacteria. Reviewed International journal

    Eisuke Sato, Maho Morita, Haruo Ogawa, Masato Iwatsuki, Rei Hokari, Aki Ishiyama, Satoshi Ōmura, Arihiro Iwasaki, Kiyotake Suenaga

    Bioorganic & medicinal chemistry letters   28 ( 3 )   298 - 301   2018.2

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    DOI： 10.1016/j.bmcl.2017.12.050

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  • Identification of 6,7-dimethoxychromone as a potent allelochemical from jatropha podagrica

    Sutjaritpan Boonmee, Arihiro Iwasaki, Kiyotake Suenaga, Hisashi Kato-Noguchi

    Natural Product Communications   13 ( 11 )   1515 - 1518   2018.1

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  • Evaluation of phytotoxic potential and identification of phytotoxic compounds in Rumex maritimus

    Islam, M.S., Iwasaki, A., Suenaga, K., Kato-Noguchi, H.

    Plant Biosystems   152 ( 4 )   2018

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    DOI： 10.1080/11263504.2017.1338630

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  • Total Synthesis of Kanamienamide and Clarification of Biological Activity. Reviewed International journal

    Daisuke Ojima, Arihiro Iwasaki, Kiyotake Suenaga

    The Journal of organic chemistry   82 ( 23 )   12503 - 12510   2017.12

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    DOI： 10.1021/acs.joc.7b02288

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  • 2-Methoxystypandrone, a potent phytotoxic substance in Rumex maritimus L Reviewed

    Islam Md Shafiqul, Iwasaki Arihiro, Suenaga Kiyotake, Kato-Noguchi Hisashi

    Theoretical and Experimental Plant Physiology   29 ( 4 )   195 - 202   2017.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s40626-017-0095-9

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  • Three New Malyngamides from the Marine Cyanobacterium Moorea producens. Reviewed International journal

    Kosuke Sueyoshi, Aki Yamano, Kaori Ozaki, Shimpei Sumimoto, Arihiro Iwasaki, Kiyotake Suenaga, Toshiaki Teruya

    Marine drugs   15 ( 12 )   2017.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.3390/md15120367

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  • Two allelopathic substances from Paspalum commersonii Lam. Reviewed

    Zaman Farhana, Iwasaki Arihiro, Suenaga Kiyotake, Kato-Noguchi Hisashi

    Acta Agriculturae Scandinavica Section B: Soil and Plant Science   68 ( 4 )   342 - 348   2017.11

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    DOI： 10.1080/09064710.2017.1401114

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  • Kohamamides A, B, and C, Cyclic Depsipeptides from an Okeania sp. Marine Cyanobacterium. Reviewed International journal

    Arihiro Iwasaki, Ikuma Shiota, Shimpei Sumimoto, Teruhiko Matsubara, Toshinori Sato, Kiyotake Suenaga

    Journal of natural products   80 ( 6 )   1948 - 1952   2017.6

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    DOI： 10.1021/acs.jnatprod.7b00256

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  • Phytotoxic property of the invasive plant Tithonia diversifolia and a phytotoxic substance. Reviewed International journal

    Masahiko Suzuki, Arihiro Iwasaki, Kiyotake Suenaga, Hisashi Kato-Noguchi

    Acta biologica Hungarica   68 ( 2 )   187 - 195   2017.6

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    DOI： 10.1556/018.68.2017.2.6

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  • Biseokeaniamides A, B, and C, Sterol O-Acyltransferase Inhibitors from an Okeania sp. Marine Cyanobacterium. Reviewed International journal

    Arihiro Iwasaki, Takato Tadenuma, Shimpei Sumimoto, Taichi Ohshiro, Kaori Ozaki, Keisuke Kobayashi, Toshiaki Teruya, Hiroshi Tomoda, Kiyotake Suenaga

    Journal of natural products   80 ( 4 )   1161 - 1166   2017.4

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    DOI： 10.1021/acs.jnatprod.7b00137

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  • Odobromoamide, a Terminal Alkynyl Bromide-Containing Cyclodepsipeptide from the Marine Cyanobacterium Okeania sp. Reviewed

    Kosuke Sueyoshi, Takafumi Kudo, Aki Yamano, Shimpei Sumimoto, Arihiro Iwasaki, Kiyotake Suenaga, Toshiaki Teruya

    BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN   90 ( 4 )   436 - 440   2017.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1246/bcsj.20160417

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  • Isolation and Total Synthesis of Hoshinolactam, an Antitrypanosomal Lactam from a Marine Cyanobacterium. Reviewed International journal

    Hidetoshi Ogawa, Arihiro Iwasaki, Shimpei Sumimoto, Masato Iwatsuki, Aki Ishiyama, Rei Hokari, Kazuhiko Otoguro, Satoshi O Mura, Kiyotake Suenaga

    Organic letters   19 ( 4 )   890 - 893   2017.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1021/acs.orglett.7b00047

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  • Isolation and identification of two potential phytotoxic substances from the aquatic fern Marsilea crenata

    Md Shafiqul Islam, Arihiro Iwasaki, Kiyotake Suenaga, Hisashi Kato-Noguchi

    JOURNAL OF PLANT BIOLOGY   60 ( 1 )   75 - 81   2017.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s12374-016-0408-6

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  • Myrislignan, a growth inhibitor from the roots of citronella grass

    Prapaipit Suwitchayanon, Prapaipit Suwitchayanon, Kiyotake Suenaga, Arihiro Iwasaki, Hisashi Kato-Noguchi

    Natural Product Communications   12 ( 7 )   1077 - 1078   2017.1

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  • Allelopathic potential and an allelopathic substance in mango leaves

    Masahiko Suzuki, Md Sirajul Islam Khan, Arihiro Iwasaki, Kiyotake Suenaga, Hisashi Kato-Noguchi

    ACTA AGRICULTURAE SCANDINAVICA SECTION B-SOIL AND PLANT SCIENCE   67 ( 1 )   37 - 42   2017

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    DOI： 10.1080/09064710.2016.1215517

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  • Total synthesis and stereochemical determination of yoshinone A. Reviewed International journal

    Seiichi Shinomiya, Arihiro Iwasaki, Osamu Ohno, Kiyotake Suenaga

    Phytochemistry   132   109 - 114   2016.12

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    DOI： 10.1016/j.phytochem.2016.10.005

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  • Total Synthesis of Miuraenamides A and D. Reviewed International journal

    Daisuke Ojima, Ayano Yasui, Koh Tohyama, Keita Tokuzumi, Eisuke Toriihara, Kayoko Ito, Arihiro Iwasaki, Tomohiko Tomura, Makoto Ojika, Kiyotake Suenaga

    The Journal of organic chemistry   81 ( 20 )   9886 - 9894   2016.10

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    DOI： 10.1021/acs.joc.6b02061

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  • Kanamienamide, an Enamide with an Enol Ether from the Marine Cyanobacterium Moorea bouillonii. Reviewed International journal

    Shimpei Sumimoto, Arihiro Iwasaki, Osamu Ohno, Kosuke Sueyoshi, Toshiaki Teruya, Kiyotake Suenaga

    Organic letters   18 ( 19 )   4884 - 4887   2016.10

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    DOI： 10.1021/acs.orglett.6b02364

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  • Urumamide, a novel chymotrypsin inhibitor with a beta-amino acid from a marine cyanobacterium Okeania sp.

    Yuki Kanamori, Arihiro Iwasaki, Shinpei Sumimoto, Kiyotake Suenaga

    TETRAHEDRON LETTERS   57 ( 37 )   4213 - 4216   2016.9

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    DOI： 10.1016/j.tetlet.2016.08.012

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  • Janadolide, a Cyclic Polyketide-Peptide Hybrid Possessing a tert-Butyl Group from an Okeania sp. Marine Cyanobacterium. Reviewed International journal

    Hidetoshi Ogawa, Arihiro Iwasaki, Shinpei Sumimoto, Yuki Kanamori, Osamu Ohno, Masato Iwatsuki, Aki Ishiyama, Rei Hokari, Kazuhiko Otoguro, Satoshi O̅mura, Kiyotake Suenaga

    Journal of natural products   79 ( 7 )   1862 - 6   2016.7

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    DOI： 10.1021/acs.jnatprod.6b00171

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  • Total synthesis and absolute configuration of koshikalide

    Kazuki Kunifuda, Arihiro Iwasaki, Masashi Nagamoto, Kiyotake Suenaga

    TETRAHEDRON LETTERS   57 ( 29 )   3121 - 3123   2016.7

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    DOI： 10.1016/j.tetlet.2016.06.002

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  • Anti-obesity activities of the yoshinone A and the related marine γ-pyrone compounds. Reviewed

    Tomoyuki Koyama, Yoshinori Kawazoe, Arihiro Iwasaki, Osamu Ohno, Kiyotake Suenaga, Daisuke Uemura

    The Journal of antibiotics   69 ( 4 )   348 - 51   2016.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/ja.2016.19

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  • Isolation and Structure of Kurahyne B and Total Synthesis of the Kurahynes. Reviewed International journal

    Shinichiro Okamoto, Arihiro Iwasaki, Osamu Ohno, Kiyotake Suenaga

    Journal of natural products   78 ( 11 )   2719 - 25   2015.11

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    DOI： 10.1021/acs.jnatprod.5b00662

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  • Identification of a molecular target of kurahyne, an apoptosis-inducing lipopeptide from marine cyanobacterial assemblages. Reviewed International journal

    Arihiro Iwasaki, Osamu Ohno, Shun Katsuyama, Maho Morita, Yukiko Sasazawa, Shingo Dan, Siro Simizu, Takao Yamori, Kiyotake Suenaga

    Bioorganic & medicinal chemistry letters   25 ( 22 )   5295 - 8   2015.11

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    DOI： 10.1016/j.bmcl.2015.09.044

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  • Total synthesis and stereochemical reassignment of maedamide

    Ayano Takayanagi, Arihiro Iwasaki, Kiyotake Suenaga

    TETRAHEDRON LETTERS   56 ( 34 )   4947 - 4949   2015.8

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    DOI： 10.1016/j.tetlet.2015.06.090

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  • Mebamamides A and B, Cyclic Lipopeptides Isolated from the Green Alga Derbesia marina. Reviewed International journal

    Arihiro Iwasaki, Osamu Ohno, Shinpei Sumimoto, Teruhiko Matsubara, Satoshi Shimada, Toshinori Sato, Kiyotake Suenaga

    Journal of natural products   78 ( 4 )   901 - 8   2015.4

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1021/acs.jnatprod.5b00168

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  • Jahanyne, an apoptosis-inducing lipopeptide from the marine cyanobacterium Lyngbya sp. Reviewed International journal

    Arihiro Iwasaki, Osamu Ohno, Shinpei Sumimoto, Hidetoshi Ogawa, Kim Anh Nguyen, Kiyotake Suenaga

    Organic letters   17 ( 3 )   652 - 5   2015.2

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    DOI： 10.1021/ol5036722

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  • An inhibitor of the adipogenic differentiation of 3T3-L1 cells, yoshinone A, and its analogs, isolated from the marine cyanobacterium Leptolyngbya sp.

    Toshiyasu Inuzuka, Keita Yamamoto, Arihiro Iwasaki, Osamu Ohno, Kiyotake Suenaga, Yoshinori Kawazoe, Daisuke Uemura

    TETRAHEDRON LETTERS   55 ( 49 )   6711 - 6714   2014.12

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    DOI： 10.1016/j.tetlet.2014.10.032

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  • Maedamide, a novel chymotrypsin inhibitor from a marine cyanobacterial assemblage of Lyngbya sp.

    Arihiro Iwasaki, Osamu Ohno, Shinpei Sumimoto, Shoichiro Suda, Kiyotake Suenaga

    TETRAHEDRON LETTERS   55 ( 30 )   4126 - 4128   2014.7

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.tetlet.2014.05.099

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  • Kurahamide, a Cyclic Depsipeptide Analog of Dolastatin 13 from a Marine Cyanobacterial Assemblage of Lyngbya sp.

    Arihiro Iwasaki, Shinpei Sumimoto, Osamu Ohno, Shoichiro Suda, Kiyotake Suenaga

    BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN   87 ( 5 )   609 - 613   2014.5

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1246/bcsj.20140008

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  • Kurahyne, an acetylene-containing lipopeptide from a marine cyanobacterial assemblage of Lyngbya sp.

    Arihiro Iwasaki, Osamu Ohno, Shinpei Sumimoto, Shoichiro Suda, Kiyotake Suenaga

    RSC ADVANCES   4 ( 25 )   12840 - 12843   2014

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    DOI： 10.1039/c4ra00132j

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  • Isolation and structure of koshikalide, a 14-membered macrolide from the marine cyanobacterium Lyngbya sp.

    Arihiro Iwasaki, Toshiaki Teruya, Kiyotake Suenaga

    TETRAHEDRON LETTERS   51 ( 6 )   959 - 960   2010.2

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.tetlet.2009.12.041

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  • 20-N-methylpurpuramine E: New bromotyrosine-derived metabolite from Okinawan marine sponge Pseudoceratina purpurea

    Toshiaki Teruya, Arihiro Iwasaki, Kiyotake Suenaga

    BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN   81 ( 8 )   1026 - 1027   2008.8

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    DOI： 10.1246/bcsj.81.1026

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Books

  • New tide of natural product chemistry

    Ishikawa, Hayato, 高山, 廣光

    Springer  2023  （ ISBN:9789819917136 ）

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  • Marine Natural Products, Topics in Heterocyclic Chemistry Vol. 58

    Kiyotake Suenaga, Arihiro Iwasaki, Reda A. Abdelhamid, Nicole E. Avalon, Bill J. Baker, Erick M. Carreira, Sarah Dietrick, Darren J. Dixon, Ahmed H, H. El-Desoky, Masaru Enomoto, James R. Frost, Haruhiko Fuwa, Kristin Herrera, Yasuhiro Igarashi, Jun Ishihara, Hayate Ishizuka, Pavol Jakubec, Carlos Jiménez, Hiromasa Kiyota, Sofia Kokkaliari, Hiroyuki Konno, Masaki Kuse, Shigefumi Kuwahara, Steven V. Ley, Kazuo Nagasawa, Kentaro Okano, Ryuichi Sakai, Philipp Sondermann, Tomoya Sugai, Sachiko Tsukamoto, Robert A. Uria, Toshiyuki Wakimoto, Joshua Welsch, Bingjie Yang, Ryan M. Young（Bioactive Substances from Marine Cyanobacteria）

    Springer  2021  （ ISBN:9789811646362 ）

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    Total pages：viii, 517 p.   Language：English  

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Presentations

  • 粟国島産未記載種海洋シアノバクテリア由来 Terukufazoline 類の単離，構造決定，生物活性および全合成

    田口 黎武, 海老原 玲, 恒松 雄太, Ghulam Jeelani, 野崎 智義, 末永 聖武, 岩崎 有紘

    日本農芸化学会 2024年度大会 

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  • 波照間島産海洋シアノバクテリア由来新規鎖状ペプチドの単離と構造決定

    入江 健介, Ghulam Jeelani, 野崎 智義, 岩崎 有紘

    第14回 CSJ化学フェスタ2024  2025.10 

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  • 渡名喜島産海洋シアノバクテリア由来 新規リポペプチド化合物の単離及び構造決定

    渡邉 夏海, Ghulam Jeelani, 野崎 智義, 岩崎 有紘

    第14回 CSJ化学フェスタ2024  2025.10 

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  • Bipemicilisorinの全合成と絶対立体配置の決定

    福田瑛吾, 藤原維吹, 丸野翔輝, 本村海輝, 遠藤聖也, 岩崎有紘, 福田達也, 中山淳, 品田哲郎

    第66回天然有機化合物討論会  2025.9 

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  • 抗トリパノソーマリポペプチドukabamideの単離、構造決定、全合成、および生物活性

    萩原大尋, 岩崎有紘, 田口黎武, Ghulam Jeelani, 野崎智義, 栗澤尚瑛, 末永聖武

    第66回天然有機化合物討論会  2025.9 

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  • 伊計島産海洋シアノバクテリア由来、新規シクロプロパン含有ポリケチド ikeiamide 類の単離及び構造決定

    田島 旦斐, 岩﨑 有紘, 山中 遼, 上田 貴裕, 大東 鷹翔

    日本化学会 第105春季年会  2025.3 

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  • 石垣島産海洋シアノバクテリア由来新規 PKS-NRPS ハイブリッド化合物の単離および構造決定

    藤木 雄人, 岩崎 有紘

    日本化学会 第105春季年会  2025.3 

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  • 沖縄県産海洋シアノバクテリア由来 polycavernoside 新規類縁体の単離と構造決定

    齊間 広人, 岩崎 有紘

    日本化学会 第105春季年会  2025.3 

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  • 鳩間島産海洋シアノバクテリア由来新規ジテルペン化合物の単離及び構造決定

    原 駿太, 岩﨑 有紘

    日本化学会 第105春季年会  2025.3 

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  • 竹富島産海洋シアノバクテリア由来新規スタチン含有ペプチドの単離及び構造

    山路 悠馬, 岩崎 有紘

    日本化学会 第105春季年会  2025.3 

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  • 渡名喜島産海洋シアノバクテリア由来新規リポペプチドの単離および構造決定

    渡邉 夏海, 岩崎 有紘

    日本化学会 第105春季年会  2025.3 

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  • 海洋に生息するシアノバクテリア由来のリポペプチドの生合成研究

    工藤史貴, 楠部瑞樹, 竹間琢自, 澄本慎平, 岩崎有紘, 末永聖武, 宮永顕正, 江口正

    第66回天然有機化合物討論会  2024.9 

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  • フィールドワークからはじめる海洋シアノバクテリアの天然物化学 Invited

    岩崎有紘

    第57回天然物化学談話会  2024.7 

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    Event date： 2024.7 　 　

    Presentation type：Oral presentation (invited, special)  

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  • 粟国島産未記載種海洋シアノバクテリア由来 Terukufazoline 類の単離，構造決定，生物活性および全合成

    田口 黎武, 海老原 玲, 恒松 雄太, Jeelani Ghulam, 野崎 智義, 末永 聖武, 岩崎 有紘

    日本薬学会 第144年会  2024.3 

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  • 伊江島産海洋シアノバクテリア由来の強力なカルシウムポンプ阻害剤イエゾシドの構造決定、全合成および生物活性

    栗澤 尚瑛, 岩﨑 有紘, 寺沼 和哉, 豊島 近, 橋本 勝, 旦 慎悟, 末永 聖武

    日本薬学会 第144年会  2024.3 

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  • 海洋シアノバクテリア由来新規鎖状ペプチドhedoamideの合成研究

    名倉 旭哉, 栗澤 尚瑛, 岩崎 有紘, 末永 聖武

    日本化学会 第104春季年会  2024.3 

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  • 沖縄県産海洋シアノバクテリア由来新規リポペプチukabamideの単離、構造決定、全合成および生物活性

    萩原 大尋, 田口 黎武, 岩﨑 有紘, Ghulam Jeelani, 野崎 智義, 栗澤 尚瑛, 末永 聖武

    日本化学会 第104春季年会  2024.3 

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  • 波照間島産海洋シアノバクテリア由来, 新規ペプチドの単離と構造決定

    入江 健介, 岩崎 有紘

    日本化学会 第104春季年会  2024.3 

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  • 海洋シアノバクテリア Okeania sp. 由来新規ペプチド化合物の単離及び構造決定

    渡邉夏海, 岩崎有紘

    日本化学会 第104春季年会  2024.3 

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  • 波照間島産海洋シアノバクテリア由来、新規末端アルキン含有ポリケチド化合物の単離と構造決定

    齊間 広人, 闐闐 孝介, 袖岡 幹子, 岩崎 有紘

    日本化学会第104春季年会  2024.3 

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  • 粟国島産未記載種海洋シアノバクテリア由来 Terukufazoline 類の単離，構造決定，⽣物活性および合成研究

    田口 黎武, 海老原 玲, 恒松 雄太, Jeelani Ghulam, 野崎 智義, 末永 聖武, 岩崎 有紘

    第65回天然有機化合物討論会  2023.9 

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  • 粟国島産未記載種海洋シアノバクテリア由来 Terukufazoline 類の単離，構造決定，⽣物活性および合成研究

    田口 黎武, 海老原 玲, 恒松 雄太, Jeelani Ghulam, 野崎 智義, 末永 聖武, 岩崎 有紘

    第69回毒素シンポジウム  2023.9 

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  • 海洋シアノバクテリア由来新規鎖状ペプチド hedoamide の構造と生物活性

    栗澤 尚瑛, 岩﨑 有紘, Ghulam Jeelani, Yulia Rahmawati, 野崎 智義, 末永 聖武

    日本化学会 第103春季年会  2023.3 

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  • 海洋シアノバクテリア由来新規天然物の発見とその価値の探索 Invited

    岩崎有紘

    日本化学会 第103春季年会 若い世代の特別講演会  2023.3 

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  • 海洋産シアノバクテリア由来新規Madangolide類縁体の単離と構造決定

    萩原 大尋, 末永 聖武, 岩崎 有紘

    日本化学会 第103春季年会  2023.3 

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  • 海洋シアノバクテリア由来の新規配糖体マクロリドakunolide類の単離及び構造決定

    梅田 海里, 岩崎 有紘, 末永 聖武

    日本化学会 第103春季年会  2023.3 

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  • Biselyngbyaside 人工類縁体の合成研究

    先山 佳寿, 岩崎 有紘, 末永 聖武

    日本化学会 第103春季年会  2023.3 

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  • 微量ポリケチドberu'amideの単離，構造決定，全合成および生物活性

    田口 黎武, 岩崎 有紘, 海老原 玲, Ghulam Jeelani, 野崎 智義, 末永 聖武

    第 12 回 CSJ 化学フェスタ 2022  2022.10 

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  • 微量ポリケチドberu'amideの単離，構造決定，全合成および生物活性

    田口黎武, 岩崎有紘, 海老原玲, Ghulam Jeelani, 野崎智義, 末永聖武

    第64回天然有機化合物討論会  2022.9 

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  • 沖縄県産海洋シアノバクテリア由来新規多ハロゲン化アリールエーテル類の単離，構造決定，生物 活性および全合成

    海老原玲, 岩崎有紘, 三浦洋平, Ghulam Jeelani, 野崎智義, 末永聖武

    第68回トキシンシンポジウム  2022.9 

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  • 初心者のための海洋シアノバクテリア採集入門

    岩﨑有紘

    第55回天然物化学談話会  2022.6 

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  • リングビアペプチンB推定生合成遺伝子クラスター中の二鉄含有酸化酵素の機能解析

    楠部瑞樹, 竹間琢自, 岩﨑有紘, 末永聖武, 宮永顕正, 工藤史貴, 江口正

    日本化学会第102春季年会  2022.3 

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  • 海洋シアノバクテリア由来新規ポリケチドTomurulineの全合成

    宮本裕太, 藤村遥, 岩崎有紘, 末永聖武

    日本化学会第102春季年会  2022.3 

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  • 海洋シアノバクテリア由来ペプチド・ポリケチドハイブリッド配糖体iezosideの合成研究

    寺沼和哉, 栗澤尚瑛, 岩﨑有紘, 末永聖武

    日本化学会第102春季年会  2022.3 

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  • 海洋シアノバクテリア由来新規テルペノイドの単離，構造決定

    海老原玲, 岩﨑有紘, 末永聖武

    日本化学会第102春季年会  2022.3 

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  • 沖縄県産海洋シアノバクテリア由来の新規不飽和δ-ラクトン含有ポリケチド類の単離と構造決定

    高橋寛樹, 岩崎有紘, 金井航, 末永聖武

    日本化学会第102春季年会  2022.3 

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  • 海洋産リポペプチド Minnamide A 脂肪酸部分の合成研究

    岸本勇志, 小林正幸, 岩崎有紘, 末永聖武

    日本化学会第102春季年会  2022.3 

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  • 鹿児島県産海洋シアノバクテリア由来新規ポリケチド化合物Beru’amideの単離と構造決定、及び全合成研究

    田口黎武, 岩崎有紘, 末永聖武

    日本化学会第102春季年会  2022.3 

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  • Natural Products from Marine Cyanobacteria: Fascinating Structures and Biological Activities Invited

    Arihiro Iwasaki

    German-Japanese Meeting 2022 Green Aquatic Biology: Ecology meets Synthetic Biology  2022.3 

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  • 海洋シアノバクテリア Leptolyngbya sp. 由来新規環状ペプチド類の単離、構造決定、生物活性

    高橋寛樹, 岩崎有紘, 栗澤尚瑛, 鈴木良太, JEELANI Ghulam, 野崎智義, 末永聖武

    第11回CSJ化学フェスタ  2021.10 

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  • 沖縄県産海洋シアノバクテリア由来新規多ハロゲン化アリールエーテル類の単離，構造決定，全合成

    海老原玲, 岩崎有紘, 末永聖武, 三浦洋平, GHULAM Jeelani, 野崎智義

    第11回CSJ化学フェスタ  2021.10 

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  • 新規ペプチド-ポリケチドハイブリッド配糖体 iezoside の構造と生物活性

    栗澤尚瑛, 岩﨑有紘, 寺沼和哉, 旦慎吾, 豊島近, 橋本勝, 末永 聖武

    第63回天然有機化合物討論会  2021.9 

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  • 海洋シアノバクテリア由来新規ペプチド-ポリケチドハイブリッド化合物 iezoside の 構造と生物活性

    栗澤尚瑛, 岩﨑有紘, 末永聖武

    第67回トキシンシンポジウム  2021.9 

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  • 新規 SERCA 阻害剤 iezoside の構造と生物活性

    栗澤尚瑛, 岩﨑有紘, 寺沼和哉, 旦慎吾, 豊島近, 末永聖武

    日本ケミカルバイオロジー学会第15回年会  2021.6 

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  • 海洋シアノバクテリア Leptolyngbya sp. 由来新規環状ペプチド類の単離と構造決定

    高橋 寛樹, 岩﨑有紘, 鈴木良太, 末永聖武

    日本化学会第101春季年会  2021.3 

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  • 沖縄県産海洋シアノバクテリア由来の鎖状ペプチド komesuamide の単離、構造決定と生物活性

    神野敦秀, 尾崎香織, 夏目矩行, 岩崎有紘, 末永聖武, 照屋 俊明

    日本化学会第101春季年会  2021.3 

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  • 海洋シアノバクテリア由来新規ペプチド-ポリケチドハイブリッド化合物 iezoside の構造と生物活性

    栗澤尚瑛, 岩﨑有紘, 末永聖武

    日本化学会第101春季年会  2021.3 

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  • 海洋産リポペプチドMinnamide Aペプチド部の合成研究

    佐藤理央, 岸本勇志, 岩﨑有紘, 末永 聖武

    日本化学会第101春季年会  2021.3 

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  • 海洋シアノバクテリア由来新規鎖状デプシペプチドkinenzolineの単離及び全合成

    大友啓介, 栗澤尚瑛, 岩﨑有紘, 末永 聖武

    日本化学会第101春季年会  2021.3 

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  • 海洋産抗トリパノソーマ鎖状ペプチドIheyanide Aの全合成

    寺沼和哉, 栗澤尚瑛, 岩﨑有紘, 末永 聖武

    日本化学会第101春季年会  2021.3 

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  • 新規チアゾール含有ポリケチドtomurulineの合成研究

    宮本裕太, 岩崎有紘, 末永 聖武

    日本化学会第101春季年会  2021.3 

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  • 海洋産リポペプチド Minnamide A 脂肪酸部分の合成研究

    岸本 勇志, 佐藤理央, 岩崎有紘, 末永 聖武

    日本化学会第101春季年会  2021.3 

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  • Biselyngbyaside 人工類縁体の合成研究

    廣瀬太朗, 佐藤英祐, 岩﨑有紘, 末永 聖武

    日本化学会第101春季年会  2021.3 

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  • 沖縄県産海洋シアノバクテリア由来新規多ハロゲン化アリールエーテル類の単離と構造決定，及び全合成研究

    海老原玲, 岩﨑有紘, 末永聖武

    日本化学会第101春季年会  2021.3 

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  • 海洋シアノバクテリア由来の新規鎖状ペプチドiheyamide類の構造と生物活性

    栗澤尚瑛, 岩﨑有紘, Ghulam Jeelani, 野崎智義, 末永聖武

    第62回天然有機化合物討論会  ( オンライン開催 )   2020.9 

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  • 海洋シアノバクテリア由来の生物活性物質 Invited

    末永聖武, 岩﨑有紘, 森田真布, 佐藤英祐, 照屋俊明, 大野修

    農芸化学会2020年度大会、シンポジウム「シアノバクテリアと未来を描く」  ( 誌上開催 )   2020.3 

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  • 細胞老化に関わるLncRNA（LINC00942）の発現を制御する成分の探索

    礒田隆宏, 岩﨑有紘, 岡部伊織, 宍戸まゆみ, 斉藤優子, 末永聖武, 楊 一幸

    日本薬学会第140年会  ( 誌上開催 )   2020.3 

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  • Synthetic Studies on Ikoamide

    末永聖武, 駱永翰, 岩﨑有紘

    日本化学会第100春季年会  ( 誌上開催 )   2020.3 

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  • 海洋シアノバクテリア由来リポペプチド Jahanyne 類のアポトーシス誘導活性の作用機序解明研究

    保科静香, 岩﨑有紘, 工藤隆文, 田代 悦, 照屋俊明, 井本正哉, 末永聖武

    日本化学会第100春季年会  ( 誌上開催 )   2020.3 

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  • 直接的アルキン濃縮精製法を駆使した海洋シアノバクテリア由来新規リポペプチド類の単離と構造決定

    髙橋寛樹, 岩﨑有紘, 大金賢司, 中尾周平, 闐闐孝介, 袖岡幹子, 末永聖武

    日本化学会第100春季年会  ( 誌上開催 )   2020.3 

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  • リングビアぺプチンB推定生合成遺伝子クラスター中にコードされる酵素の機能解析

    竹間琢自, 澄本慎平, 岩﨑有紘, 末永聖武, 宮永顕正, 工藤史貴, 江口 正

    日本化学会第100春季年会  ( 誌上開催 )   2020.3 

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  • 海洋鎖状リポペプチド hoshinoamide C の全合成と絶対立体配置の決定

    大友啓介, 末永聖武, 岩﨑有紘

    日本化学会第100春季年会  ( 誌上開催 )   2020.3 

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  • 海洋シアノバクテリア由来新規鎖状ペプチド Iheyamide 類の単離と構造決定

    栗澤尚瑛, 岩﨑有紘, 末永聖武

    日本化学会第100春季年会  ( 誌上開催 )   2020.3 

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  • 沖縄産海洋シアノバクテリア由来新規鎖状ペプチドの単離、構造決定および糖取り込み活性の評価

    尾崎香織, 澄本慎平, 岩﨑有紘, 末永聖武, 照屋俊明

    日本化学会第100春季年会  ( 誌上開催 )   2020.3 

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  • 海洋産リポペプチドMinnamide A脂肪酸部分の合成研究1

    岸本勇志, 小林正幸, 佐藤理央, 岩﨑有紘, 末永聖武

    日本化学会第100春季年会  ( 誌上開催 )   2020.3 

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  • 海洋産リポペプチドMinnamide A脂肪酸部分の合成研究2

    小林正幸, 佐藤理央, 岸本勇志, 岩﨑有紘, 末永聖武

    日本化学会第100春季年会  ( 誌上開催 )   2020.3 

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  • 海洋産リポペプチドMinnamide Aペプチド部分の合成研究

    佐藤理央, 小林正幸, 岸本勇志, 岩﨑有紘, 末永聖武

    日本化学会第100春季年会  ( 誌上開催 )   2020.3 

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  • Discovery and Biological Activities of Novel Lipopeptides Isolated from Marine Cyanobacteria Invited

    Arihiro Iwasaki

    2019.12 

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  • 海洋性シアノバクテリア由来鎖状リポペプチド Jahanyne 類の構造，全合成および生物活性

    保科静香, 岩﨑有紘, 藤村 遥, 岡本慎一朗, 工藤隆文, 澄本慎平, NGUYEN Kim Anh, 小川英俊, 大野 修, 照屋俊明, 末永聖武

    第９回CSJ化学フェスタ  ( タワーホール船堀 )   2019.10  日本化学会

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  • Discovery, total synthesis and mode of action of kurahyne, a novel ER stress–inducer from a marine cyanobacterium Invited

    Arihiro Iwasaki

    One Belt, One Road’ Young Scientist Forum  2019.9 

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  • 強力な抗トリパノソーマ活性を示す海洋天然物hoshinolactam類の単離、構造決定、 全合成と生物活性

    岩崎有紘, 小川英俊, 澄本慎平, 鄭丞宰, 岩月正人, 石山亜紀, 穂刈玲, 乙黒一彦, 大村智, 中野由美子, 野崎智義, 末永聖武

    第61回天然有機化合物討論会  ( 広島国際会議場 )   2019.9 

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  • 医薬品候補物質の探索源としての海洋シアノバクテリア Invited

    岩﨑有紘

    2019年ラン藻ゲノム交流会  2019.6 

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  • 海洋天然物 jahanyne 類の全合成および結合タンパク質の同定

    保科静香, 岩﨑有紘, 藤村遥, 岡本慎一朗, 工藤隆文, 照屋俊明, 末永聖武

    日本ケミカルバイオロジー学会第14回年会  ( ウインクあいち（名古屋市） )   2019.6 

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  • 海洋シアノバクテリア由来鎖状リポペプチドMinnamide Aの単離、構造決定および生物活性

    澄本慎平, 小林正幸, 佐藤理央, 四宮誠一, 岩﨑有紘, 須田彰一郎, 照屋俊明, 犬塚俊康, 大野修, 末永聖武

    日本ケミカルバイオロジー学会第14回年会  ( ウインクあいち（名古屋市） )   2019.6 

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  • Discovery, total synthesis and mode of action of kurahyne, a novel ER stress–inducer from a marine cyanobacterium Invited

    Arihiro Iwasaki

    2019.5 

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  • 海洋リポペプチドJahanyne類の結合タンパク質の探索及び同定

    保科静香, 岩﨑有紘, 工藤隆文, 照屋俊明, 末永聖武

    日本化学会第99春季年会  ( 甲南大学岡本キャンパス )   2019.3  日本化学会

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  • チアゾール含有ポリケチドtomurulineの合成研究2

    藤村 遥, 工藤千尋, 大野 修, 岩﨑有紘, 末永聖武

    日本化学会第99春季年会  ( 甲南大学岡本キャンパス )   2019.3  日本化学会

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  • 海洋シアノバクテリア由来の新規ペプチド hoshinoamides C-E の単離と構造

    塩田育万, 岩﨑有紘, 澄本慎平, 末永聖武

    日本化学会第99春季年会  ( 甲南大学岡本キャンパス )   2019.3  日本化学会

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  • 沖縄県産海洋シアノバクテリア由来新規鎖状リポペプチドの単離と構造決定

    岩﨑慶太郎, 岩﨑有紘, 澄本慎平, 末永聖武

    日本化学会第99春季年会  ( 甲南大学岡本キャンパス )   2019.3  日本化学会

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  • 海洋産リポペプチドMinnamide AにおけるC-9位メチル基の合成的手法による絶対立体配置の決定

    小林正幸, 佐藤理央, 澄本慎平, 四宮誠一, 照屋俊明, 岩﨑有紘, 末永聖武

    日本化学会第99春季年会  ( 甲南大学岡本キャンパス )   2019.3  日本化学会

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  • Janadolideの標的たんぱく質同定のためのプローブ合成を志向した人工類縁体の合成研究

    大友啓介, 小島大輔, 小川英俊, 岩﨑有紘, 末永聖武

    日本化学会第99春季年会  ( 甲南大学岡本キャンパス )   2019.3  日本化学会

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  • 沖縄県産海洋シアノバクテリアにおける新規生理活性物質の探索

    尾崎香織, 瀬澤 大, 藤村 遥, 岩﨑有紘, 末永聖武, 照屋俊明

    日本化学会第99春季年会  ( 甲南大学岡本キャンパス )   2019.3  日本化学会

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  • Discovery, Total Synthesis and Mode of Action of Kurahyne, a Novel ER Stress–Inducer from a Marine Cyanobacterium Invited

    Arihiro Iwasaki

    Skaggs School of Pharmacy and Pharmaceutical Sciences Seminar Series, University of California San Diego  2019.1 

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  • Cytotoxicity Structure-activity Relationship and Synthesis of Biotin Probes of Marine Lipopeptide Jahanyne and Related Compounds. International conference

    Shizuka Hoshina, Arihiro Iwasaki, Takafumi Kudo, Toshiaki Teruya, Kiyotake Suenaga

    30th IUPAC Symposium on the Chemistry of Natural Products,  ( Athens, Greece )   2018.11 

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  • A marine lipopeptide, minnamide A: Synthetic studies for assignment of the C-9 methyl stereochemistry. International conference

    Masayuki Kobayashi, Shimpei Sumimoto, Seiichi Shinomiya, Toshiaki Teruya, Arihiro Iwasaki, Kiyotake Suenaga

    30th IUPAC Symposium on the Chemistry of Natural Products,  ( Athens, Greece )   2018.11 

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  • Isolation and structure determination of two new peptides from marine cyanobacteria. International conference

    Keitaro Iwasaki, Arihiro Iwasaki, Simpei Sumimoto, Kiyotake Suenaga

    30th IUPAC Symposium on the Chemistry of Natural Products,  ( Athens, Greece )   2018.11 

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  • Isolation and Structure Determination of Four New Compounds from Marine Cyanobacteria. International conference

    Ikuma Shiota, Shimpei Sumimoto, Arihiro Iwasaki, Kiyotake Suenaga

    30th IUPAC Symposium on the Chemistry of Natural Products,  ( Athens, Greece )   2018.11 

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  • Structure, Total Synthesis and Biological Activities of Marine Lipopeptide Jahanyne and its Analogs Invited

    Arihiro Iwasaki, Shinichiro Okamoto, Haruka Fujimura, Takafumi Kudo, Shizuka Hoshina, Shimpei Sumimoto, Toshiaki Teruya, Kiyotake Suenaga

    International Congress on Pure and Applied Chemistry Langkawi 2018  2018.11 

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  • 海洋性鎖状リポペプチド、Jahanyne類の構造と合成、生物活性

    岩﨑有紘, 岡本慎一朗, 藤村 遥, 工藤隆文, 保科静香, 澄本慎平, 中野由美子, 野崎智義, 照屋俊明, 末永聖武

    第60回天然有機化合物討論会  ( 久留米シティプラザ )   2018.9 

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  • Structure, Total Synthesis and Biological Activities of Marine Lipopeptide Jahanyne and its Analogs Invited

    Arihiro Iwasaki

    Inner Mongolia University  2018.6 

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  • 抗寄生虫活性を示す海洋天然物の作用機序解明を指向した合成研究

    岩﨑有紘, 小島大輔, 小川英俊, 保科静香, 鄭 丞宰, 岩月正人, 中野由美子, 石山亜紀, 穂刈 玲, 乙黒一彦, 大村智, 野崎智義, 末永聖武

    日本ケミカルバイオロジー学会第13回年会  ( 東京医科歯科大学 )   2018.6  日本ケミカルバイオロジー学会

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  • 海洋生物由来リポポリサッカライド（LPS）機能調節物質の探索

    人見 悠毅, 寺崎 拓郎, 岩﨑 有紘, 末永 聖武, 松野 研司, 大野 修

    新規素材探索研究会第17回セミナー  ( 新横浜フジビューホテル )   2018.6  新規素材探索研究会

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  • 沖縄県産海洋シアノバクテリア由来新規環状ペプチドcroissamideの単離と構造決定

    岩﨑 慶太郎, 岩﨑 有紘, 澄本 慎平, 末永 聖武

    新規素材探索研究会第17回セミナー  ( 新横浜フジビューホテル )   2018.6  新規素材探索研究会

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  • 抗寄生虫活性を示す新規海洋天然物の単離、構造決定、全合成と生物活性

    岩﨑 有紘, 小川 英俊, 鄭 丞宰, 澄本 慎平, 穂刈 玲, 石山 亜紀, 中野 由美子, 岩月 正人, 乙黒 一彦, 野崎 智義, 大村 智, 末永 聖武

    新規素材探索研究会第17回セミナー  ( 新横浜フジビューホテル )   2018.6  新規素材探索研究会

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  • 海洋性シアノバクテリア由来鎖状リポペプチドJahanyne類の構造、全合成および生物活性

    保科 静香, 岩﨑 有紘, 藤村 遥, 岡本 慎一朗, 工藤 隆文, 澄本 慎平, NGUYEN Kim Anh, 小川 英俊, 大野 修, 照屋 俊明, 末永 聖武

    新規素材探索研究会第17回セミナー  ( 新横浜フジビューホテル )   2018.6  新規素材探索研究会

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  • チアゾール含有ポリケチドtomurulineの合成研究

    藤村 遥, 工藤 千尋, 大野 修, 岩﨑 有紘, 末永 聖武

    新規素材探索研究会第17回セミナー  ( 新横浜フジビューホテル )   2018.6  新規素材探索研究会

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  • 海洋シアノバクテリア由来の新規ポリケチドcaldorinの単離と構造2

    塩田 育万, 岩﨑 有紘, 澄本 慎平, 関 怜子, 小林 啓介, 供田 洋, 末永 聖武

    新規素材探索研究会第17回セミナー  ( 新横浜フジビューホテル )   2018.6  新規素材探索研究会

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  • 海洋産リポペプチドMinnamideAの合成研究と立体化学の決定2

    小林 正幸, 澄本 慎平, 四宮 誠一, 照屋 俊明, 岩﨑 有紘, 末永 聖武

    新規素材探索研究会第17回セミナー  ( 新横浜フジビューホテル )   2018.6  新規素材探索研究会

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  • 海洋シアノバクテリア由来の新規天然物に関する生物有機化学的研究 Invited

    岩﨑有紘

    第6回慶應有機化学若手シンポジウム  2018.5 

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  • Structure and synthetic study of lipopeptides, isolated from marine cyanobacteria. Invited International conference

    Shimpei Sumimoto, Daisuke Ojima, Masayuki Kobayashi, Seiichi Shinomiya, Arihiro Iwasaki, Toshiaki Teruya, Kiyotake Suenaga

    2018 International Conferenece on Frontier Chemistry and Life Sciences  ( Kaohsiung Medical University, Kaohsiung )   2018.5 

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  • 海洋シアノバクテリア由来の新規ポリケチド caldorin の単離と構造

    SUENAGA Kiyotake

    日本化学会第98春季年会  ( 日本大学船橋キャンパス )   2018.3  日本化学会

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  • 海洋産リポペプチドMinnamide Aの合成研究と立体化学の決定

    SUENAGA Kiyotake

    日本化学会第98春季年会  ( 日本大学船橋キャンパス )   2018.3  日本化学会

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  • 新規チアゾール含有ポリケチドtomurulineの合成研究

    SUENAGA Kiyotake

    日本化学会第98春季年会  ( 日本大学船橋キャンパス )   2018.3  日本化学会

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  • 海洋リポペプチドJahanyne類の構造活性相関とビオチンプローブの合成

    SUENAGA Kiyotake

    日本化学会第98春季年会  ( 日本大学船橋キャンパス )   2018.3  日本化学会

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  • 海洋生物由来のリポポリサッカライド（LPS）の機能を阻害する化合物の探索

    SUENAGA Kiyotake

    日本化学会第98春季年会  ( 日本大学船橋キャンパス )   2018.3  日本化学会

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  • 沖縄県産海洋シアノバクテリア由来新規環状ペプチドの単離と構造決定

    SUENAGA Kiyotake

    日本化学会第98春季年会  ( 日本大学船橋キャンパス )   2018.3  日本化学会

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  • 石垣島産海洋シアノバクテリア由来、新規鎖状ペプチドホシノアミド類の単離と構造

    SUENAGA Kiyotake

    日本化学会第98春季年会  ( 日本大学船橋キャンパス )   2018.3  日本化学会

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  • 沖縄県産海洋生物における糖取り込み物質の探索

    SUENAGA Kiyotake

    日本化学会第98春季年会  ( 日本大学船橋キャンパス )   2018.3  日本化学会

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  • エナミド構造を有する11員環マクロラクトンKanamienamideの合成研究

    SUENAGA Kiyotake

    日本化学会第98春季年会  ( 日本大学船橋キャンパス )   2018.3  日本化学会

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  • 海洋生物由来のリポポリサッカライド（LPS）の機能を阻害する化合物の探索

    SUENAGA Kiyotake

    日本化学会第98春季年会  ( 日本大学船橋キャンパス )   2018.3  日本化学会

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  • Total Synthesis and Biological Evaluations of Biselyngbyasides

    SATO, Eisuke, SATO, Miho, TABANE, Yurika, NAKAJIMA, Naoya, OHKUBO, Akifumi, IWATSUKI, Masato, OGAWA, Haruo, TOYOSHIMA, Chikashi, MORITA, Maho, IWASAKI, Arihiro, SUENAGA, Kiyotake

    日本化学会第98春季年会  ( 日本大学船橋キャンパス )   2018.3  日本化学会

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  • 海洋シアノバクテリア由来新規リポペプチドminnamide類の構造および生物活性 Invited

    SUENAGA Kiyotake

    新規素材探索研究会第16回セミナー  ( 新横浜フジビューホテル )   2017.6  新規素材探索研究会

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  • 海洋生物由来栄養飢餓選択的細胞死誘導物質の探索 Invited

    SUENAGA Kiyotake

    新規素材探索研究会第16回セミナー  ( 新横浜フジビューホテル )   2017.6  新規素材探索研究会

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  • 海洋シアノバクテリア由来の新規環状デプシペプチド kohamamide 類の単離と構造 Invited

    SUENAGA Kiyotake

    新規素材探索研究会第16回セミナー  ( 新横浜フジビューホテル )   2017.6  新規素材探索研究会

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  • Jahanyne 類の合成研究 Invited

    SUENAGA Kiyotake

    新規素材探索研究会第16回セミナー  ( 新横浜フジビューホテル )   2017.6  新規素材探索研究会

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  • 海洋シアノバクテリア由来新規天然物の構造と生物活性

    岩崎有紘, 小川英俊, 蓼沼隆人, 澄本慎平, 末永聖武

    日本ケミカルバイオロジー学会第12回年会  ( 北海道大学 )   2017.6  日本ケミカルバイオロジー学会

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  • Discovery, total synthesis and mode of action of kurahyne, a novel ER stress–inducer from a marine cyanobacterium Invited

    Arihiro Iwasaki

    Inner Mongolia University  2017.5 

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  • 抗肥満リードYoshinone Aの合成研究

    SUENAGA Kiyotake

    日本化学会第97春季年会  ( 慶應義塾大学日吉キャンパス )   2017.3  日本化学会

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  • 新規チアゾール含有ポリケチドtomurulineの合成研究

    SUENAGA Kiyotake

    日本化学会第97春季年会  ( 慶應義塾大学日吉キャンパス )   2017.3  日本化学会

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  • kalkipyroneによる栄養飢餓選択的な細胞死誘導機構の解明

    SUENAGA Kiyotake

    日本化学会第97春季年会  ( 慶應義塾大学日吉キャンパス )   2017.3  日本化学会

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  • 沖縄県備瀬産海洋シアノバクテリア由来の新規類縁体Jahanyne B,Cの構造と生物活性

    SUENAGA Kiyotake

    日本化学会第97春季年会  ( 慶應義塾大学日吉キャンパス )   2017.3  日本化学会

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  • 末端アルキン含有リポペプチドjahanyneの合成研究

    SUENAGA Kiyotake

    日本化学会第97春季年会  ( 慶應義塾大学日吉キャンパス )   2017.3  日本化学会

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  • エナミド構造を有する環状デプシペプチドKanamienamideの合成研究

    SUENAGA Kiyotake

    日本化学会第97春季年会  ( 慶應義塾大学日吉キャンパス )   2017.3  日本化学会

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  • 海洋産リポペプチドMinnamide Aの合成研究

    SUENAGA Kiyotake

    日本化学会第97春季年会  ( 慶應義塾大学日吉キャンパス )   2017.3  日本化学会

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  • 海洋シアノバクテリア由来新規リポペプチド Minnamide 類の単離と構造決定

    SUENAGA Kiyotake

    日本化学会第97春季年会  ( 慶應義塾大学日吉キャンパス )   2017.3  日本化学会

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  • 海洋シアノバクテリア由来の新規環状デプシペプチドkohamamide類の単離と構造

    SUENAGA Kiyotake

    日本化学会第97春季年会  ( 慶應義塾大学日吉キャンパス )   2017.3  日本化学会

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  • 沖縄県産海洋生物由来筋管細胞糖取り込み活性物質の探索

    SUENAGA Kiyotake

    日本化学会第97春季年会  ( 慶應義塾大学日吉キャンパス )   2017.3  日本化学会

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  • 抗トリパノソーマ活性を有する海洋シアノバクテリア由来新規ポリケチド-ペプチドハイブリッド Hoshinolactamの全合成

    SUENAGA Kiyotake

    日本化学会第97春季年会  ( 慶應義塾大学日吉キャンパス )   2017.3  日本化学会

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  • 抗トリパノソーマ活性を有する海洋シアノバクテリア由来新規ポリケチド-ペプチドハイブリッド Hoshinolactamの単離と構造決定

    SUENAGA Kiyotake

    日本化学会第97春季年会  ( 慶應義塾大学日吉キャンパス )   2017.3  日本化学会

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  • 沖縄県産海洋シアノバクテリア由来、新規鎖状デプシペプチドの単離と構造決定

    SUENAGA Kiyotake

    日本化学会第97春季年会  ( 慶應義塾大学日吉キャンパス )   2017.3  日本化学会

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  • 沖縄県産海洋シアノバクテリア由来チアゾール含有ペプチドの単離と構造

    SUENAGA Kiyotake

    日本化学会第97春季年会  ( 慶應義塾大学日吉キャンパス )   2017.3  日本化学会

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  • 海洋シアノバクテリア由来のリポペプチドの構造

    SUENAGA Kiyotake

    第58回天然有機化合物討論会  ( 仙台 )   2016.9 

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  • 海洋シアノバクテリア由来、新規ペプチド性化合物の構造と生物活性 Invited

    岩﨑有紘

    理研シンポジウム 高磁場・高感度 NMR 利活用促進のための天然物関連シンポジウム 2016  2016.7 

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  • 海洋シアノバクテリア由来リポペプチドの単離と構造決定 Invited

    SUENAGA Kiyotake

    新規素材探索研究会第15回セミナー  ( 新横浜フジビューホテル )   2016.6  新規素材探索研究会

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  • 海洋シアノバクテリア由来リポペプチドの単離と構造決定 Invited

    SUENAGA Kiyotake

    新規素材探索研究会第15回セミナー  ( 新横浜フジビューホテル )   2016.6  新規素材探索研究会

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  • 環状リポペプチドJanadolideの合成研究 Invited

    SUENAGA Kiyotake

    新規素材探索研究会第15回セミナー  ( 新横浜フジビューホテル )   2016.6  新規素材探索研究会

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  • 海洋シアノバクテリア由来、新規環状ペプチド urumamideの単離と構造決定 Invited

    SUENAGA Kiyotake

    新規素材探索研究会第15回セミナー  ( 新横浜フジビューホテル )   2016.6  新規素材探索研究会

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  • 海洋シアノバクテリア集合体由来、新規環状ペプチド、クラハミドの構造と生物活性

    岩﨑有紘, 澄本慎平, 大野 修, 末永聖武

    日本化学会第96春季年会  ( 同志社大学京田辺キャンパス )   2016.3  日本化学会

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  • t-ブチル基を有する海洋シアノバクテリア由来新規環状リポペプチド Janadolide の絶対立体配置の決定

    小川英俊, 岩﨑有紘, 澄本慎平, 金森祐紀, 大野 修, 末永聖武

    日本化学会第96春季年会  ( 同志社大学京田辺キャンパス )   2016.3  日本化学会

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  • 沖縄県産海洋シアノバクテリア Okeania sp. 由来の新規鎖状ペプチドの単離と構造

    蓼沼隆人, 澄本慎平, 岩﨑有紘, 末永聖武

    日本化学会第96春季年会  ( 同志社大学京田辺キャンパス )   2016.3  日本化学会

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  • 沖縄県産海洋シアノバクテリア由来、新規環状ペプチドの単離と構造決定

    金森祐紀, 澄本慎平, 岩﨑有紘, 末永聖武

    日本化学会第96春季年会  ( 同志社大学京田辺キャンパス )   2016.3  日本化学会

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  • 海洋シアノバクテリア由来新規エナミドの単離と構造

    澄本慎平, 岩﨑有紘, 大野 修, 工藤史貴, 末永聖武

    日本化学会第96春季年会  ( 同志社大学京田辺キャンパス )   2016.3  日本化学会

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  • 海洋生物由来ポリケチド化合物による栄養飢餓選択的な細胞死誘導機構の解析

    大野 修, 伊藤明美, 岩﨑有紘, 末永聖武, 松野研司

    日本化学会第96春季年会  ( 同志社大学京田辺キャンパス )   2016.3  日本化学会

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  • 末端アルキン含有リポペプチドJahanyne の合成研究

    岡本慎一朗, 岩﨑有紘, 大野 修, 末永聖武

    日本化学会第96春季年会  ( 同志社大学京田辺キャンパス )   2016.3  日本化学会

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  • 海洋産ポリケチドyoshinone Aの全合成、および絶対立体配置の決定

    四宮誠一, 岩﨑有紘, 大野 修, 末永聖武

    日本化学会第96春季年会  ( 同志社大学京田辺キャンパス )   2016.3  日本化学会

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  • 海洋産マクロリドkoshikalideの全合成と絶対立体配置の決定

    国府田一樹, 長本雅司, 岩﨑有紘, 末永聖武

    日本化学会第96春季年会  ( 同志社大学京田辺キャンパス )   2016.3  日本化学会

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  • Structure of novel linear lipopeptides which contained unique fatty acid, isolated from a marine cyanobacterium. International conference

    Shinpei Sumimoto, Arihiro Iwasaki, Osamu Ohno, Toshiaki Teruya, Toshiyasu Inuzuka, Kiyotake Suenaga

    Pacifichem 2015  ( Honolulu )   2015.12 

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  • Total synthesis of kurahynes: A new acetylene-contaning lipopeptide from marine cyanobacterial assemblage. International conference

    Shinichiro Okamoto, Arihiro Iwasaki, Osamu Ohno, Kiyotake Suenaga

    Pacifichem 2015  ( Honolulu )   2015.12 

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  • Janadolide, an apoptosis-inducing cyclic lipopeptide possessing a t-Bu group from the marine cyanobacterium Okeania lorea. International conference

    Hidetoshi Ogawa, Arihiro Iwasaki, Shinpei Sumimoto, Osamu Ohno, Kiyotake Suenaga

    Pacifichem 2015  ( Honolulu )   2015.12 

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  • Synthetic study of a marine macrolide koshikalide and determination of absolute configuration. International conference

    Kazuki Kunifuda, Arihiro Iwasaki, Kiyotake Suenaga

    Pacifichem 2015  ( Honolulu )   2015.12 

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  • Kurahyne, a novel ER stress-inducer isolated from marine cyanobacterial assemblages of Lyngbya sp. International conference

    Arihiro Iwasaki, Osamu Ohno, Shinpei Sumimoto, Kiyotake Suenaga

    Pacifichem 2015  ( Honolulu )   2015.12 

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  • Yoshinone A: A novel natural product that shows an anti-obesity activity. International conference

    Yoshinori Kawazoe, Tomoyuki Koyama, Arihiro Iwasaki, Osamu Ohno, Kiyotake Suenaga, Daisuke Uemura

    Pacifichem 2015  ( Honolulu )   2015.12 

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  • 海洋シアノバクテリア由来新規小胞体ストレス誘導剤クラハインの構造，合成および作用機序解明

    岩﨑有紘, 大野修, 澄本慎平, 岡本慎一朗, 森田真布, 旦慎吾, 矢守隆夫, 末永聖武

    第57回天然有機化合物討論会  ( 神奈川県民ホール )   2015.9 

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  • 海洋生物由来新規生物活性物質の構造と生物活性

    岩﨑有紘, 大野 修, 澄本真平, 末永聖武

    日本ケミカルバイオロジー学会第10回年会  2015.6  日本ケミカルバイオロジー学会

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  • 海洋酸微細藻類由来新規リポペプチド類の構造と生物活性

    岩﨑有紘, 大野 修, 澄本慎平, 末永聖武

    新規素材探索研究会第14回セミナー  ( 新横浜フジビューホテル )   2015.6  新規素材探索研究会

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  • 海洋産ポリケチドyoshinone Aの合成研究

    四宮誠一, 岩﨑有紘, 大野 修, 末永聖武

    新規素材探索研究会第14回セミナー  ( 新横浜フジビューホテル )   2015.6  新規素材探索研究会

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  • t-Bu基を有する海洋シアノバクテリア由来新規環状リポペプチドの単離と構造決定

    小川英俊, 岩﨑有紘, 澄本慎平, 大野 修, 末永聖武

    新規素材探索研究会第14回セミナー  ( 新横浜フジビューホテル )   2015.6  新規素材探索研究会

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  • 新規鎖状リポペプチドkurahyne類の全合成

    岡本慎一朗, 岩﨑有紘, 大野 修, 末永聖武

    新規素材探索研究会第14回セミナー  ( 新横浜フジビューホテル )   2015.6  新規素材探索研究会

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  • 海洋シアノバクテリア由来新規エナミドの単離と構造決定

    澄本慎平, 岩﨑有紘, 大野 修, 末永聖武

    新規素材探索研究会第14回セミナー  ( 新横浜フジビューホテル )   2015.6  新規素材探索研究会

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  • 海洋微細藻類由来新規リポペプチドの構造および生物活性

    岩崎有紘, 大野 修, 澄本慎平, 末永聖武

    日本化学会第95春季年会  ( 日本大学船橋キャンパス )   2015.3 

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  • 新規海洋産ポリケチドyoshinone Aの合成研究

    四宮誠一, 岩崎有紘, 大野 修, 末永聖武

    日本化学会第95春季年会  ( 日本大学船橋キャンパス )   2015.3 

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  • t-Bu基を有する海洋シアノバクテリア由来新規環状リポペプチドの単離と構造決定

    小川英俊, 岩崎有紘, 澄本慎平, 大野 修, 末永聖武

    日本化学会第95春季年会  ( 日本大学船橋キャンパス )   2015.3 

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  • 特異な脂肪酸鎖をもつ海産シアノバクテリア由来新規鎖状リポペプチドの単離と構造決定

    澄本慎平, 岩崎有紘, 大野 修, 犬塚俊康, 照屋俊明, 末永聖武

    日本化学会第95春季年会  ( 日本大学船橋キャンパス )   2015.3 

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  • 鎖状デプシペプチドMaedamideの単離、構造決定および合成研究

    高柳綾乃, 岩崎有紘, 大野 修, 末永聖武

    日本化学会第95春季年会  ( 日本大学船橋キャンパス )   2015.3 

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  • 新規ペプチド化合物kurahyne類の全合成

    岡本慎一朗, 岩崎有紘, 大野 修, 末永聖武

    日本化学会第95春季年会  ( 日本大学船橋キャンパス )   2015.3 

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  • 海洋産マクロリドkoshikalideの合成研究と絶対立体配置の決定

    国府田一樹, 長本雅司, 岩崎有紘, 末永聖武

    日本化学会第95春季年会  ( 日本大学船橋キャンパス )   2015.3 

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  • 海洋シアノバクテリア由来新規小胞体ストレス誘導剤kurahyneの単離と機能解析

    大野 修, 岩崎有紘, 旦 慎吾, 矢守隆夫, 末永聖武

    第18回日本がん分子標的治療学会学術集会  ( 仙台 )   2014.6 

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  • 海洋シアノバクテリア由来新規小胞体ストレス誘導剤kurahyneの単離と機能解析

    岩﨑有紘, 大野 修, 旦 慎吾, 矢守隆夫, 末永聖武

    日本ケミカルバイオロジー学会第９回年会  ( 大阪大学 )   2014.6 

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  • 海洋シアノバクテリア由来新規小胞体ストレス誘導剤 kurahyne の単離と機能解析

    岩崎 有紘, 大野 修, 旦 慎吾, 矢守 隆夫, 末永 聖武

    新規素材探索研究会第13回セミナー  ( 新横浜 )   2014.6 

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  • 海洋シアノバクテリア由来新規小胞体ストレス誘導剤 kurahyne の単離と機能解析

    岩崎 有紘, 大野 修, 旦 慎吾, 矢守 隆夫, 末永 聖武

    化学療法基盤支援活動第3回シンポジウム  ( 名護 )   2014.5 

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  • 海洋シアノバクテリアが形成するバイオマット由来の新規生物活性物質の単離と構造

    岩崎有紘, 大野 修, 澄本慎平, 須田彰一郎, 末永聖武

    日本化学会第94春季年会  ( 名古屋大学 )   2014.3  日本化学会

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  • 海洋シアノバクテリアが形成するバイオマット由来の新規リポペプチドの単離と構造

    岩﨑有紘, 澄本慎平, 大野修, 須田彰一郎, 末永聖武

    日本農芸化学会関東支部大会  ( 慶應義塾大学 )   2013.11  日本農芸化学会関東支部

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Awards

  • 令和６年度 中央大学 学術研究奨励賞

    2025.3   中央大学  

  • 令和6年度 科学技術分野の文部科学大臣表彰 若手科学者賞

    2024.4   文部科学省   海洋ラン藻由来の新規天然物の構造と生物活性に関する研究

    岩崎 有紘

  • 第37回 若い世代の特別講演会 講演証

    2023.3   日本化学会   海洋シアノバクテリア由来新規天然物の発見とその価値の探索

    岩崎有紘

  • 第20回 天然物化学談話会奨励賞

    2021.7   天然物化学談話会・同奨励賞選考委員会   海洋シアノバクテリア由来新規天然物の発見と、その価値の探索

  • Inoue Research Award for Young Scientists

    2017.2   公益財団法人井上科学振興財団  

  • 藤原賞（藤原奨学金基金）

    2016.3   藤原奨学金基金  

  • 第57回天然有機化合物討論会 奨励賞

    2015.9  

  • 毒素シンポジウム 第62回奨励賞

    2015.7   海洋シアノバクテリア由来、新規小胞体ストレス誘導剤クラハインの単離、構造決定、作用機序解明

  • 新学術領域研究「天然物ケミカルバイオロジー」第7回若手研究者ワークショップ 優秀講演賞

    2015.6   新学術領域研究「天然物ケミカルバイオロジー」   藍藻由来新規アポトーシス誘導剤、クラハインの構造と作用機序解明

  • 日本ケミカルバイオロジー学会 第10回年会 ポスター賞

    2015.6   日本ケミカルバイオロジー学会   海洋生物由来新規生物活性物質の構造と生物活性

  • 日本化学会第95春季年会 学生講演賞

    2015.3   日本化学会   海洋微細藻類由来新規リポペプチドの構造および生物活性

    岩崎有紘

  • 新規素材探索研究会 第13回セミナー 最優秀ポスター賞

    2014.6   新規素材探索研究会   海洋シアノバクテリア由来新規小胞体ストレス誘導剤kurahyneの単離と機能解析

    岩崎有紘

  • 化学療法基盤支援活動第３回シンポジウム 優秀ポスター賞

    2014.5   文部科学省 科研費・がん支援 化学療法基盤支援活動班   海洋シアノバクテリア由来新規小胞体ストレス誘導剤kurahyneの単離と機能解析

    岩崎有紘

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Research Projects

  • 海洋生物由来新規 SERCA 阻害剤の探索

    2025.4 - 2027.3

    加藤記念バイオサイエンス振興財団  加藤記念研究助成 

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    Authorship：Principal investigator 

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  • Efficient isolation and structure determination of novel marine natural products using information science

    Grant number：24K08620  2024.4 - 2027.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)  Chuo University

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    Grant amount： \4680000 （ Direct Cost: \3600000 、 Indirect Cost： \1080000 ）

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  • 離島特有の微生物相に着目した新規天然物探索

    2023.4 - 2026.3

    内藤記念科学振興財団  内藤記念次世代育成研究助成 

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    Authorship：Principal investigator 

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  • 天然記念物テングノムギメシに関する生物有機化学的研究

    2023.1 - 2025.3

    三菱財団  自然科学研究助成 

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    Authorship：Principal investigator 

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  • Development of a platform for drug discovery by isolation and synthesis of novel natural products derived from unculturable marine cyanobacteria

    Grant number：21KK0099  2021.10 - 2025.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))  University of Tsukuba

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    Authorship：Coinvestigator(s) 

    Grant amount： \18980000 （ Direct Cost: \14600000 、 Indirect Cost： \4380000 ）

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  • 高性能計算機を活用した有用天然物探索

    2022.9 - 2024.8

    日揮・実吉奨学会  研究助成 

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    Authorship：Principal investigator 

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  • 海洋生物がもつ末端アルキン天然物のケミカルスペースの開拓

    Grant number：21K14747  2021.4 - 2024.3

    日本学術振興会  科学研究費助成事業 若手研究  若手研究  慶應義塾大学

    岩崎 有紘

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    Grant amount： \4550000 （ Direct Cost: \3500000 、 Indirect Cost： \1050000 ）

    末端アルキンをもつ海洋天然物に注目し、構造と生物活性の多様性の解明を目的とする本研究において、今年は以下に述べる実績をあげた。
    (1)構造の多様性について：真栄田岬で採集した海洋シアノバクテリアより、末端アルキンをもつ環状リポペプチドを単離した。本化合物は、ペプチド鎖と末端アルキン含有脂肪酸部からなる構造であり、脂肪酸部にはアシル化された水酸基とgemジメチル構造をもつ。ヒト子宮頸がん細胞を用いた細胞増殖阻害活性の結果、本化合物は細胞毒性を示さないことを明らかにした。現在、熱帯病原虫に対する増殖阻害活性（トリパノソーマおよびマラリア）とウイルス感染阻害活性（エボラウイルスおよびCOVID-19）の評価を実施している。また、大度海岸で採集したOkeania属海洋シアノバクテリアより、新規末端アルキン含有鎖状リポペプチドを2種単離し、オオドオケアニンAおよびBと名付けた。本化合物が脂肪細胞分化促進活性をもつこと見出した。
    (2)生物活性の多様性について：当研究室で過去に発見した末端アルキン含有リポペプチド（クラハインおよびジャハナイン）のウイルス感染阻害活性（エボラウイルスおよびCOVID-19）の評価を実施している
    (3)探索対象生物の拡張に向けた取り組みについて：探索対象生物を拡張するために実験環境を整備した。従来は海洋シアノバクテリアやカイメン、ホヤといった採集が容易で比較的大型の集合体を形成する生物をソースとしてきたが、あらたに海洋放線菌や海洋糸状菌を対象とした探索を実施するために、菌類の培養環境を構築した。現在、特定の菌類を分離するための選択培地について検討を進めており、一部の海洋放線菌についてはその分離と大量培養に成功した。現在、成分探索を実施している。
    (4)その他：末端アルキン天然物を探索する過程で7種の新規天然物を単離し、その構造と生物活性を明らかにした。

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  • 情報処理技術を駆使した医薬品候補物質の超効率的探索

    2022.12 - 2023.12

    大川情報通信基金  研究助成 

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    Authorship：Principal investigator 

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  • ビッグデータと人工知能を活用した熱帯病治療薬候補物質の探索

    2022.4 - 2023.3

    慶應義塾大学  学事振興資金 部門横断型  慶應義塾大学

    岩﨑有紘, 植草義徳

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    Authorship：Principal investigator 

    Grant amount： \1600000 （ Direct Cost: \1600000 ）

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  • 温泉藻のもつ有用天然物の網羅的探索

    2021.10 - 2022.9

    戸部眞紀財団  研究助成  慶應義塾大学

    岩﨑有紘、植草義徳

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    Authorship：Principal investigator 

    Grant amount： \1000000 （ Direct Cost: \850000 、 Indirect Cost： \150000 ）

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  • Investigation of marine natural products for the development of anti-parasite drug leads

    Grant number：18K14346  2018.4 - 2021.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Early-Career Scientists  Keio University

    Iwasaki Arihiro

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    Grant amount： \4160000 （ Direct Cost: \3200000 、 Indirect Cost： \960000 ）

    In this research project, I investigated new natural products possessing useful biological activities for the treatment of tropical diseases, such as malaria and trypanosomiasis, from marine organisms. As a result, I found twenty-two new natural products from marine cyanobacteria and clarified their anti-parasite activities. In addition, I achieved the total synthesis of eight compounds out of them and established supply routes for those precious natural products. Especially among them, I evaluated anti-parasite activities of several synthetic intermediates of iheyanone, an acyclic peptide, and clarified its structure-activity relationship. Furthermore, I established the mode of action of the biological activity of an acyclic peptide-polyketide hybrid compound, iezoside.
    <BR>
    These results were reported as twelve scientific papers, three reviews, and thirty-four presentations in academic meetings.

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  • ディープラーニングと革新的NMR手法を組み合わせた次世代型天然物探索法の開発

    2019.4 - 2020.3

    慶應義塾大学  若手研究者育成ものづくり特別事業「若手研究者の海外共同研究の推進」  慶應義塾大学

    岩﨑有紘

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    Authorship：Principal investigator 

    Grant amount： \1000000 （ Direct Cost: \1000000 ）

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  • 難培養性海洋シアノバクテリアのもつ、医薬品候補物質の生合成遺伝子クラスターの特定

    2018.4 - 2019.3

    慶應義塾大学  若手研究者育成ものづくり特別事業「若手研究者の海外共同研究の推進」  慶應義塾大学

    岩﨑有紘

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    Authorship：Principal investigator 

    Grant amount： \1000000 （ Direct Cost: \1000000 ）

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  • 海洋天然物由来、抗寄生虫活性を有する医薬品シードの探索

    2017.4 - 2018.3

    慶應義塾大学  指定研究プロジェクト 次世代先端分野探索研究  慶應義塾大学

    岩﨑有紘

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    Authorship：Principal investigator 

    Grant amount： \300000 （ Direct Cost: \300000 ）

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  • 有用海洋シアノバクテリアの生合成遺伝子の解析

    2016.4 - 2017.3

    慶応工学会  研究費援助  慶應義塾大学

    岩﨑有紘

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    Authorship：Principal investigator 

    Grant amount： \300000 （ Direct Cost: \300000 ）

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  • Elucidation of the mode of action of kurahyne, an ER-stress inducer

    Grant number：15H06584  2015.8 - 2017.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Research Activity start-up  Grant-in-Aid for Research Activity start-up  Keio University

    Iwasaki Arihiro

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    Grant amount： \2730000 （ Direct Cost: \2100000 、 Indirect Cost： \630000 ）

    Kurahyne is a marine natural product that exhibits osteoclast differentiation-inhibitory activity and sarco/endoplasmic reticulum Ca2+-ATPase (SERCA)-inhibitory activity. In this study, I have investigated the detailed mechanisms of these activities.
    As a result, we have found the following things;
    (1) Prohibitin-1 and -2 can play an important role in the osteoclast differentiation-inhibitory activity of kurahyne; (2) Specific fourteen amino-acid residues in SERCA are identified as a possible kurahyne-binding site; (3) Two kurahyne-related marine natural products were isolated, and the structure determination and the total synthesis of them were achieved. Furthermore, some knowledge regarding a structure-activity relationship was obtained.

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Committee Memberships

  • 2017.9 - Now

    天然物化学談話会世話人会   天然物化学談話会世話人  

  • 2022.12 - 2023.5

    第10回慶應有機化学若手シンポジウム実行委員会   実行委員  

  • 2020.1 - 2023.3

    毒素シンポジウム 運営事務局   運営委員  

  • 2021.12 - 2022.5

    第９回慶應有機化学若手シンポジウム実行委員会   実行委員  

  • 2017.9 - 2021.8

    慶應義塾大学理工学部化学科   広報委員  

  • 2020.5 - 2021.5

    第８回慶應有機化学若手シンポジウム実行委員会   実行委員  

  • 2019.7 - 2019.12

    日本化学会 第100春季年会 プログラム編成委員  

  • 2019.8 - 　

    中堅・若手リーダーのための YUGOKAFe（有機合成化学協会） サポーター  

  • 2018.12 - 2019.5

    第７回慶應有機化学若手シンポジウム実行委員会   委員長  

  • 2017.12 - 2018.5

    第６回慶應有機化学若手シンポジウム実行委員会   実行委員  

  • 2016.7 - 2017.7

    第52回天然物化学談話会実行委員会   実行委員  

  • 2016.12 - 2017.5

    第5回慶應有機化学若手シンポジウム実行委員会   実行委員  

  • 2016.5 - 2017.3

    日本化学会・第97春季年会   会場・総務小委員会委員  

  • 2015.12 - 2016.5

    第4回慶應有機化学若手シンポジウム実行委員会   実行委員  

  • 2015.4 - 2015.9

    第57回天然有機化合物討論会 実行委員会   実行委員  

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