Updated on 2025/07/15

写真a

 
KOMATSU Teruyuki
 
Organization
Faculty of Science and Engineering Professor
Other responsible organization
Applied Chemistry Course of Graduate School of Science and Engineering, Master's Program
Applied Chemistry Course of Graduate School of Science and Engineering, Doctoral Program
Contact information
The inquiry by e-mail is 《here》
Homepage
https://komatsu-lab.r.chuo-u.ac.jp/en/
External link

Degree

  • Ph.D. ( Waseda University )

  • ME ( Waseda University )

Education

  • 1994.3
     

    Waseda University   Graduate School, Division of Science and Engineering   Department of Applied Chemistry   doctor course   completed

  • 1990.3
     

    Waseda University   Graduate School, Division of Science and Engineering   Department of Applied Chemistry   master course   completed

  • 1988.3
     

    Waseda University   Faculty of Science and Engineering   Department of Applied Chemistry   graduated

Research History

  • 2010.4 - Now

    Chuo University   Department of Applied Chemistry   Professor

  • 2022.4 - 2022.9

    Charité-Universitätsmedizin Berlin   Guest Professor

  • 2002.9 - 2015.3

    Keio University   Medical School   Visiting Professor

  • 2006.10 - 2010.3

    PRESTO, JST   Structure Control and Function   Researcher

  • 2006.10 - 2010.3

    Waseda University   Research Institute for Sci. & Eng.   Associate Professor

  • 2003.11 - 2010.3

    Imperial College London   Visiting scholar

  • 1997.4 - 2006.9

    Waseda University   Advanced Research Institute for Sci. & Eng.   Associate Professor

  • 1995.4 - 1997.3

    Free University of Berlin   Institute of Organic Chemistry   JSPS Fellow for Research Abroad

  • 1993.10 - 1995.3

    Waseda University   Graduate School of Sci. & Eng.   JSPS Fellow

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Professional Memberships

  • 日本化学連合

  • American Chemical Society

  • 日本医工学治療学会

  • 日本血液代替物学会

  • 錯体化学会

  • 高分子学会

  • The Chemical Society of Japan

▼display all

Research Interests

  • Micromotors

  • Artificial blood

  • Biomaterials

  • Porophyrin

  • Protein

  • Anticancer agents

  • hemoproteins

  • Artificial red blood cells

Research Areas

  • Nanotechnology/Materials / Nanomaterials  / Micro/nanomaterials chemistry

  • Nanotechnology/Materials / Chemistry and chemical methodology of biomolecules  / Biomolecular Chemistry

  • Nanotechnology/Materials / Polymer chemistry  / Polymer chemistry

  • Nanotechnology/Materials / Inorganic/coordination chemistry  / Bioinorganic chemistry

  • Nanotechnology/Materials / Bio chemistry  / Bio-related Chemistry

Papers

  • Polymerized Stroma-Free Hemoglobin Nanoparticle Covalently Coated with Poly(2-ethyl-2-oxazoline) as a Red Blood Cell Substitute Reviewed

    N. Kohyama, T. Araki, M. Fujita, J. Fujisawa, T. Yamada, M. Yamaguchi, M. Kohno, T. Komatsu

    <I>Eur. Polym. J.</I>   236   114126:1 - 9   2025.8

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  • Tubular Micromotors Functionalized with Doxorubicin-Loaded Liposomes for Drug Delivery and Light-Triggered Release Reviewed

    S. Batori, T. Komatsu

    <I>ACS Appl. Nano Mater.</I>   8 ( 23 )   11763 - 11768   2025.6

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  • Nanoparticle O2 Carrier Composed of a Polymerized Stroma-Free Hemoglobin Core and Serum Albumin Shell as a Red Blood Cell Alternative in Hemorrhagic Shock Therapy Reviewed

    N. Kohyama, K. Takamine, W. Okamoto, T. Yamada, M. Yamaguchi, M. Kohno, R. Tochinai, T. Komatsu

    <I>ACS Appl. Bio Mater.</I>   8 ( 3 )   2397 - 2407   2025.3

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    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：American Chemical Society (ACS)  

    DOI： 10.1021/acsabm.4c01901

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  • Synthesis and Physicochemical Properties of Poly(2‐Alkyl‐2‐Oxazoline)‐Conjugated Hemoglobins as an Artificial O2 Carrier: Comparison with Polyethylene Glycol Conjugates Reviewed

    R. Wakabayashi, K. Ishii, T. Yamada, T. Komatsu

    <I>Macromol. Chem. Phys.</I>   226 ( 4 )   2400183 - 1-7   2025.2

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    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    Abstract

    Polyethylene glycol (PEG) is a biocompatible polymer extensively employed to prolong blood circulation and mitigate the immunogenicity of the protein therapeutics. Nonetheless, there are reports of anti‐PEG antibody production. Poly(2‐alkyl‐2‐oxazoline) (PROx) exhibits analogous immunological stealth properties and represents a potential substitute for PEG. This study details the synthesis of PROx‐conjugated hemoglobins (PROxm‐Hbs, R = Me, Et) as artificial O2 carriers, functioning as red blood cell (RBC) substitutes, and evaluates their O2 affinities and solution properties. The average number of polymers bound is designed to be 6 or 11. The O2 affinities (P50) of PMeOxm‐Hbs and PEtOxm‐Hbs are ascertained as 9 Torr, comparable to those of PEG‐conjugated Hbs (PEGm‐Hbs). The PEtOx6‐HbT, synthesized under an N2 atmosphere, exhibited a low O2 affinity (P50 = 57 Torr). Through the admixture of PEtOx6‐Hb and PEtOx6‐HbT, the P50 value of the formulation to range from 9 to 57 Tor can be tailored as desired. The colloid osmotic pressures and viscosities of PMeOxm‐Hb and PEtOxm‐Hb solutions are lower than those of the corresponding PEGm‐Hb solutions. Furthermore, the PROx conjugates evinced no cytotoxicity against normal cells. PMeOxm‐Hbs and PEtOxm‐Hbs, characterized by their appropriate O2 affinities and solution properties, present themselves as promising alternative materials to RBCs.

    DOI： 10.1002/macp.202400183

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  • Hydrosulfide-methaemoglobin-albumin cluster: A hydrogen sulfide donor Reviewed

    Yuto Suzuki, Taiga Yamada, Yuki Enoki, Kazuaki Matsumoto, Teruyuki Komatsu, Kazuaki Taguchi

    <I>J. Mater. Chem. B</I>   12 ( 44 )   11511 - 11522   2024.11

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Royal Society of Chemistry (RSC)  

    Methaemoglobin (metHb) possesses inherent characteristics that facilitate reversible binding to hydrogen sulfide. Exogenous hydrogen sulfide supplementation imparts beneficial bioactive effects, including antioxidant and anti-inflammatory; hence, we hypothesized that the metHb-hydrogen...

    DOI： 10.1039/d4tb01621a

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  • Self-Propelled Tubular Micromotors Powered by Hydrogen Bubbles under Mild Conditions: A Major Step toward Biological Applications with Live Cells Reviewed

    M. Hashimoto, Y. Sakai, T. Yamada, R. Kato, T. Komatsu

    <I>ACS Appl. Bio Mater.</I>   7 ( 11 )   7740 - 7747   2024.11

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    DOI： 10.1021/acsabm.4c01350

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  • Transport of Zinc‐Phthalocyanine to Cancer Cells Using Myoglobin−Albumin Fusion Protein for Photodynamic Therapy Reviewed

    T. Yamada, M. Funamoto, R. Takada, Y. Morita, T. Komatsu

    ChemBioChem   25 ( 17 )   e202400329 - 1-7   2024.9

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    Abstract

    Photodynamic therapy (PDT) is a noninvasive approach to cancer treatment, wherein cell death is initiated by singlet oxygen (1O2) production via energy transfer from excited photosensitizers to ground‐state O2. Effective clinical photosensitizers necessitate water solubility for in vivo administration. Hydrophobic dyes, such as phthalocyanines, cannot be used directly as photosensitizers. Herein, we synthesized a myoglobin‐(human serum albumin) fusion protein reconstituted with zinc‐phthalocyanine (ZnPc), termed ZnPcMb‐HSA. The photophysical properties of ZnPcMb‐HSA closely resemble those of ZnPc‐substituted Mb. Notably, ZnPc dissociates from ZnPcMb‐HSA and selectively accumulates within cancer cells, while the protein components remain extracellular. Treatment of four distinct cell lines with ZnPcMb‐HSA, followed by red‐light irradiation, effectively induced apoptosis. The half‐maximal inhibitory concentrations (IC50) against these cancer cell lines ranged between 0.1–0.5 μM. Reconstituted Mb‐HSA emerges as a promising carrier for transporting various water‐insoluble porphyrinoid photosensitizer to target cancer cells in PDT applications.

    DOI： 10.1002/cbic.202400329

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  • Dual Delivery of Carbon Monoxide and Doxorubicin Using Haemoglobin–Albumin Cluster: Proof of Concept for Well-Tolerated Cancer Therapy [Front Cover] Reviewed

    C. Ito, K. Taguchi, T. Yamada, K. Hanaya, Y. Enoki, T. Sugai, T. Komatsu, K. Matsumoto

    J. Mater. Chem. B   12 ( 23 )   5600 - 5608   2024.6

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Royal Society of Chemistry (RSC)  

    The dual delivery of CO and DOX using HemoAct is a promising strategy as an anti-tumour agent to realise well-tolerated cancer therapy with minimal cardiotoxicity.

    DOI： 10.1039/d4tb00123k

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  • Zinc‐Substituted Hemoglobin–Albumin Cluster as a Porphyrin‐Carrier for Enhanced Photodynamic Therapy Reviewed

    T. Yamada, M. Katsumi, K. Ishii, T. Komatsu

    Chem. Asian J.   19 ( 11 )   e202400257:1 - 8   2024.6

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    Abstract

    Apohemoprotein is focused on the field of theranostics, serving as a porphyrin carrier. Hemoglobin (Hb) consists of α2β2 tetramer with iron(II)‐protoporphyrin IX (heme) bound to each globin. However, heme‐removed Hb (apoHb) causes dissociation at αβ interfaces and aggregation under physiological conditions. We synthesized a stable apoHb derivative comprising intramolecular‐crosslinked apoHb (apoXHb) and human serum albumin (HSA), apoXHb‐HSA3. ApoXHb‐HSA3 engendered no aggregates in the physiological solutions. Moreover, apoXHb‐HSA3 was reconstituted with zinc(II)‐protoporphyrin IX (ZnP), generating ZnXHb‐HSA3, a potent photosensitizer for photodynamic therapy (PDT). The photophysical properties of ZnXHb‐HSA3 were identical to those of zinc‐substituted XHb (ZnXHb). Cellular uptake behavior was evaluated using various cancer cell lines. ZnXHb‐HSA3 released ZnP around the cells, and the free ZnP penetrated cell membranes. In contrast, protein units were not observed within the cells. ZnXHb‐HSA3 showed no cytotoxicity under dark conditions and demonstrated superior PDT activity in comparison to naked ZnXHb. ZnXHb‐HSA3 acts as an innovative porphyrin carrier for enhanced PDT.

    DOI： 10.1002/asia.202400257

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  • Photocurable Acrylic-Resin-Based Tubular Micromotors with Smart External Surfaces Reviewed

    M. Hashimoto, Y. Akashi, Y. Sakai, T. Sugawara, R. Kato, B. Schade, K. Ludwig, T. Komatsu

    ACS Appl. Polym. Mater.   6 ( 10 )   5822 - 5832   2024.5

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    DOI： 10.1021/acsapm.4c00486

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  • Acrylic-Resin-Based Tubular Micromotors Bearing Magnetic Nanoparticles and Enzymes Driven by Visible Light Irradiation: Implications for Accelerating Reactions and Cargo Transport Reviewed

    S. Batori, T. Komatsu

    ACS Appl. Nano Mater.   7 ( 7 )   6804 - 6809   2024.4

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    DOI： 10.1021/acsanm.4c01103

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  • Polyoxazoline-Conjugated L-Asparaginase: An Antibody-Production-Free Therapeutic Agent for Acute Lymphoblastic Leukemia Reviewed

    T. Yamada, M. Ishimaru, Ta. Shoji, H. Tomiyasu, R. Tochinai, K. Taguchi, T. Komatsu

    ACS Applied Bio Materials   6 ( 12 )   5789 - 5797   2023.12

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    DOI： 10.1021/acsabm.3c00888

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  • Neuroprotective Effects of a Hemoglobin-Based Oxygen Carrier (Stroma-Free Hemoglobin Nanoparticle) on Ischemia Reperfusion Injury Reviewed

    R. Tatezawa, T. Abumiya, Y. Ito, M. Gekka, W. Okamoto, K. Ishii, N. Kohyama, T. Komatsu, M. Fujimura

    Brain Res.   1821   148953:1 - 10   2023.12

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    DOI： 10.1016/j.brainres.2023.148592

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  • Protein–Porphyrin Complex Photosensitizers for Anticancer and Antimicrobial Photodynamic Therapies [Short Review] Invited Reviewed

    T. Yamada, T. Komatsu

    ChemMedChem   18   e202300373:1 - 8   2023.12

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    Photodynamic therapy (PDT) efficiently induces apoptosis through visible‐light irradiation of photosensitizers (PSs) within tumors and microbial cells. Porphyrin analogues serve as widely utilized photosensitizing agents with their theranostic abilities being governed by molecular structures and central metal ions. However, these macrocyclic compounds tend to agglutinate and form stacks in aqueous environments, resulting in a loss of photochemical activity. To overcome this limitation, encapsulation within liposomes and polymer micelles enables the dispersion of porphyrins as monomolecular entities in aqueous solutions, preventing undesirable deactivation. Recently, the use reconstituted hemoproteins containing various metal‐porphyrins and protein cages incorporating porphyrins have garnered significant interest as a new generation of biocompatible PSs. In this concept paper, we provide a comprehensive review of recent developments and trends of protein–porphyrin complex PSs for applications in anticancer and antimicrobial PDTs.

    DOI： 10.1002/cmdc.202300373

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  • Pharmaceutical Stability of Methemoglobin-Albumin Cluster as an Antidote for Hydrogen Sulfide Poisoning after One-Year Storage in Freeze-Dried Form Reviewed

    Y. Suzuki, K. Taguchi, W. Okamoto, Y. Enoki, T. Komatsu, K. Matsumoto

    Int. J. Pharm.   645   123433:1 - 8   2023.10

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    DOI： 10.1016/j.ijpharm.2023.123433

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  • Poly(2-ethyl-2-oxazoline)-Conjugated Hemoglobins as a Red Blood Cell Substitute. Reviewed International journal

    W. Okamoto, Y. Hiwatashi, T. Kobayashi, Y. Morita, H. Onozawa, M. Iwazaki, M. Kohno, H. Tomiyasu, R. Tochinai, R.Georgieva, H. Bäumler, T. Komatsu

    ACS Appl. Bio Mater.   6 ( 8 )   3330 - 3340   2023.8

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    Hemoglobin wrapped covalently with poly(2-ethyl-2-oxazoline)s (POx-Hb) is characterized physicochemically and physiologically as an artificial O2 carrier for use as a red blood cell (RBC) substitute. The POx-Hb is generated by linkage of porcine Hb surface-lysines to a sulfhydryl terminus of the POx derivative, with the average binding number of the polymers ascertained as 6. The POx-Hb shows moderately higher colloid osmotic activity and O2 affinity than the naked Hb. Human adult HbA conjugated with POx also possesses equivalent features and O2 binding properties. The POx-Hb solution exhibits good hemocompatibility, with no influence on the functions of platelets, granulocytes, and monocytes. Its circulation half-life in rats is 14 times longer than that of naked Hb. Hemorrhagic shock in rats is relieved sufficiently by infusion of the POx-Hb solution, as revealed by improvements of circulatory parameters. Serum biochemistry tests and histopathological observations indicate no acute toxicity or abnormality in the related organs. All results indicate that POx-Hb represents an attractive alternative for RBCs and a useful O2 therapeutic reagent in transfusion medicine.

    DOI： 10.1021/acsabm.3c00392

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  • Pharmaceutical Integrity of Lyophilized Methemoglobin-Albumin Clusters after Reconstitution Reviewed

    Y. Suzuki, K. Taguchi, W. Okamoto, Y. Enoki, T. Komatsu, K. Matsumoto

    ACS Omega   8 ( 25 )   22589 - 22595   2023.6

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    DOI： 10.1021/acsomega.3c01054

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  • Polyoxazoline-Conjugated Porcine Serum Albumin as an Artificial Plasma Expander for Dogs Reviewed

    W. Okamoto, T. Usui, M. Hasegawa, T. Kobayashi, J. Fujisawa, K. Taguchi, K. Matsumoto, M. Kohno, M. Iwazaki, S. Shimano, I. Nagao, H. Toyoda, N. Matsumura, H. Tomiyasu, R. Tochinai, T. Komatsu

    Sci. Rep.   13   9512:1 - 15   2023.6

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    DOI： 10.1038/s41598-023-35999-4

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  • O2 Affinities of Hemoglobin Variants Having a Different Amino Acid at the Position α99 Reviewed

    Y. Morita, R. Yoshida, A. Saito, T. Komatsu

    Chem. Lett.   52 ( 5 )   325 - 328   2023.5

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    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：The Chemical Society of Japan  

    DOI： 10.1246/cl.230105

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  • Methemoglobin-Albumin Clusters as a Cyanide Detoxification Protein Reviewed

    Y. Suzuki, K. Taguchi, W. Okamoto, Y. Enoki, T. Komatsu, K. Matsumoto

    Toxicol. Appl. Pharmacol.   466   116472:1 - 7   2023.5

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  • Zinc Substituted Myoglobin−Albumin Fusion Protein: A Photosensitizer for Cancer Therapy Reviewed

    T. Yamada, Y. Morita, R. Takada, M. Funamoto, W. Okamoto, M.Kohno, T. Komatsu

    Chemistry Eur. J.   29 ( 22 )   e202203952:1 - 7   2023.4

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    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    Abstract

    Myoglobin combined with human serum albumin (Mb‐HSA) can be produced using yeast Pichia pastoris as a host strain, with secretion into the culture medium. This Mb‐HSA fusion protein possesses identical O2 binding affinity to that of naked Mb. The Mb unit is reconstituted with a zinc(II) protoporphyrin IX, yielding (zinc substituted Mb)‐HSA, ZnMb‐HSA. The photophysical property and singlet O2 generation ability of ZnMb‐HSA are equivalent to those of ZnMb. In vitro cell experiments revealed that ZnMb‐HSA acts as a superior photosensitizer for photodynamic cancer therapy. It is noteworthy that ZnMb‐HSA shows long circulation lifetime in vivo.

    DOI： 10.1002/chem.202203952

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    Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/chem.202203952

  • Core-Shell Structured Hemoglobin Nanoparticles as Artificial O2 Carriers Reviewed International journal

    W. Okamoto, M. Hasegawa, N. Kohyama, T. Kobayashi, T. Usui, H. Onozawa, R. Hashimoto, M. Iwazaki, M. Kohno, R. Georgieva, H. Bäumler, T. Komatsu

    ACS Appl. Bio Mater.   5 ( 12 )   5844 - 5853   2022.12

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    This paper describes the synthesis and O2 binding properties of core-shell structured hemoglobin (Hb) nanoparticles (NPs), artificial O2 carriers of five types, as designed for use as red blood cell (RBC) substitutes. Human adult Hbs were polymerized using α-succinimidyl-ω-maleimide and dithiothreitol in spheroidal shapes to create parent particles. Subsequent covalent wrapping of the sphere with human serum albumin (HSA) yielded 100 nm-diameter Hb nanoparticles (HbNPs). The HbNP showed higher O2 affinity than that of RBC, but NPs prepared under a N2 atmosphere exhibited low O2 affinity. Entirely synthetic particles comprising recombinant human adult Hb and recombinant HSA were also fabricated. Using a recombinant Hb (rHb) variant in which Leu-β28 of the heme pocket had been replaced with Phe, we found somewhat low O2 affinity of rHb(βL28F)NP. Particles made of stroma-free Hb (SFHb) containing natural antioxidant enzyme catalase (SFHbNP) formed a very stable O2 complex, even in aqueous H2O2 solution. The SFHbNP showed good blood compatibility and did not affect the blood cell component functionality. The circulation half-life of SFHbNP in rats was considerably longer than that of naked Hb. All results indicate these Hb-based NPs as useful alternative materials for RBC and as a useful O2 therapeutic reagent in diverse medical scenarios.

    DOI： 10.1021/acsabm.2c00813

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  • Swimming Protein Microtube Motors Capture Virus-Shaped Fluorescent Nanoparticles Reviewed

    Y. Akashi, N. Sugai, R. Kato, T. Komatsu

    Mater. Adv.   3 ( 18 )   6988 - 6992   2022.9

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    Swimming protein microtube motors with an exterior surface of fetuin and an interior surface of catalase captured virus-shaped fluorescent nanoparticles (100 nm-diameter), non-infectious fake influenza A viruses, efficiently.

    DOI： 10.1039/d2ma00566b

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  • Methemoglobin–Albumin Clusters for the Treatment of Hydrogen Sulfide Intoxication Reviewed

    Y. Suzuki, K. Taguchi, W. Okamoto, Y. Enoki, T. Komatsu, K. Matsumoto

    J. Control. Release   349   304 - 314   2022.9

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    DOI： 10.1016/j.taap.2023.116472

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  • Development of (Hemoglobin-Albumin)Cluster Type Artificial O2 Carriers Invited Reviewed

    T. Komatsu

    Membrane   47 ( 5 )   252 - 256   2022.9

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    Authorship：Corresponding author   Language：Japanese   Publishing type：Research paper (scientific journal)  

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  • Catalase–Albumin Cluster Incorporating Protoporphyrin IX: O2 Generating Photosensitizer for Enhanced Photodynamic Therapy Reviewed

    T. Yamada, M. Katsumi, Y. Yagisawa, M. Ichihara, T. Komatsu

    Mater. Adv.   3 ( 16 )   6451 - 6457   2022.8

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    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Royal Society of Chemistry (RSC)  

    Catalase enwrapped covalently with human serum albumin incorporating protoporphyrin IX is a unique dual functional hemoprotein cluster (O2 generation and photosensitization) that can achieve enhanced photodynamic therapy.

    DOI： 10.1039/D2MA00242F

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  • Hemoglobin-Albumin Clusters as an Artificial O2 Carrier: Physicochemical Properties and Resuscitation from Hemorrhagic Shock in Rats Reviewed International journal

    W. Okamoto, M. Hasegawa, T. Usui, T. Kashima, S. Sakata, T. Hamano, H. Onozawa, R. Hashimoto, M. Iwazaki, M. Kohno, T. Komatsu

    J. Biomed. Mater. Res.   110 ( 8 )   1827 - 1838   2022.8

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    A bovine hemoglobin (HbBv) or human adult hemoglobin (HbA) wrapped covalently by human serum albumins (HSAs), hemoglobin-albumin clusters (HbBv-HSA3 and HbA-HSA3 ), are artificial O2 carriers used as a red blood cell substitute. This article describes the physicochemical properties of the HbBv-HSA3 and HbA-HSA3 solutions, and their abilities to restore the systemic condition after resuscitation from hemorrhagic shock in anesthetized rats. The HbBv-HSA3 and HbA-HSA3 , which have high colloid osmotic activity, showed equivalent solution characteristics and O2 binding parameters. Shock was induced by 50% blood withdrawal. Rats exhibited hypotension and significant metabolic acidosis. After 15 min, the rats were administered shed autologous blood (SAB), HbBv-HSA3 , HbA-HSA3 , or Ringer's lactate (RL) solution. Survival rates, circulation parameters, hematological parameters, and blood gas parameters were monitored during the hemorrhagic shock and for 6 h after administration. All rats in the SAB, HbBv-HSA3 , and HbA-HSA3 groups survived for 6 h. The HbBv-HSA3 and HbA-HSA3 groups restored mean arterial pressure after the resuscitation. No remarkable difference was observed in the time courses of blood gas parameters in any resuscitated group except for the RL group. Serum biochemical tests showed increases in aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in the HbBv-HSA3 and HbA-HSA3 groups compared to the SAB group. Therefore, we observed other rats awakened after resuscitation with HbA-HSA3 for 7 days. The blood cell count, AST, and ALT recovered to the baseline values by 7 days. All the results implied that HbBv-HSA3 and HbA-HSA3 clusters provide restoration from hemorrhagic shock as an alternative material for SAB transfusion.

    DOI： 10.1002/jbm.b.35040

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  • Protein Triad Comprising Genetically Fused Hemoglobin and Human Serum Albumins as an Artificial O2 Carrier Resistant to Haptoglobin Binding Reviewed

    Y. Morita, Y. Shindo, T. Komatsu

    Chem. Lett.   50 ( 12 )   2011 - 2014   2021.12

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    DOI： 10.1246/cl.210549

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  • Polyelectrolyte/Gold Nanoparticle Nanotubes Incorporating Doxorubicin-Loaded Liposomes Reviewed

    Y. Enomoto, M. Akiyama, Y. Morita, T. Komatsu

    Chem. Asian J.   16 ( 24 )   4057 - 4061   2021.12

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  • Catalase-Driven Protein Microtube Motors with Different Exterior Surfaces as Ultrasmall Biotools Reviewed

    M. Umebara, N. Sugai, K. Murayama, T. Sugawara, Y. Akashi, Y. Morita, R. Kato, T. Komatsu

    Mater. Adv.   2 ( 19 )   6428 - 6438   2021.10

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    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Royal Society of Chemistry (RSC)  

    We report the synthesis of catalase-driven protein microtube motors with different exterior surfaces. Their abilities of bacteria capture, reaction enhancement by self-stirring, and velocity control with light irradiation were highlighted.

    DOI： 10.1039/d1ma00610j

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  • Genetically and Chemically Tuned Haemoglobin-Albumin Trimers with Superior O2 Transport Efficiency Reviewed

    Y. Morita, R. Takada, A. Saito, T. Komatsu

    Chem. Commun.   57 ( 72 )   9144 - 9147   2021.9

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    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Royal Society of Chemistry (RSC)  

    Genetically and chemically tuned haemoglobin–albumin trimers demonstrated haemoglobin allostery and moderately low O2 affinity, resulting in a higher O2 transport efficiency compared to red blood cells.

    DOI： 10.1039/d1cc03684j

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  • Methemoglobin‒Albumin Cluster Incorporating Protoporphyrin IX: Dual Functional Protein Drug for Photodynamic Therapy Reviewed

    T. Yamada, T. Komatsu

    ChemBioChem   22 ( 15 )   2526 - 2529   2021.8

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    DOI： 10.1002/cbic.202100213

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  • Halogen-Bonding-Donor Catalyzed Cyanosilylation of Aldehydes” Reviewed

    K. Ueyama, S. Hayakawa, K. Nishio, D. Sawaguchi, K. Niitsuma, S. Michii, R. Tsuruoka, M. Ozawa, K. Torita, Y. Morita, T. Komatsu, R. Haraguchi, S.-I. Fukuzawa

    Asian J. Org. Chem.   10 ( 7 )   1742 - 1747   2021.7

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    DOI： 10.1002/ajoc.202100184

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  • Acid Mediated Sulfonylthiolation of Arenes via Selective Activation of SS-Morpholino Dithiosulfonate Reviewed

    K. Kanemoto, K. Furuhashi, Y. Morita, T. Komatsu, S. Fukuzawa

    Org. Lett.   23 ( 5 )   1582 - 1587   2021.3

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  • Rectangular Holes in Porphyrin Isomers Act as Mono- and Bi-Nucleating Ligans: Stereochemistry of Mono- and Diboron Porphycenes and Their Protonation Behaviors Reviewed

    N. Xu, T. Ono, Y. Morita, T. Komatsu, Y. Hisaeda

    Inorg. Chem.   60 ( 2 )   574 - 583   2021.1

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    DOI： 10.1021/acs.inorgchem.0c01266

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  • Supramolecular Linear Coordination Polymers of Human Serum Albumin and Haemoglobin Reviewed

    R. Adachi, S. Suzuki, T. Mitsuda, Y. Morita, T. Komatsu

    Chem. Commun.   56 ( 99 )   15585 - 15588   2020.12

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    DOI： 10.1039/D0CC07167F

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  • Neuroprotective Effects of Combination Therapy of Regional Cold Perfusion and Hemoglobin-Based Oxygen Carrier Administration on Rat Transient Cerebral Ischemia Reviewed International journal

    Y. Ito, T. Abumiya, T. Komatsu, R. Funaki, M. Gekka, K. Kurisu, T. Sugiyama, M. Kawabori, T. Osanai, N. Nakayama, K. Kazumata, K. Houkin

    Brain Res.   1746 ( 147012 )   1 - 8   2020.11

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    Regional cold perfusion and hemoglobin-based oxygen carrier administration both exert neuroprotective effects against cerebral ischemia reperfusion injury. We herein investigated whether the combination of these two therapies leads to stronger neuroprotective effects. Combination therapy was performed with the regional perfusion of cold HemoAct, a core-shell structured hemoglobin-albumin cluster, in a rat transient middle cerebral artery occlusion model. The effects of combination therapy, the intra-arterial administration of 10 °C HemoAct (10H) initiated at the onset of reperfusion, were compared with those of monotherapies, the intra-arterial administration of 10 °C saline (10S) and 37 °C HemoAct (37H), and an untreated control under the condition of 2-hour ischemia/24-hour reperfusion. The durability of therapeutic effects and the therapeutic time window of combination therapy were assessed based on comparisons with the 10H and control groups. Significantly better neurological findings and smaller infarct volumes were observed in the three treated (10S, 37H, and 10H) groups than in the control group. Among the 3 treated groups, only the 10H group showed significant improvements over the control group in the other items examined, including cerebral blood flow reduction, brain edema, and protein extravasation. The significant therapeutic effects of combination therapy on neurological disabilities and infarct volumes were confirmed at least until 7 days after reperfusion. Furthermore, combination therapy ameliorated neurological disabilities and hemorrhagic transformation in rats subjected to 4- and 5-hour ischemia/24-hour reperfusion. Since therapeutic effects may be expected until at least 5 h of complete ischemia and reperfusion, this combination therapy is a promising neuroprotective strategy against severe ischemic stroke.

    DOI： 10.1016/j.brainres.2020.147012

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  • Protein-Based Smart Microtubes and Nanotubes as Ultrasmall Biomaterials [Highlight Review, Front Cover, Inside Cover] Invited Reviewed

    T. Komatsu

    Chem. Lett.   49 ( 10 )   1245 - 1255   2020.10

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    DOI： 10.1246/cl.200433

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  • Self-Propelled Protein Microtube Motors in Water Invited Reviewed

    T. Komatsu

    Polymers   69 ( 9 )   478 - 479   2020.9

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  • Hemoglobin(βK120C)‒Albumin Trimer as Artificial O2 Carrier with Sufficient Hemoglobin Allostery [Cover Image] Reviewed

    Y. Morita, A. Saito, J. Yamaguchi, T. Komatsu

    RSC Chem. Biol.   1 ( 3 )   128 - 136   2020.8

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    <p>Recombinant haemoglobin [rHb(βK120C)] was coupled with two human serum albumins (HSAs), yielding a rHb(βK120C)–HSA2 heterotrimer, which shows a sigmoidal O2 equilibrium curve and sufficient Hb allostery identical to those of native Hb.</p>

    DOI： 10.1039/d0cb00056f

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  • Lewis Acid–Base Synergistic Catalysis of Cationic Halogen-Bonding-Donors with Nucleophilic Counter Anions Reviewed

    K. Torita, R. Haraguchi, Y. Morita, S. Kemmochi, T. Komatsu, S. Fukuzawa

    Chem. Commun.   56 ( 67 )   9715 - 9718   2020.8

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  • Lyophilized hemoglobin-albumin cluster with disaccharides: Long-term storable powder of artificial O2-carrier

    Ryosuke Funaki, Hitomi Iwasaki, Tomonori Kashima, Teruyuki Komatsu

    Polymers for Advanced Technologies   31 ( 5 )   1122 - 1126   2020.5

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    DOI： 10.1002/pat.4846

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  • Liophilized Hemoglobin-Albumin Cluster with Disaccharides: Long-Term Storable Powder of Artificial O2 Carrier Reviewed

    R. Funaki, H. Iwasaki, T. Kashima, T. Komatsu

    Polym. Adv. Technol.   31 ( 5 )   1139 - 1145   2020.5

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  • Genetically Engineered Haemoglobin Wrapped Covalently with Human Serum Albumins as an Artificial O2 Carrier [Cover Image]) Reviewed

    R. Funaki, W. Okamoto, C. Endo, Y. Morita, K. Kihira, T. Komatsu

    J. Mater. Chem. B   8 ( 6 )   1139 - 1145   2020.2

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    DOI： 10.1039/C9TB02184A

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  • Protein Nanoparticles Formed by Self-Assembly of Human Serum Albumin with a Fatty Acid Arm [Inside Cover] Reviewed

    Y. Morita, D. Takahashi, T. Komatsu

    Chem. Lett.   49 ( 1 )   103 - 106   2020.1

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  • Nonbubble-Propelled Biodegradable Microtube Motors Consising Only of Protein Reviewed

    N. Sugai, Y. Morita, T. Komatsu

    Chem. Asian J.   14 ( 17 )   2953 - 2957   2019.9

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    DOI： 10.1002/asia.201900927

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  • Protein Microtube Motors with a Pt Nanoparticle Interior and Avidin Exterior for Self-Propelled Transportation, Separation, and Stirring [Cover Image] Reviewed

    Y. Nakai, N. Sugai, H. Kusano, Y. Morita, T. Komatsu

    ACS Appl. Nano Mater.   2 ( 8 )   4891 - 4899   2019.8

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    DOI： 10.1021/acsanm.9b00850

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  • Hemoglobin(βC93A)‒Albumin Cluster: Mutation of Cysteine-β93 to Alanine Allows Moderate Reduction of O2 Affinity by Inositol Hexaphosphate Reviewed

    Y. Morita, K. Igarashi, R. Funaki, T. Komatsu

    ChemBioChem   20 ( 13 )   1684 - 1687   2019.6

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  • Further Evidence Regarding the Important Role of Chlorine Atoms of Aripiprazole on Binding to the Site II Area of Human Albumin Reviewed

    K. Sakurama, K. Nishi, S. Imoto, M. Hashimoto, T. Komatsu, Y. Morita, K. Taguchi, M. Otagiri, K. Yamasaki

    J. Pharm. Sci.   108 ( 5 )   1890 - 1895   2019.5

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    DOI： 10.1016/j.xphs.2018.11.045

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  • 酵素反応で自走する蛋白質マイクロチューブモーター ーバイオメディカル領域での応用を目指して Invited Reviewed

    小松晃之, 菅井夏穂

    Chemistry   74 ( 4 )   66 - 67   2019.3

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  • Hemoglobin‒Albumins Clusters Prepared using N-Succinimidyl 3-Maleimidopropionateas as an Appropriate Crosslinker Reviewed

    R. Funaki, T. Kashima, W. Okamoto, S. Sakata, Y. Morita, M. Sakata, T. Komatsu

    ACS Omega   4 ( 2 )   3228 - 3233   2019.2

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    DOI： 10.1021/acsomega.8b03474

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  • Physicochemical Properties and Crystal Structures of Recombinant Canine and Feline Serum Albumins Invited Reviewed

    T. Komatsu, K. Kihira, K. Yamada, K. Yokomaku, M. Akiyama, Y. Morita

    Int. J. Microgravity Sci. Appl.   36 ( 1 )   306104:1 - 6   2019.1

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    Serum albumin is the most prominent plasma protein in the blood circulatory system and is the main transporter of various compounds. Although ligand binding ability and crystal structure of human serum albumin (HSA) have been widely studied, there are only few reports on serum albumins of companion animals, particularly dogs and cats. This review describes the synthesis, physicochemical properties, and crystal structures of recombinant canine serum albumin (rCSA) and feline serum albumin (rFSA). The rCSA and rFSA were produced in a gram quantity by genetic engineering procedure using Pichia yeast. The proteins show identical features to those of the native CSA and FSA derived from canine and feline plasma. Single crystals of rFSA were prepared under a microgravity environment in the International Space Station. The overall structures of rCSA and rFSA closely resemble to that of HSA. These recombinant serum albumins are anticipated for use as a therapeutic reagent that can be exploited in numerous veterinary medicine situations.

    DOI： 10.15011//jasma.36.360104

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  • Quaternary Structure Analysis of a Hemoglobin Core in Hemoglobin–Albumin Cluster Reviewed

    Y. Morita, T. Yamada, M. Kureishi, K. Kihira, T. Komatsu

    J. Phys. Chem. B   122 ( 50 )   12031 - 12039   2018.12

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    DOI： 10.1021/acs.jpcb.8b10077

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  • Hemoglobin–Albumin Cluster: Physiological Responses after Exchange Transfusion into Rats and Blood Circulation Persistence in Dogs Reviewed International journal

    H. Iwasaki, K. Yokomaku, M. Kureishi, K. Igarashi, R. Hashimoto, M. Kohno, M. Iwazaki, R. Haruki, K. Asai, Y. Nakamura, M. Akiyama, Y. Morita, T. Komatsu

    Artif. Cells Nanomed. Biotechnol.   46 ( S3 )   S621 - S629   2018.12

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    A core-shell protein cluster comprising hemoglobin and human serum albumins, hemoglobin-albumin cluster (Hb-HSA3), was designed and synthesized for use as an artificial O2 carrier and red blood cell (RBC) substitute. For initial preclinical safety evaluation of the Hb-HSA3 solution, we observed blood compatibility in vitro, physiological responses after exchange transfusion into rats and blood circulation lifetime in dogs. Dilution of human whole blood with Hb-HSA3 showed an appropriate decrease in blood cell number, proportional to the mixing volume ratio. Time courses in the circulation parameters and blood gas parameters after 20% exchange transfusion with Hb-HSA3 in anesthetized rats were almost identical to those observed in a sham group (without infusion) and an HSA group (with HSA administration) for 6 h. Serum biochemical tests of the withdrawn blood indicated safety of the protein cluster. Furthermore, fluorescent Hb-HSA3 was infused into beagle dogs to assess blood retention. Fluorescence measurements of the blood samples enabled us to ascertain the cluster half-life within the intravascular space. Histopathologic inspections of the vital organs imply no abnormality in tissues. All these results indicate sufficient initial preclinical safety of Hb-HSA3 as an alternative material for use in RBC transfusion.

    DOI： 10.1080/21691401.2018.1505740

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  • Stratiform Protein Microtube Reactors Containing Glucose Oxidase Layer Reviewed

    R. Adachi, M. Akiyama, Y. Morita, T. Komatsu

    Chem. Asian J.   13 ( 19 )   2796 - 2799   2018.10

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  • ラット出血性ショックモデルを用いたHemoActの有効性評価

    鹿島 知周, 市原 聖人, 岡本 航, 小野沢 博登, 河野 光智, 岩崎 正之, 小松 晃之

    人工血液   26 ( 1 )   30 - 30   2018.10

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  • Bulky Iodotriazolium Tetrafluoroborates as Highly Active Halogen-Bonding-Donor Catalysts Reviewed

    R. Haraguchi, S. Hoshino, M. Sakai, S. Tanazawa, Y. Morita, T. Komatsu

    Chem. Commun.   54 ( 73 )   10320 - 10323   2018.9

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  • Transparent Protein Microtube Motors with Controllable Velocity and Biodegradability [Cover Image] Reviewed

    N. Sugai, Y. Nakai, Y. Morita, T. Komatsu

    ACS Appl. Nano Mater.   1 ( 7 )   3080 - 3085   2018.7

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  • A Novel Hemoglobin-Based Oxygen Carrier Bound with Albumin Shows Neuroprotection with Possible Antioxidant Effects Reviewed

    M. Gekka, T. Abumiya, T. Komatsu, R. Funaki, K. Kurisu, D. Shimbo, M. Kawabori, T. Osanai, N. Nakayama, K. Kazumata, K. Houkin

    Stroke   49 ( 8 )   1960 - 1968   2018.7

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  • Core-Shell Protein Clusters Comprising Haemoglobin and Recombinant Feline Serum Albumin as an Artificial O2 Carrier for Cats Reviewed

    K. Yokomaku, M. Akiyama, Y. Morita, K. Kihira, T. Komatsu

    J. Mater. Chem. B   6 ( 16 )   2417 - 2425   2018

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    DOI： 10.1039/c8tb00211h

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  • Self-Propelled Soft Protein Microtubes with a Pt Nanoparticle Interior Surface [Cover Image] Reviewed

    S. Kobayakawa, Y. Nakai, M. Akiyama, T. Komatsu

    Chem. Eur. J.   23 ( 21 )   5045 - 5050   2017.4

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  • Structural Insights into a Hemoglobin-Albumin Cluster in Aqueous Medium Reviewed

    R. Shinohara, T. Yamada, B. Schade, C. Boettcher, T. Sato, N. Sugimura, T. Shibue, T. Komatsu

    J. Phys. Chem. Lett.   8 ( 4 )   819 - 824   2017.2

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    DOI： 10.1021/acs.jpclett.6b02907

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  • Glycoprotein Nanotube Traps Influenza Virus Reviewed

    S. Yuge, M. Akiyama, M. Ishii, H. Namkoong, K. Yagi, Y. Nakai, R. Adachi, T. Komatsu

    Chem. Lett.   46 ( 1 )   95 - 98   2017.1

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    DOI： 10.1246/cl.160805

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  • Artificial Blood for Dogs Reviewed

    K. Yamada, K. Yokomaku, M. Kureishi, M. Akiyama, K. Kihira, T. Komatsu

    Sci. Rep.   6   36782,1 - 11   2016.11

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    DOI： 10.1038/srep36782

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  • Influence of Molecular Structure on O2-Binding Properties and Blood Circulation of Hemoglobin Albumin Clusters Reviewed

    K. Yamada, K. Yokomaku, R. Haruki, K. Taguchi, S. Nagao, T. Maruyama, M. Otagiri, T. Komatsu

    Plos ONE   11 ( 2 )   e0149526:1 - 15   2016.2

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    DOI： 10.1371/journal.pone.0149526

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  • Nanotube Reactor with a Lipase Wall Interior for Enzymatic Ring-opening Oligomerization of Lactone Reviewed

    Y. Amano, T. Komatsu

    Chem. Lett.   44 ( 12 )   1646 - 1648   2015.12

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    DOI： 10.1246/cl.150789

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  • Highly Sensitive Detection of Organophosphorus Pesticides Using 5,10,15,20-Tetrakis(4-hydroxyphenyl)porphyrin Reviewed

    T. Murakami, Y. Iwamuro, S. Chinaka, N. Takayama, T. Komatsu

    Anal. Sci.   31 ( 12 )   1325 - 1328   2015.12

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  • Core-shell Clusters of Human Haemoglobin A and Human Serum Albumin: Artificial O2-Carriers Having Various O2-Affinities Reviewed

    T. Kimura, R. Shinohara, C. Boettcher, T. Komatsu

    J. Mater. Chem. B   3 ( 30 )   6157 - 6164   2015.8

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    DOI： 10.1039/c5tb00540j

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  • Safety Evaluation of Hemoglobin-Albumin Cluster "HemoAct" as a Red Blood Cell Substitute Reviewed

    Risa Haruki, Takuya Kimura, Hitomi Iwasaki, Kana Yamada, Ikuo Kamiyama, Mitsutomo Kohno, Kazuaki Taguchi, Saori Nagao, Toru Maruyama, Masaki Otagiri, Teruyuki Komatsu

    SCIENTIFIC REPORTS   5   12778:1 - 9   2015.7

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    DOI： 10.1038/srep12778

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  • Haemoglobin Wrapped Covalently by Human Serum Albumin Mutants Containing Mn(III) Protoporphyrin IX: an O2 Complex Stable in H2O2 Solution [Cover Image] Reviewed

    Y. Daijima, T. Komatsu

    Chem. Commun.   50 ( 94 )   14716 - 14719   2014.12

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    DOI： 10.1039/c4cc06076h

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  • Cross-Linked Human Serum Albumin Dimer has the Potential for Use as a Plasma-Retaining Agent for the Fatty Acid-Conjugated Antidiabetic Drugs Reviewed

    K. Taguchi, V. Chuang, K. Yamasaki, Y. Urata, R. Tanaka, M. Anraku, H. Seo, K. Kawai, T. Maruyama, T. Komatsu, M. Otagiri

    J. Pharm. Phamacol.   67 ( 2 )   255 - 263   2014.12

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  • Size-Dependent Dextran Loading in Protein Nanotube with an Interior Wall of Concanavalin A Reviewed

    Y. Shiraishi, M. Akiyama, T. Sato, M. Hattori, T. Komatsu

    Polym. Adv. Technol.   25 ( 11 )   1247 - 1251   2014.11

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    DOI： 10.1002/pat.3299

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  • Hemoglobin‒Albumin Cluster Incorporating a Pt Nanoparticle: Artificial O2 Carrier with Antioxidant Activities Reviewed

    Hitomi Hosaka, Risa Haruki, Kana Yamada, Christoph Boettcher, Teruyuki Komatsu

    PLOS ONE   9 ( 10 )   e110541:1 - 9   2014.10

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    DOI： 10.1371/journal.pone.0110541

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  • An Escherichia coli Trap in Human Serum Albumin Microtubes [Cover Image] Reviewed

    S. Yuge, M. Akiyama, T. Komatsu

    Chem. Commun.   50 ( 68 )   9640 - 9643   2014.9

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    DOI： 10.1039/c4cc03632h

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  • Artificial Oxygen Carrier Invited Reviewed

    T. Komatsu

    Chemistry and Industires   67 ( 8 )   677 - 679   2014.8

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  • Fluorescent Dimer and Fiber of meso-Tetrakis{o-(isonicotinoylamino)phenyl}porphyrin Connected by Pd(II) Coordinations Reviewed

    S. Kasuya, Y. Yamazawa, N. Sugimura, T. Shibue, T. Komatsu

    Chem. Lett.   43 ( 7 )   1008 - 1010   2014.7

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    DOI： 10.1246/cl.140243

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  • Superoxide Dismutase Activity of the Naturally Occurring Human Serum Albumin‒Copper Complex without Hydroxyl Radical Formation Reviewed

    R. Kato, M. Akiyama, H. Kawakami, T. Komatsu

    Chem. Asian J.   9 ( 1 )   83 - 86   2014.1

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  • Human Serum Albumin Mutants Complexed Mn(III) Protoporphyrin IX as Superoxide Dismutase Mimics Reviewed

    R. Kato, Y. Kobayashi, M. Akiyama, T. Komatsu

    Dalton Trans.   42 ( 45 )   15889 - 15892   2013.12

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    DOI： 10.1039/c3dt51418h

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  • Gold Nanoparticle Inclusion into Protein Nanotube as a Layered Wall Component Reviewed

    S. Goto, Y. Amano, M. Akiyama, C. Boettcher, T. Komatsu

    Langmuir   29 ( 46 )   14293 - 14300   2013.11

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    DOI： 10.1021/la403283x

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  • Covalent Core-Shell Architecture of Hemoglobin and Human Serum Albumin as an Artificial O2 Carrier Reviewed

    D. Tomita, T. Kimura, H. Hosaka, Y. Daijima, R. Haruki, K. Ludwig, C. Boettcher, T. Komatsu

    Biomacromolecules   14 ( 6 )   1816 - 1825   2013.6

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    DOI： 10.1021/bm400204y

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  • Structure and Photocatalytic Activity of Iron Oxide Nanotubes Prepared from Ferritin Reviewed

    R. Kato, T. Komatsu

    J. Inorg. Organometal. Polym. Mater.   23 ( 1 )   167 - 171   2013

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    DOI： 10.1007/s10904-012-9725-5

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  • Human Serum Albumin-Based Peroxidase Having an Iron-Protoporphyrin IX in Artificial Hemepocket Reviewed

    K. Watanabe, N. Ishikawa, T. Komatsu

    Chem. Asian J.   7   2534 - 2537   2012.8

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  • Human Serum Albumin Nanotubes with Esterase Activity Reviewed

    T. Komatsu, T. Sato, C. Böttcher

    Chem. Asian J.   7 ( 1 )   201 - 206   2012.1

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  • Protein–Protein Interactions in Solution and Their Interplay with Protein Specific Functions

    Sato Takaaki, Fukasawa Toshiko, Shimozawa Togo, Komatsu Teruyuki, Sakai Hiromi, Ishiwata Shin'ichi

    Journal of the Physical Society of Japan   81   2012

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    DOI： 10.1143/JPSJS.81SA.SA002

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  • Protein-based nanotubes for biomedical applications [Review] Invited Reviewed

    Teruyuki Komatsu

    Nanoscale   4 ( 6 )   1910 - 1918   2012

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    DOI： 10.1039/c1nr11224d

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  • Protein Nanotube Arrays Immobilized on Solid Substrates: Molecular Trap in Aqueous Medium Reviewed

    R. Kato, T. Komatsu

    Chem. Lett.   40 ( 12 )   1338 - 1339   2011.12

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    DOI： 10.1246/cl.2011.1338

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  • Protein Nanotubes Bearing a Magnetite Surface Exterior Reviewed

    T. Komatsu, N. Kobayashi

    Polym. Adv. Technol.   22 ( 8 )   1315 - 1318   2011.8

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    DOI： 10.1002/pat.1921

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  • Virus Trap in Human Serum Albumin Nanotube Reviewed

    T. Komatsu, X. Qu, H. Ihara, M. Fujihara, H. Azuma, H. Ikeda

    J. Am. Chem. Soc.   133 ( 10 )   3246 - 3248   2011.3

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    DOI： 10.1021/ja1096122

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  • Protein Nanotubes with an Enzyme Interior Surface Reviewed

    T. Komatsu, H. Terada, N. Kobayashi

    Chem. Eur. J.   17 ( 6 )   1849 - 1854   2011

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    DOI： 10.1002/chem.201001937

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  • Superior Plasma Retention of a Cross-Linked Human Serum Albumin Dimer in Nephrotic Rats as a New Type of Plasma Expander Reviewed

    K. Taguchi, Y. Urata, M. Anraku, H. Watanabe, K. Kawai, T. Komatsu, E. Tsuchida, T. Maruyama, M. Otagiri

    Drug Metab. Dispos.   38 ( 12 )   2124 - 2129   2010.12

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    DOI： 10.1124/dmd.109.031989

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  • Molecular Insight into Intrinsic Heme Distortion in Ligand Binding in Hemoprotein Reviewed

    S. Neya, M. Suzuki, T. Hoshino, H. Ode, K. Imai, T. Komatsu, A. Ikezaki, M. Nakamura, Y. Furutani, H. Kandori

    Biochemistry   49 ( 27 )   5642 - 5650   2010.7

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    DOI： 10.1021/bi1003553

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  • Solid Nanotubes Comprising alpha-Fe2O3 Nanoparticles Prepared from Ferritin Protein Reviewed

    Xue Qu, Nao Kobayashi, Teruyuki Komatsu

    ACS NANO   4 ( 3 )   1732 - 1738   2010.3

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    DOI： 10.1021/nn901879d

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  • Molecular Capture in Protein Nanotubes Reviewed

    X. Qu, T. Komatsu

    ACS Nano   4 ( 1 )   563 - 573   2010.1

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    DOI： 10.1021/nn901474y

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  • 臨床応用可能な酸素輸液の研究開発.

    酒井宏水, 小松晃之, 土田英俊, 西出宏之

    日経BPムック早稲田大学連携レビュー   52-53   2010

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  • The Role of an Amino Acid Triad at the Entrance of the Heme Pocket in Human Serum Albumin for O2 and CO binding to iron protoporphyrin IX Reviewed

    T. Komatsu, A. Nakagawa, S. Curry, E. Tsuchida, K. Murata, N. Nakamura, H. Ohno

    Org. Biomol. Chem.   7 ( 18 )   3836 - 3841   2009.9

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    DOI： 10.1039/b909794e

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  • Artificial Oxygen Carriers, Hemoglobin Vesicles and Albumin-Hemes, Based on Bioconjugate Chemistry (Review) Reviewed

    E. Tsuchida, K. Sou, A. Nakagawa, H. Sakai, T. Komatsu, K. Kobayashi

    Bioconjugate Chem.   20 ( 8 )   1419 - 1440   2009.8

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    DOI： 10.1021/bc800431d

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  • Structural and Mutagenic Approach to Create Human Serum Albumin-Based Oxygen Carrier and Photosensitizer (Review) Reviewed

    T. Komatsu, A. Nakagawa, X. Qu

    Drug Metab. Pharmacokinet.   24 ( 4 )   287 - 299   2009.8

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  • ヒト血清アルブミンを用いた機能分子・材料の創製（総説） Reviewed

    小松晃之, 屈 幸, 土田英俊, 中川晶人

    人工血液   17 ( 2 )   82 - 89   2009.8

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  • O2 Binding Properties of Human Serum Albumin Quadruple Mutant Complexed Iron Protoporphyrin IX with Axial His-186 Coordination Reviewed

    A. Nakagawa, T. Komatsu, S. Curry, E. Tsuchida

    Chem. Lett.   38 ( 8 )   776 - 777   2009.8

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    DOI： 10.1246/cl.2009.776

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  • Structure, Photophysical Property, and Cytotoxicity of Human Serum Albumin Complexed with Tris(dicarboxymethylene)[60]fullerene Reviewed

    X. Qu, T. Komatsu, T. Sato, O. Glatter, H. Horinouchi, K. Kobayashi, E. Tuchida

    Bioconjugate Chem.   19 ( 8 )   1556 - 1560   2008.11

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    DOI： 10.1021/bc800207j

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  • Protein Nanotubes Comparised of an Alternate Layer-by-Layer Assembly Using a Polycation as an Electrostatic Glue Reviewed

    X. Qu, G. Lu, E. Tsuchida, T. Komatsu

    Chem. Eur. J.   14 ( 33 )   10303 - 10308   2008.11

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    DOI： 10.1002/chem.200800771

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  • Functional Evaluation of Iron Oxypyriporphyrin in Protein Heme Pocket Reviewed

    S. Neya, M. Suzuki, H. Ode, T. Hoshino, Y. Furutani, H. Kandori, H. Hori, K. Imai, T. Komatsu

    Inorg. Chem.   47 ( 22 )   10771 - 10778   2008.11

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    DOI： 10.1021/ic801406x

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  • Human Serum Albumin Nanotubes Comprising Layer-by-layer Assembly with Polycation Reviewed

    G. Lu, E. Tsuchida, T. Komatsu

    Chem. Lett.   37 ( 9 )   972 - 973   2008.9

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    DOI： 10.1246/cl.2008.972

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  • Heme Pocket Architecture in Human Serum Albumin: Regulation of O2 Binding Affinity of a Prosthetic Heme Group by Site-Directed Mutagenesis Reviewed

    T. Komatsu, A. Nakagawa, E. Tsuchida

    Macromol. Symp.   270 ( 1 )   187 - 192   2008.8

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  • Enhanced radiation response of a solid tumor with the artificial oxygen carrier &apos;albumin-heme&apos; Reviewed

    H. Horinouchi, H. Yamamoto, T. Komatsu, Y. Huang, E. Tsuchida, K. Kobayashi

    Cancer Sci.   99 ( 6 )   1274 - 1278   2008.6

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    DOI： 10.1111/j.1349-7006.2008.00811.x

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  • O2 Binding to Human Serum Albumin Incorporating Iron Porphyrin with a Covalently Linked Methyl-L-Histidine Isomer Reviewed

    A. Nakagawa, T. Komatsu, M. Iizuka, E. Tsuchida

    Bioconjugate Chem.   19 ( 3 )   581 - 584   2008.3

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    DOI： 10.1021/bc700400n

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  • O2-Binding Albumin Thin Films: Solid Membranes of Poly(ethylene glycol)-Conjugated Human Serum Albumin Incorporating Iron Porphyrin Reviewed

    A. Nakagawa, T. Komatsu, Y. Huang, G. Lu, E. Tsuchida

    Bioconjugate Chem.   18 ( 5 )   1673 - 1677   2007.9

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    DOI： 10.1021/bc070086m

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  • Genetic Engineering of the Heme Pocket in Human Serum Albumin: Modulation of O2 Binding of Iron Protoporphyrin IX by Variation of Distal Amino Acids Reviewed

    T. Komatsu, A. Nakagawa, P. A. Zunszain, S. Curry, E. Tsuchida

    J. Am. Chem. Soc.   129 ( 36 )   11286 - 11295   2007.9

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    DOI： 10.1021/ja074179q

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  • Artificial Hemoprotein Nanotubes Reviewed

    G. Lu, T. Komatsu, E. Tsuchida

    Chem. Commun.   ( 28 )   2980 - 2982   2007.7

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    DOI： 10.1039/b704135g

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  • Influence of O2-Carrying Plasma Hemoprotein “Albumin-Heme” on Complement System and Platelet Activation in vitro and Physiological Responses to Exchange Transfusion Reviewed

    T. Komatsu, Y. Huang, S. Wakamoto, H.Abe, M. Fujihara, H. Azuma, H. Ikeda, H.Yamamoto, H. Horinouchi, K. Kobayash, E. Tsuchida

    JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A   81A ( 4 )   821 - 826   2007.6

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    DOI： 10.1002/jbm.a.31016

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  • meso-Tetrakis(α,α,α,α-o-amidophenyl)porphinatoiron(II) Bearing a Proximal Histidyl Group at the β-pyrrolic Position via an Acyl Bond: Synthesis and O2 Coordination in Aqueous Media Reviewed

    A. Nakagawa, T. Komatsu, E. Tsuchida

    Chem. Lett.   36 ( 5 )   640 - 641   2007.5

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  • Induced Long-Range Attractive Potentials of Human Serum Albumin by Ligand Binding Reviewed

    T. Sato, T. Komatsu, A. Nakagawa, E. Tsuchida

    Phys. Rev. Lett.   98 ( 20 )   208101-1 - 4   2007.5

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    DOI： 10.1103/PhysRevLett.98.208101

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  • Photosensitized Reduction of Water to Hydrogen using Human Serum Albumin Complexed with Zinc-Protoporphyrin IX Reviewed

    T. Komatsu, R.-M. Wang, P. A. Zunszain, S. Curry, E. Tsuchida

    J. Am. Chem. Soc.   128 ( 50 )   16297 - 16301   2006.12

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    DOI： 10.1021/ja0656806

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  • ポリ（エチレングリコール）修飾アルブミン－ヘム：酸素輸送血漿増量剤としての溶液物性と機能（総説） Reviewed

    小松晃之

    人工血液   14 ( 2 )   47 - 54   2006.9

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  • PEGylated Albumin-Heme as an Oxygen-Carrying Plasma Expander: Exchange Transfusion into Acute Anemia Rat Model Reviewed

    Y. Huang, T. Komatsu, H. Yamamoto, H. Horinouchi, K. Kobayashi, E. Tsuchida

    Biomaterials   27 ( 25 )   4477 - 4483   2006.9

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    DOI： 10.1016/j.biomaterials.2006.04.008

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  • Poly(ethylene glycol)-Conjugated Human Serum Albumin Including Iron Porphyrins: Surface Modification Improves the O2-Transporting Ability Reviewed

    Y. Huang, T. Komatsu, R.-M. Wang, A. Nakagawa, E. Tsuchida

    Bioconjugate Chem.   17 ( 2 )   393 - 398   2006.3

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    DOI： 10.1021/bc050315+

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  • Human serum albumin hybrid incorporating tailed porphyrinatoiron(II) in the alpha,alpha,alpha,beta-conformer as an O-2-binding site Reviewed

    A Nakagawa, T Komatsu, M Iizuka, E Tsuchida

    BIOCONJUGATE CHEMISTRY   17 ( 1 )   146 - 151   2006.1

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    DOI： 10.1021/bc050154+

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  • O2-binding properties of albumin hybrid incorporating porphyrinatoiron having histidine derivative

    Akito Nakagawa, Teruyuki Komatsu, Eishun Tsuchida, Makoto Iiduka, Shinji Takeoka

    Polymer Preprints, Japan   55 ( 2 )   4921   2006

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  • Albumin-heme. A synthetic heme-based oxygen carrier

    Teruyuki Komatsu, Yubin Huang, Hisashi Yamamoto, Hirohisa Horinouchi, Koichi Kobayashi, Eishun Tsuchida

    Blood Substitutes   532 - 539   2006

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    DOI： 10.1016/B978-012759760-7/50057-3

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  • Relationship between structure of heme pocket and oxygen-binding ability of recombinant albumin-protoheme

    Teruyuki Komatsu, Akito Nakagawa, Eishun Tsuchida

    Polymer Preprints, Japan   55 ( 1 )   1894   2006

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  • O2 and CO Binding Properties of Artificial Hemoproteins Formed by Complexing Iron Protoporphyrin IX with Human Serum Albumin Mutants Reviewed

    T. Komatsu, N. Ohmichi, A. Nakagawa, P. A. Zunszain, S. Curry, E. Tsuchida

    J. Am. Chem. Soc.   127 ( 45 )   15933 - 15942   2005.11

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    DOI： 10.1021/ja054819u

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  • Albumin Clusters: Structurally Defined Protein Tetramer and Oxygen Carrier Including Thirty-Two Iron(II) Porphyrins Reviewed

    T. Komatsu, Y. Oguro, A. Nakagawa, E. Tsuchida

    Biomacromolecules   6 ( 6 )   3397 - 3403   2005.11

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    DOI： 10.1021/bm050454u

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  • Heat-Resistant Oxygen-Carrying Hemoproteins Consist of Recombinant Xylanases and Synthetic Iron(II) Porphyrin Reviewed

    T. Komatsu, S. Ishihara, E. Tsuchida, H. Nishide, C. Morokuma, S. Nakamura

    Biomacromolecules   6 ( 3 )   1489 - 1494   2005.5

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    DOI： 10.1021/bm0492551

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  • Preparation of Co-Na Heterobinuclear Polymeric Complex of Salen-Crown Ether and Its Catalytic Activation for Molecular Oxygen Reviewed

    R.-M. Wang, Z. F. Duan, Y. F. He, B. Y Yang, Y. P. Wang, T. Komatsu, E. Tsuchida

    J. Macromol. Sci. A. Pure Appl. Chem.   A42 ( 2 )   231 - 235   2005.2

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    DOI： 10.1081/MA-200046986

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  • Oxygen Infusions (Hemoglobin-Vesicles and Albumin-Hemes) Based on Nono-Molecular Sciences (Review) Reviewed

    E. Tsuchida, H. Sakai, T. Komatsu, S. Takeoka, Y. Huang, K. Sou, A. Nakagawa, Y. Teramura, K. Kobayashi

    Polym. Adv. Technol.   16 ( 2,3 )   1 - 11   2005.2

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  • Oxygen infusions (hemoglobin-vesicles and albumin-hemes) based on nano-molecular sciences

    Eishun Tsuchida, Hiromi Sakai, Teruyuki Komatsu, Shinji Takeoka, Yubin Huang, Keitaro Sou, Akito Nakagawa, Yuji Teramura, Koichi Kobayashi

    Polymers for Advanced Technologies   16 ( 2-3 )   73 - 83   2005.2

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    DOI： 10.1002/pat.559

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  • Human Serum Albumin Bearing Covalently Attached Iron(II) Porphyrins as O2-coordination sites Reviewed

    R.-M. Wang, T. Komatsu, A. Nakagawa, E. Tsuchida

    Bioconjugate Chem.   16 ( 1 )   23 - 26   2005.1

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    DOI： 10.1021/bc049859m

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  • Oxygen-Carrying Plasma Hemoprotein Including Synthetic Heme Reviewed

    T Komatsu, E Tsuchida

    ARTIFICIAL OXYGEN CARRIER: ITS FRONT LINE   12   193 - 204   2005

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  • O2-binding properties of recombinant albumin-protoheme hybrid

    Akito Nakagawa, Teruyuki Komatsu, Eishun Tsuchida

    Polymer Preprints, Japan   54 ( 2 )   4074   2005

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  • Exchange transfusion with synthetic oxygen-carrying plasma protein "albumin-heme" into an acute anemia rat model after seventy-percent hemodilution Reviewed

    T. Komatsu, H. Yamamoto, Y. Huang, H. Horinouchi, K. Kobayashi, E. Tsuchida

    J. Biomed. Mater. Res.   71A ( 4 )   644 - 651   2004.12

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    DOI： 10.1002/jbm.a.30200

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  • Safety Evaluation of an Artificial O2 Carrier as a Red Blood Cell Substitute by Blood Biochemical Tests and Histopathology Observations Reviewed

    Y. Huang, T. Komatsu, H. Yamamoto, H. Horinouchi, K. Kobayashi, E. Tsuchida

    ASAIO J.   50 ( 6 )   525 - 529   2004.11

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    DOI： 10.1097/01.MAT.0000144361.60280.DA

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  • Physicochemical Characterization of Cross-Linked Human Serum Albumin Dimer and Its Synthetic Heme Hybrid as an Oxygen Carrier Reviewed International journal

    T. Komatsu, Y. Oguro, Y. Teramura, S. Takeoka, J. Okai, M. Anraku, M. Otagiri, E. Tsuchida

    Biochim. Biophys. Acta   1675 ( 1-3 )   21 - 31   2004.11

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    DOI： 10.1016/j.bbagen.2004.08.010

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  • Dioxygenation of Human Serum Albumin Having a Prosthetic Heme Group in a Tailor-Made Heme Pocket Reviewed

    T. Komatsu, N. Ohmichi, P. A. Zunszain, S. Curry, E. Tsuchida

    J. Am. Chem. Soc.   126 ( 44 )   14304 - 14305   2004.11

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    DOI： 10.1021/ja046022t

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  • Exchange Transfusion with Entirely Synthetic Red-Cell Substitute Albumin-Heme into Rats: Physiological Responses and Blood Biochemical Tests Reviewed

    Y. Huang, T. Komatsu, H. Yamamoto, H. Horinouchi, K. Kobayashi, E. Tsuchida

    J. Biomed. Mater. Res.   71A ( 1 )   63 - 69   2004.10

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  • 酸素輸送合成へム蛋白質“アルブミン－ヘム”の創製と酸素輸液の展開

    小松晃之, 土田英俊

    体液・代謝管理   20 ( 1 )   3 - 6   2004.4

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  • Synthesis of Protoheme IX Derivatives with a Covalently Linked Proximal Base and Their Human Serum Albumin Hybrids as Artificial Hemoprotein Reviewed

    A. Nakagawa, N. Ohmichi, T. Komatsu, E. Tsuchida

    Org. Biomol. Chem.   2 ( 21 )   3108 - 3112   2004

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    DOI： 10.1039/b409017a

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  • テトラ（シクロヘキサノイル基）を有するヘムを包接したヒト血清アルブミン-ヘム複合体の酸素結合反応 Reviewed

    小松晃之, 石原星児, 土田英俊

    人工血液   11 ( 3 )   167 - 172   2003.11

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  • Oxygen-Carrying Plasma Hemoprotein “Albumin-Heme”: Nitric Oxide Binding and Physiological Responses after Administration in vivo Reviewed

    E. Tsuchida, T. Komatsu

    Macomol. Symp.   204   13 - 18   2003.11

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  • Molecular Energy and Electron Transfer Assemblies Made of Self-Organized Lipid-Porphyrin Bilayer Vesicles Reviewed

    T. Komatsu, M. Moritake, E Tsuchida

    Chem. Eur. J.   9 ( 19 )   4626 - 4633   2003.10

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    DOI： 10.1002/chem.200305013

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  • Microcalorimetry Investigation of Synthetic Hemoprotein (Albumin-Heme) Reviewed

    Y. Huang, T. Komatsu, E. Tsuchida

    Polym. Adv. Technol.   14 ( 10 )   729 - 732   2003.10

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    DOI： 10.1002/pat.418

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  • 代謝系人工臓器・人工酸素運搬体のニューテクノロジー 人工赤血球 その機能,生体反応,安全性について

    堀之内 宏久, 小林 紘一, 渡辺 真純, 泉 陽太郎, 山内 徳子, 山本 学, 末松 誠, 武岡 真司, 酒井 宏水, 小松 晃之, 土田 英俊

    人工臓器   32 ( 2 )   S22 - S22   2003.9

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  • Compatibility in vitro of Albumin-Heme (O2 Carrier) with Blood Cell Components Reviewed

    Y. Huang, T. Komatsu, A. Nakagawa, E. Tsuchida, S. Kobayashi

    J. Biomed. Mater. Res.   66A ( 2 )   292 - 297   2003.8

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    DOI： 10.1002/jbm.a.10573

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  • Crystal Structural Analysis of Human Serum Albumin Complexed with Hemin and Fatty Acid Reviewed

    P. A. Zunszain, J. Ghuman, T. Komatsu, E. Tsuchida, S. Curry

    BMC Struct. Biol.   3   1 - 9   2003.7

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    DOI： 10.1186/1472-6807-3-1

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  • Synthetic Dioxygen-Carrying Hemoprotein. Human Serum Albumin Including Iron(II) Complex of Protoporphyrin IX with an Axially Coordinated Histidylglycyl-Propionate Reviewed

    A. Nakagawa, T. Komatsu, N. Ohmichi, E. Tsuchida

    Chem. Lett.   32 ( 6 )   504 - 505   2003.6

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  • Human Serum Albumin Incorporating Synthetic Heme: Red Blood Cell Substitute without Hypertension by Nitric Oxide Scavenging Reviewed

    E. Tsuchida, T. Komatsu, Y. Matsukawa, A. Nakagawa, H. Sakai, K. Kobayashi, M. Suematsu

    J. Biomed. Mater. Res.   64A ( 2 )   257 - 261   2003.2

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  • meso-Tetrakis[o-(N-methyl)pyridinium]porphyrin Ensembles with Axially Coordinated Cyclodextrin-Penetrating Phenethylimidazole: Reversible Dioxygen-Binding in Aqueous DMF Solution Reviewed

    T. Komatsu, S. Hayakawa, E. Tsuchida, H. Nishide

    Chem. Commun.   ( 1 )   50 - 51   2003.1

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    DOI： 10.1039/b208882g

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  • Coordination Structure of Active Site in Synthetic Hemoprotein (Albumin-Heme) with Dioxygen and Carbon Monoxide Reviewed

    E. Tsuchida, A. Nakagawa, T. Komatsu

    Macromol. Symp.   195   275 - 280   2003.1

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  • Thermostable Synthetic Hemoproteins: Thermophilic Xylanases Hybridized with Dioxygen-Carrying meso-Tetrakis(o-pivalamidophenyl)porphinatoiron(II) Derivative Reviewed

    T. Komatsu, S. Ishihara, E. Tsuchida, H. Nishide, C. Morokuma, S. Nakamura

    Chem. Lett.   32 ( 1 )   108 - 109   2003.1

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  • Oxygenation of Hypoxic Region in Solid Tumor by Administration of Human Serum Albumin Incorporating Synthetic Hemes Reviewed

    K. Kobayashi, T. Komatsu, A. Iwamaru, Y. Matsukawa, M. Watanabe, H. Horinouchi, E. Tsuchida

    J. Biomed. Mater. Res.   64A ( 1 )   48 - 51   2003.1

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  • Safety of artificial oxygen carrier (synthetic erythrocytes) and the ability to supply oxygen to tissues

    E. Tsuchida, K. Sou, H. Sakai, T. Komatsu, S. Takeoka, H. Horinouchi, M. Suematsu, K. Kobayashi

    Masui   53(Suppl.)   S55-66   2003

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  • Self-Organized Lipid-Porphyrin Bilayer Membranes in Vesicular Form: Nanostructure, Photophysical Properties, and Dioxygen Coordination Reviewed

    T Komatsu, W Moritake, A Nakagawa, E Tsuchida

    CHEMISTRY-A EUROPEAN JOURNAL   8 ( 23 )   5469 - 5480   2002.12

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  • 自己組織化リピドヘム小胞体のナノ構造と酸素結合能 Reviewed

    小松晃之, 森武美保, 土田英俊

    人工血液   10 ( 4 )   120 - 125   2002.12

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  • Preservation Stability and in vivo Administration of Albumin-Heme Hybrid Solution as an Entirely Synthetic O2-Carrier Reviewed

    E Tsuchida, T Komatsu, T Yanagimoto, H Sakai

    POLYMERS FOR ADVANCED TECHNOLOGIES   13 ( 10-12 )   845 - 850   2002.10

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    DOI： 10.1002/pat.240

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  • Human Serum Albumin Incorporating Synthetic Hemes as an O2-Carrying Hemoprotein: Control of O2-Binding Ability by Heme Structure Reviewed

    E Tsuchida, T Komatsu, Y Mastukawa, T Okada

    Macromol. Symp.   186   1 - 6   2002.8

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  • Effect of Heme Structure on O2-Binding Properties of Human Serum Albumin-Heme Hybrids: Intramolecular Histidine Coordination Provides a Stable O2-Adduct Complex Reviewed

    T Komatsu, Y Matsukawa, E Tsuchida

    Bioconhugate Chem.   13 ( 3 )   397 - 402   2002.5

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    DOI： 10.1021/bc010067r

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  • Photoreduction of a Self-Assembled (Lipidporphyrinato)iron(III) Complex in Saline by LMCT Excitation: Co-Aggregated Hyaluronic Acid Allows an Irreversible Electron Transfer Reviewed

    T Yanagimoto, A Nakagawa, T Komatsu, E Tsuchida

    Bull. Chem. Soc. Jpn   74 ( 11 )   2123 - 2128   2001.11

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  • Electrochemical Studies of Albumin-Heme Hybrid in Aqueous Media by Modified Electrode Reviewed

    Y. Wu, T. Komatsu, E. Tsuchida

    Inorg. Chem. Acta   322 ( 1-2 )   120 - 124   2001.10

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  • O2-Binding Properties of Double-Sided Porphinatoiron(II)s with Polar Substituents and Their Human Serum Albumin Hybrids Reviewed

    T. Komatsu, T. Okada, M. Moritake, E. Tsuchida

    Bull. Chem. Soc. Jpn   74 ( 9 )   1695 - 1702   2001.9

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  • Iron(II) Complex of Octopus-Porphyrin with a Covalently Linked Proximal Imidazole; Self-Assembly and O2-Coordination in Aqueous Media Reviewed

    T. Komatsu, S. Hayakawa, T. Yanagimoto, M. Kobayakawa, A. Nakagawa, E. Tsuchida

    Bull. Chem. Soc. Jpn   74 ( 9 )   1703 - 1707   2001.9

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  • O-2-adduct complex of meso-tetrakis(alpha,alpha,alpha,alpha-o-pivalamidophenyl)porphinatoiron(II) with an intramolecularly coordinated proximal histidine Reviewed

    T Komatsu, Y Matsukawa, K Miyatake, E Tsuchida

    Chem. Lett.   30 ( 7 )   668 - 669   2001.7

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  • Photoreduction of Autooxidized Albumin-Heme Hybrid in Saline Solution: Revival of Its O2-Binding Ability Reviewed

    A Nakagawa, T Komatsu, E Tsuchida

    Bioconjugate Chem.   12 ( 4 )   648 - 652   2001.7

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  • Reaction of Nitric Oxide with Synthetic Hemoprotein, Human Serum Albumin Incorporating Tetraphenylporphinatoiron(II) Derivatives Reviewed

    T. Komatsu, Y. Matsukawa, E. Tsuchida

    Bioconjugate Chem.   12 ( 1 )   71 - 75   2001.1

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    DOI： 10.1021/bc000067b

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  • 人工赤血球（人工酸素運搬体）－酸素輸液（人工赤血球）の設計原理とその具体的構造－

    土田英俊, 小松晃之, 酒井宏水

    血液、免疫、腫瘍   6 ( 4 )   12 - 18   2001.1

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  • Kinetics of CO and O2 Binding to Human Serum Albumin-Heme Hybrid Reviewed

    T. Komatsu, Y. Matsukawa, E. Tsuchida

    Bioconjugate Chem.   11 ( 6 )   772 - 776   2000.11

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  • Redox behavior of human serum albumin-heme hybrid on graphite electrode modified with didodecyldimethylammonium bromide Reviewed

    YP Wu, T Komatsu, E Tsuchida

    CHEMISTRY LETTERS   29 ( 10 )   1194 - 1195   2000.10

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  • Nitrosyl iron(II) complex of meso-tetrakis(alpha,alpha,alpha,alpha-o-pivalamidophenyl)porphyrin with a covalently linked 2-methylimidazolylalkyl group Reviewed

    T Komatsu, Y Matsukawa, E Tsuchida

    CHEMISTRY LETTERS   29 ( 9 )   1060 - 1061   2000.9

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  • Photoinduced Electron Transfer Between Lipidporphyrinato-zinc(II) and -iron(III) Complexes in a Phospholipid Vesicular Membrane Reviewed

    T. Yanagimoto, T. Komatsu, E. Tsuchida

    Inorg. Chim. Acta   305 ( 1 )   26 - 31   2000.7

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  • Exchange Transfusion with Albumin-Heme as an Artificial O2-Infusion into Anesthetized Rats: Physiological Responses, O2-Delivery, and Reduction of the Oxidized Hemin Sites by Red Blood Cells Reviewed

    E. Tsuchida, T. Komatsu, K. Hamamatsu, Y. Matsukawa, A. Tajima, A. Yoshizu, Y. Izumi, K. Kobayashi

    Bioconjugate Chem.   11 ( 1 )   46 - 50   2000.1

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  • Molecular Environment Effect on O2 Binding to Lipidporphyrinatoiron(II) Complexes in Aqueous Media Reviewed

    E. Tsuchida, T. Komatsu, T. Yanagimoto

    J. Porhyr. Phthalocyanines   4 ( 1 )   81 - 87   2000.1

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  • Photoreduction of Self-Assembled Lipidporphyrinato-iron(III) Chloride with Hyaluronic Acid under Semi-Physiological Conditions Reviewed

    T. Komatsu, T. Yanagimoto, A. Nakagawa, E. Tsuchida

    Chem. Lett.   29 ( 1 )   84 - 85   2000.1

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  • Cross-Linked Human Serum Albumin Dimer Incorporating Sixteen (Tetraphenylporphinato)iron(II) Derivatives: Synthesis, Characterization, and O2-Binding Property Reviewed

    T. Komatsu, K. Hamamatsu, E. Tsuchida

    Macromolecules   32 ( 25 )   8388 - 8391   1999.12

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  • 5,10,15,20-Tetrakis(alpha,alpha,alpha,alpha-o-pivalamidophenyl)porphinatoiron(II) bearing a covalently linked axial imidazole via m-aminobenzoic acid. Synthesis and influence of imidazole basicity on O-2-binding affinity Reviewed

    T Komatsu, Y Furubayashi, H Nishide, E Tsuchida

    Inorg. Chim. Acta   295 ( 2 )   234 - 238   1999.11

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  • Human Serum Albumin Incorporating Tetrakis(o-pivalamido)phenylporphinatoiron(II) Derivative as a Totally Synthetic O2-Carrying Hemoprotein Reviewed

    E. Tsuchida, T. Komatsu, Y. Matsukawa, K. Hamamatsu, J. Wu

    Bioconjugate Chem.   10 ( 5 )   797 - 802   1999.9

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  • Self-Assembled Fibers made of Lipidporphyrinato-zinc(II) and -iron(II) Complexes with an Intramolecular Coordinated Axial Imidazole Reviewed

    T. Komatsu, T. Yanagimoto, Y. Furubayashi, J. Wu, E. Tsuchida

    Langmuir   15 ( 13 )   4427 - 4433   1999.6

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  • Lipidheme vesicles and hemoglobin vesicles as dioxygen infusion

    Teruyuki Komatsu, Shinji Takeoka, Hiromi Sakai, Eishun Tsuchida

    American Chemical Society, Polymer Preprints, Division of Polymer Chemistry   40 ( 1 )   365   1999.3

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  • Human serum albumin-heme hybrid as dioxygen infusion

    Teruyuki Komatsu, Eishun Tsuchida

    American Chemical Society, Polymer Preprints, Division of Polymer Chemistry   40 ( 1 )   366 - 367   1999.3

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  • Photoexcitation and Electron Transfer Reactions of Zinc Lipidporphyrins in DMSO Reviewed

    T. Ohgushi, Z.-C. Li, F.-M. Li, T. Komatsu, S. Takeoka, E. Tsuchida

    J. Porphyr. Phthalocyanines   3 ( 1 )   53 - 59   1999.1

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  • Physicochemical Properties and O2-Coordination Structure of Human Serum Albumin Incorporating Tetrakis(o-pivalamido)phenylporphyrinatoiron(II) Derivatives Reviewed

    T. Komatsu, K. Hamamatsu, J. Wu, E. Tsuchida

    Bioconjugate Chem.   10 ( 1 )   82 - 86   1999.1

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  • リコンビナントアルブミン‐ヘム複合体の物性と酸素結合能 Reviewed

    小松晃之, 浜松和芳, 松川泰子, 呉 健, 土田英俊

    人工血液   6 ( 4 )   110 - 114   1998.12

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  • Self-Organized Monolayer Assemblies of Octopusporphyrins: Photoinduced Electron Transfer and O2 Coordination in Aqueous Media Reviewed

    E. Tsuchida, T. Komatsu, J.-H. Fuhrhop

    Polym. Adv. Technol.   9 ( 9 )   569 - 578   1998.9

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  • Monolayer Assemblies Made of Octopusporphyrins with Pyridinium Headgroups: Electron-Transfer Reactions in Noncovalent Porphyrin-Quinone Platelets in Aqueous Media Reviewed

    T. Komatsu, T. Yanagimoto, E. Tsuchida, U. Siggel, J.-H. Fuhrhop

    J. Phys. Chem. B   102 ( 35 )   6759 - 6765   1998.8

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  • Resonance Raman Studies of Dioxygen Binding to ortho-Substituted Tetraphenyl- and Tetranaphthyl-Porphyrinatoiron(II) Derivatives with a Covalently Linked Axial Imidazole Reviewed

    J. Wu, T. Komatsu, E. Tsuchida

    J. Chem. Soc., Dalton Trans.   ( 15 )   2503 - 2506   1998.8

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  • Synthesis and dioxygenation of [5,10,15,20-tetrakis(alpha,alpha,alpha,alpha-o-pivaloyloxy-naphthyl)porphinato]iron(II) with a covalently bound imidazolylalkyl group Reviewed

    T Komatsu, K Sano, E Tsuchida

    Chem. Commun.   ( 9 )   977 - 978   1998.5

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  • Lipidporhyrin Fiber: Nanostructure and Photoexcited State Properties in Aqueous Media

    T. Komatsu, T. Yanagimoto, E. Tsuchida

    Porphyrins   7(2,3)   238 - 243   1998.4

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  • Human Serum Albumin Incorporating Synthetic Hemes: O2-Coordination Structure and Properties

    J. Wu, T. Komatsu, K. Hamamatsu, E. Tsuchida

    Porphyrins   7(2,3)   427 - 432   1998.4

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  • Optimized Polyelectrolyte Stabilization Procedures for Polymeric Porphyrin Assemblies in Water Allow the Analysis of Minute Photoreactivities Reviewed

    U. Bindig, C. Endisch, J.-H. Fuhrhop, T. Komatsu, E. Tsuchida, U. Siggel

    J. Colloid Interf. Sci.   199 ( 2 )   123 - 130   1998.3

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  • Human Serum Albumin-Bound Synthetic Hemes as an Oxygen Carrier: Determination of Equilibrium Constants for Heme Binding to Host Albumin Reviewed

    T. Komatsu, K. Hamamatsu, S. Takeoka, H. Nishide, E. Tsuchida

    Artif. Cells Blood Subs. Immobil. Biotechnol.   26 ( 5-6 )   519 - 527   1998

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  • Solid Vesicle Membrane Made of meso-Tetrakis[(bixinylamino)-o-phenyl]porphyrins Reviewed

    T. Komatsu, E. Tsuchida, C. Bottcher, D. Donner, C. Messerschmidt, U. Siggel, W. Stocker, J. P. Rabe, J.-H. Fuhrhop

    J. Am. Chem. Soc.   119 ( 48 )   11660 - 11665   1997.12

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  • Properties of and Oxygen Binding by Albumin-Tetraphenylporphyrinatoiron(II) Derivative Complexes Reviewed

    E. Tsuchida, K. Ando, H. Maejima, N. Kawai, T. Komatsu, S. Takeoka, H. Nishide

    Bioconjugate Chem.   8 ( 4 )   534 - 538   1997.7

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  • Photophysical and Photochemical Properties of Porphyrin Aggregates Reviewed

    U. Siggel, U. Bindig, C. Endisch, T. Komatsu, E. Tsuchida, J. Voigt, J.-H. Fuhrhop

    Ber. Bunsenges. Phys. Chem.   100 ( 12 )   2070 - 2075   1996.12

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  • Micellar Fibers of Octopus Porphyrin, Photoinduced Electron Transfer Reactions in Aqueous Media Reviewed

    T. Komatsu, K. Yamada, E. Tsuchida, U. Siggel, C. Bottcher, J.-H. Fuhrhop

    Langmuir   12 ( 26 )   6242 - 6249   1996.12

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  • Oxygen Transporting Ability of Lipidheme Microspheres as a Totally Synthetic Red Cell Substitute Reviewed

    T. Komatsu, A. Kuronuma, Y. Muramatsu, H. Nishide, E. Tsuchida, T. Kakizaki, K. Kobayashi

    Artif. Organs Today   5 ( 3 )   207 - 215   1996.9

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  • Metalloporphyrin Heterodimers, Molecular Bilayer Fibers and Monolayer Leaflets Reviewed

    J.-H. Fuhrhop, C. Endisch, U. Bindig, B. Rosengarten, C. Bottcher, U. Siggel, E. Tsuchida, T. Komatsu

    Macormol. Symp.   105   27 - 42   1996.3

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  • ヘム結合ヒト血清アルブミンの調製と酸素結合能 Reviewed

    川合宣行, 安藤克利, 小松晃之, 西出宏之, 土田英俊

    人工血液   3 ( 4 )   103 - 105   1995.12

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  • Characteristic O2-Binding of Lipidprotoheme in Phospholipid Bilayer Membrane Reviewed

    N. Kawai, T. Komatsu, T. Yanagimoto, H. Nishide, E. Tsuchida

    Chem. Lett.   24 ( 6 )   477 - 478   1995.6

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  • O2-Transport Albumin: A New Hybrid-Haemoprotein Incorporating Tetraphenylporphinatoiron(II) Derivative Reviewed

    T. Komatsu, K. Ando, N. Kawai, H. Nishide, E. Tsuchida

    Chem. Lett.   24 ( 9 )   813 - 814   1995.6

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  • Self-Assembled Lipidporphyrin Bilayer Vesicles. Microstructure and Dioxygen Binding in Aqueous Medium Reviewed

    E. Tsuchida, T. Komatsu, K. Arai, K. Yamada, H. Nishide, J.-H. Fuhrhop

    Langmuir   11 ( 6 )   1877 - 1884   1995.6

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  • Monolayered Octopus-Porphyrin Vesicle: Microstructure and Oxygen-Binding in Aqueous Medium Reviewed

    E. Tsuchida, T. Komatsu, K. Arai, K. Yamada, H. Nishide, C. Böttcher, J.-H. Fuhrhop

    J. Chem. Soc. Chem. Commun.   ( 10 )   1063 - 1064   1995.5

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  • ポリフィリン集合体と電子過程 Invited Reviewed

    土田英俊, 小松晃之

    化学   50 ( 4 )   54 - 55   1995.4

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  • Synthesis and O2-Binding Properties of Tetraphenylporphyrinatoiron(II) Derivatives Bearing a Proximal Imidazole Covalently Bound at the β-pyrrolic Position Reviewed

    E. Tsuchida, T. Komatsu, S. Kumamoto, K. Ando, H. Nishide

    J. Chem. Soc., Perkin Trans. 2   ( 4 )   747 - 753   1995.4

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  • トリグリセリド型塩基を含有したリピドヘム微小球の構成と酸素親和性 Reviewed

    小松晃之, 村松靖子, 西出宏之, 土田英俊

    人工血液   2 ( 4 )   94 - 96   1994.12

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  • A new totally synthetic oxygen carrier: Lipid heme microshere(LHM)

    K. Kobayashi, T. Kakizaki, Y. Izumi, S. Takeoka, T. Komatsu, H. Nishide, E. Tsuchida

    Artificial Cells, Blood Substitutes, and Immobilization Biotechnology   22 ( 5 )   A117   1994.11

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  • Synthesis of Protoporphyrin IX Derivatives Having Four Amphiphilic and/or Lipophilic Alkyl Chains and Their Dispersing Behavior in Phospholipid Bilayer Reviewed

    T. Komatsu, K. Yamada, S. Yanagisawa, H. Nishide, E. Tsuchida

    Chem. Lett.   23 ( 10 )   1953 - 1956   1994.10

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  • 人工赤血球（リピドヘムマイクロスフェア）の体内酸素運搬 Reviewed

    小松晃之

    人工臓器   23 ( 3 )   849 - 853   1994.7

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    In vivo O2-transporting ability of totally synthetic artificial red cell (lipid-heme-microsphere) is described. O2-Binding affinity of the lipid-heme-microsphere (P1/2(O2): ca. 40 Torr at 37°C) was slightly lower than that of red cell (human blood) and its O2-association and-dissociation rate constants were larger than those of hemoglobin. O2-Solubility of the lipid-heme-microsphere dispersion was estimated. Highly O2-dissolved aqueous solution can be prepared by the prescription of the lipid-heme-microsphere. The totally synthetic artificial red cell suspension was intravenously injected into hemorrhagic beagles (8kg). Circulation life-time of the each constituent of this system and O2-consumption by the lipid-heme was determined. These results suggest that the lipid-heme-microsphere has an ability to act as an efficient O2-carrier in blood stream.

    DOI： 10.11392/jsao1972.23.849

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  • Structure and Solution Properties of Lipidheme-Microsphere Reviewed

    T. Komatsu, H. Nishide, E. Tsuchida

    Art. Cell. Blood Sub. Immob. Biotech.   22 ( 3 )   855 - 860   1994

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  • Lipidheme-Microsphere (LH-M). A New Type of Totally Synthetic Oxygen Carrier and Its Oxygen Carrying Ability Reviewed

    T. Kakizaki, K. Kobayashi, T. Komatsu, H. Nishide, E. Tsuchida

    Art. Cell. Blood Sub. Immob. Biotech.   22 ( 3 )   933 - 938   1994

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  • Two Types of Totally Artificial Red Blood Cell Substitutes −Liposome Embedded Heme (L/H) and Lipidheme-Microsphere (LH-M) Reviewed

    K. Kobayashi, T. Kakizaki, T. Komatsu, H. Nishide, E. Tsuchida

    Art. Cell. Blood Sub. Immob. Biotech.   22 ( 3 )   895 - 900   1994

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  • Lipid-Porphyrin Fibers: Morphology and Incorporation into Phospholipid Vesicle Reviewed

    E. Tsuchida, T. Komatsu, N. Toyano, S. Kumamoto, H. Nishide

    J. Chem. Soc., Chem. Commun.   ( 23 )   1731 - 1733   1993.12

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  • Synthesis and Aggregate Morphology of Protoporphyrin IX Derivative Having Phospholipid Residue Reviewed

    T. Komatsu, K. Arai, H. Nishide, E. Tsuchida

    Chem. Lett.   22 ( 11 )   1949 - 1952   1993.11

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  • Synthesis and Dioxygen-Binding Properties of Double-Sided Porphyrinatoiron(II) Complexes Bearing Covalently Bound Axial Imidazole Reviewed

    E. Tsuchida, T. Komatsu, K. Arai, H. Nishide

    J. Chem. Soc., Dalton Trans.   ( 16 )   2465 - 2469   1993.8

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  • O2 and CO Binding Behavior of Double-Sided Porphyrinatoiron(II) Complexes Modified with Amide Residues Reviewed

    T. Komatsu, S. Kumamoto, H. Nishide, E. Tsuchida

    Bull. Chem. Soc. Jpn.   66 ( 6 )   1640 - 1646   1993.6

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  • Octopus-Porphyrins: Their Assembly and Oxygen-Binding in Aqueous Medium Reviewed

    T. Komatsu, K. Nakao, H. Nishide, E. Tsuchida

    J. Chem. Soc., Chem. Commun.   ( 9 )   728 - 730   1993.5

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  • Lipid-Porphyrin Vesicles: Morphology and O2 Binding in Aqueous Medium Reviewed

    E. Tsuchida, T. Komatsu, K. Arai, H. Nishide

    J. Chem. Soc., Chem. Commun.   ( 9 )   730 - 732   1993.5

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  • 錯体の分子集合と構造制御 Reviewed

    土田英俊, 小松晃之

    高分子   42 ( 5 )   422 - 425   1993.5

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    DOI： 10.1295/kobunshi.42.422

    CiNii Books

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  • Preparation and Oxygen-Transport of Artificial Red Cells (Lipidheme-Microspheres) Reviewed

    E. Tsuchida, T. Komatsu, N. Kawai, H. Nishide, T. Kakizaki, K. Kobayashi

    Artif. Organs Today   3 ( 2 )   137 - 143   1993.4

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  • Synthesis of Porphinatoirons Having an Alkyl Amphiphilic Chain and Their O2-Binding Properties in Lipid Bilayer Reviewed

    E. Tsuchida, H. Nishide, E. Hasegawa, Y. Chika, M. Fukuzumi, T. Komatsu

    J. Inorg. Biochem.   49 ( 4 )   255 - 264   1993.3

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  • リピドヘム-マイクロスフェア（人工赤血球）の物性と酸素輸送 Reviewed

    小松晃之, 荒井健次, 川合宣行, 西出宏之, 土田英俊, 柿崎 徹, 小林紘一

    人工臓器   22 ( 2 )   550 - 553   1993.3

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    Solution properties and O2 transporting ability of lipidheme-microsphere composed of oil droplet covered with lipidheme (totally synthetic artificial red cell) are described. Electron micrographs indicated microsphere formation and its particle diameter was controlled from 30 to 200nm. The suspension was characterized by its low viscosity (1, 2cP), specific gravity (1.001), and controlled oncotic pressure. The lipidheme-microsphere bound oxygen reversibly and the P1/2(O2) was 41 torr at 37°C. O2 solubility of the lipidheme-microsphere was more than that of human blood caused by its high heme concentration. Exchange transfusion with the suspension to dogs weighing ca. 8kg was carried out and circulation half life in blood stream was determined (12hr). This result suggests that the lipidheme-microsphere has potential to act as an efficient oxygen carrier in blood stream.

    DOI： 10.11392/jsao1972.22.550

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  • Lipid Microsphere Containing Lipophilic Heme: Preparation and Oxygen Transportation under Physiological Conditions Reviewed

    E. Tsuchida, H. Nishide, T. Komatsu, K. Yamamoto, E. Matsubuchi, K. Kobayashi

    Biochim. Biophys. Acta.   1108 ( 2 )   253 - 256   1992.7

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  • Lipid-Heme/Microsphere. A New Totally Synthetic Oxygen-Carrier under Physiological Conditions Reviewed

    T. Komatsu, E. Matsubuchi, H. Nishide, E. Tsuchida

    Chem. Lett.   21 ( 7 )   1325 - 1328   1992.7

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  • Double-Sided Porphyrinatoiron(II) Bearing Covalently Bound Imidazole. An Efficient Oxygen-Carrier Molecule Composed by 8 Ester Bonds Reviewed

    T. Komatsu, K. Arai, H. Nishide, E. Tsuchida

    Chem. Lett.   21 ( 5 )   799 - 802   1992.5

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  • 人工赤血球（リピドヘム）による in vivo 血流中での酸素運搬 Reviewed

    小松晃之, 松渕永里子, 西出宏之, 土田英俊, 渡辺真純, 小林紘一, 石原恒夫

    人工臓器   21 ( 1 )   299 - 303   1992.1

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    In vivo oxygen transporting capacity of totally synthetic artificial red cell (poly-liposome embedded lipid-heme) solution, which can bind and release molecular oxygen under physiological condition, was described. Exchange transfusion with the lipid-heme solution to six dogs weighing about 8kg was carried out. After the transfusion with 30ml/kg of the lipid-heme solution, the oxygen partial pressure of mixed venous blood increased from 30 to 50mmHg. Oxygen consumption by the lipid-heme was calculated to be 15ml/min (20% of total oxygen transport), which is corresponding to the lipid-heme concentration in the blood stream. Circulation half-life time in the blood stream was about 11hr. for the lipid-heme and about 26hr. for the liposome. Oxidation rate of the lipid-heme (met-formation) in the blood stream was slower than that of in vitro: only 6% of the lipid-heme was oxidized at 11hr. after the injection.

    DOI： 10.11392/jsao1972.21.299

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  • Metal-Ligand Bonding Properties of Double-Sided Porphyrin Complexes: Influence of Bulky Ester Groups Reviewed

    E. Tsuchida, T. Komatsu, T. Nakata, E. Hasegawa, H. Nishide, H. Inoue

    J. Chem. Soc., Dalton Trans.   ( 12 )   3285 - 3289   1991.12

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  • Kinetics of Binding of O2 and CO to ‘Double-Sided’ Porphyrinatoiron(II) Complexes Reviewed

    T. Komatsu, E. Hasegawa, S. Kumamoto, H. Nishide, E. Tsuchida

    JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS   ( 12 )   3281 - 3284   1991.12

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  • Synthesis and Coordination Behavior of New Double-Sided Porphyrinatoiron(II) Complexes: Effect of the Pocket-Size for Imidazole on Dioxygen Binding Reviewed

    E. Tsuchida, E. Hasegawa, T. Komatsu, T. Nakata, K. Nakao, H. Nishide

    Bull. Chem. Soc. Jpn.   64 ( 3 )   888 - 894   1991.3

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  • Synthesis, Characterization, and Oxygenation of Bis-Fenced Porphyrinato Iron(II) and Cobalt(II) Complexes Reviewed

    E. Tsuchida, T. Komatsu, E. Hasegawa, H. Nishide

    J. Chem. Soc. Dalton Trans.   ( 9 )   2713 - 2718   1990.9

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  • Amphiphilic Porphinatoirons Having Steroid Groups and Their Oxygen-Adduct Formation in an Aqueous Medium Reviewed

    E. Tsuchida, T. Komatsu, T. Babe, T. Nakata, H. Nishide, H. Inoue

    Bull. Chem. Soc. Jpn.   63 ( 8 )   2323 - 2327   1990.8

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  • A Bis-Fenced Porphinatoiron Having Seven Pivaloyloxy Groups on the Porphyrin Ring Plane. Synthesis and Ligand Binding Reviewed

    E. Tsuchida, E. Hasegawa, T. Komatsu, K. Nakao, H. Nishide

    Chem. Lett.   19 ( 7 )   1071 - 1074   1990.7

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  • Synthesis and Characterization of a Membrane-Spanning Porphinatorion(II) Reviewed

    E. Tsuchida, E. Hasegawa, T. Komatsu, T. Nakata, H. Nishide

    Chem. Lett.   19 ( 3 )   389 - 392   1990.3

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  • Oxygenation of a New Bis-Fenced Porphyrinato Iron without Amide Groups: 5,10,15,20-Tetrakis(2,6-bispivaloyloxyphenyl)porphyrinatoiron(II) Reviewed

    T. Komatsu, E. Hasegawa, H. Nishide, E. Tsuchida

    J. Chem. Soc., Chem. Commun.   ( 1 )   66 - 68   1990.1

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Books

  • Functional Macromolecular Complexes (Coordination Chemistry Discovery Series No. 1)

    Y. Morita, T. Komatsu（ Role： ContributorDevelopment of Artificial O2 Carriers as Red Blood Cell Substitutes）

    Royal Society of Chemistry (London)  2024.11 

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  • Frontier Functional Macromolecule-Metal Complexes

    Y. Morita, T. Komatsu（ Role： ContributorDevelopment of Artificial Oxygen Carriers as Red Blood Cell Substitutes）

    Sankyo Shuppan (Tokyo)  2020.6 

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  • Albumin in Medicine. Pathological and Clinical Applications

    T. Komatsu（ Role： ContributorHemoglobin-Albumin Clusters as a Red Blood Cell Substitute）

    Springer (Tokyo)  2016.12 

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    Responsible for pages：p. 165–178 (Chapter 9)   Language：English   Book type：Scholarly book

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  • 超分子材料の設計と応用展開

    小松晃之, 秋山元英（ Role： Contributorタンパク質ナノチューブの合成と応用展開）

    シーエムシー出版  2014.9 

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    Responsible for pages：p. 64-71   Language：Japanese   Book type：Scholarly book

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  • Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics

    T. Komatsu（ Role： Joint authorAlbumin-Heme Oxygen Carriers）

    Springer-Verlag  2013 

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    Responsible for pages：p. 339-348   Language：English   Book type：Scholarly book

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  • Human Serum Albumin –New Insights on its Structural Dynamics, Functional Impacts and Pharmaceutical Applications

    T. Komatsu（ Role： Joint authorAlbumin-Heme as an O2-Carrying Plasma Protein）

    Sojo University Publishing Co  2011.7 

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    Responsible for pages：p. 281-295   Language：English   Book type：Scholarly book

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  • 有機・無機・金属ナノチューブ－非カーボンナノチューブ系の最新技術と応用展開

    小松晃之（ Role： Sole author交互積層法による蛋白質ナノチューブの合成）

    フロンティア出版  2008.3 

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    Responsible for pages：p. 82-88   Language：Japanese   Book type：Scholarly book

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  • Blood Substitutes

    T. Komatsu, Y. Huang, H. Yamamoto, H. Horinouchi, K. Kobayashi, E. Tsuchida（ Role： ContributorAlbumin-Heme: A Synthetic Heme-Based Oxygen Carrier）

    Elsevier (London)  2006.10 

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    Responsible for pages：p. 532-539   Language：English   Book type：Scholarly book

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  • 人工臓器・再生医療の最先端

    土田英俊, 酒井宏水, 小松晃之, 小林紘一（ Role： Joint author酸素輸液（人工赤血球）の臨床応用）

    先端医療技術研究所  2006.1 

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  • Artificial Oxygen Carrier. Its Front Line

    T. Komatsu, E. Tsuchida（ Role： Joint authorOxygen-Carrying Plasma Hemoprotein Including Synthetic Heme）

    Springer-Verlag (Tokyo)  2005.11 

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  • Artificial Oxygen Carrier. Its Front Line

    K. Kobayashi（ Role： Joint authorSafety and Efficacy of Hemoglobin-Vesicles and Albumin-Hemes）

    Springer-Verlag (Tokyo)  2005.11 

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    Responsible for pages：p. 1-21   Language：English   Book type：Scholarly book

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  • ソフトマテリアルの新展開

    西出宏之, 小松晃之, 土田英俊（ Role： Joint author疎水ポルフィリン組織体の構築と酸素の運搬）

    シーエムシー出版  2004.11 

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  • 新訂版・表面科学の基礎と応用

    土田英俊, 武岡真司, 小松晃之, 酒井宏水（ Role： Joint author人工赤血球）

    エヌ・ティー・エス  2004.6 

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    Responsible for pages：p. 1333-1336   Language：Japanese   Book type：Scholarly book

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  • Blood Substitutes. Present and Future Perspectives

    T. Komatsu, E. Tsuchida, K. Kobayashi（ Role： Joint authorOxygen-Transport Albumin: A New Hemoprotein Incorporating Lipidhemes as a Red Cell Substitute）

    Elsevier Science (New York)  1998.10 

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    Responsible for pages：p. 315-236   Language：English   Book type：Scholarly book

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  • Macromolecule-Metal Complexes

    （ Role： Joint authorAssembled Porphyrins and Oxygen Coordination）

    Springer-Verlag (Berlin)  1996.4 

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    Responsible for pages：p. 190-210   Language：English   Book type：Scholarly book

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  • Methods in Enzymology Vol. 231, Hemoglobin Part B

    E. Tsuchida, T. Komatsu（ Role： Joint authorSynthetic Hemes）

    Academic Press (San Diego)  1994.4 

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    Responsible for pages：p. 167-193   Language：English   Book type：Scholarly book

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  • 新生化学実験講座 Vol. 7

    土田英俊, 武岡真司, 小松晃之（ Role： Joint authorバイオマテリアル（人工赤血球））

    東京化学同人  1993.5 

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MISC

  • ヘモグロビン-アルブミン複合体HemoActによる脳虚血再灌流急性期治療の開発

    月花 正幸, 鐙谷 武雄, 小松 晃之, 船木 亮佑, 栗栖 宏太, 新保 大輔, 伊藤 康裕, 中山 若樹, 数又 研, 寳金 清博

    脳循環代謝   30 ( 1 )   115 - 115   2018.10

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  • ヘモグロビン‐アルブミン複合体HemoActによる脳虚血再灌流急性期治療の開発

    月花正幸, 鐙谷武雄, 小松晃之, 船木亮佑, 栗栖宏太, 新保大輔, 伊藤康裕, 中山若樹, 数又研, 寳金清博

    脳循環代謝(Web)   30 ( 1 )   115 - 115   2018.10

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  • ヘモグロビン-アルブミン複合体による脳虚血再灌流急性期治療

    月花 正幸, 鐙谷 武雄, 小松 晃之, 船木 亮佑, 栗栖 宏太, 新保 大輔, 中山 若樹, 数又 研, 寳金 清博

    脳循環代謝   29 ( 1 )   217 - 217   2017.11

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  • ヘモグロビン‐アルブミン複合体による脳虚血再灌流急性期治療

    月花正幸, 鐙谷武雄, 小松晃之, 船木亮佑, 栗栖宏太, 新保大輔, 中山若樹, 数又研, 寳金清博

    脳循環代謝(Web)   29 ( 1 )   217 - 217   2017.11

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  • 機能性蛋白質製剤の最前線 脳梗塞治療薬としてのヘモアクトの効果

    鐙谷 武雄, 月花 正幸, 小松 晃之, 船木 亮佑, 川堀 真人, 長内 俊也, 中山 若樹, 数又 研, 寳金 清博

    人工血液   25 ( 1 )   26 - 26   2017.11

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  • 機能性蛋白質製剤の最前線 脳梗塞治療薬としてのヘモアクトの効果

    鐙谷 武雄, 月花 正幸, 小松 晃之, 船木 亮佑, 川堀 真人, 長内 俊也, 中山 若樹, 数又 研, 寳金 清博

    人工血液   25 ( 1 )   26 - 26   2017.11

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  • ヘモグロビン‐アルブミン複合体による脳虚血再灌流急性期治療

    月花正幸, 鐙谷武雄, 小松晃之, 船木亮佑, 栗栖宏太, 新保大輔, 中山若樹, 数又研, 寳金清博

    脳循環代謝(Web)   29 ( 1 )   217 - 217   2017.11

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  • 人工酸素運搬体HemoActを用いた脳虚血再灌流障害に対する脳保護療法

    月花正幸, 鐙谷武雄, 小松晃之, 船木亮佑, 栗栖宏太, 中山若樹, 数又研, 寶金清博

    人工血液   24 ( 1 )   33 - 33   2016.10

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  • 人工血液の基礎研究と臨床への応用 人工赤血球 研究開発の現状と臨床応用

    堀之内 宏久, 小林 紘一, 渡辺 真純, 泉 陽太郎, 江口 圭介, 山本 学, 武岡 真司, 酒井 宏水, 小松 晃之, 土田 英俊

    人工臓器   31 ( 2 )   S94 - S94   2002.9

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Presentations

  • Polyoxazoline-Conjugated Hemoglobin as a Red Blood Cell Substitute Invited

    T. Komatsu

    ACS Spring 2025  2025.3 

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  • ユニバーサル赤血球としての高分子結合赤血球の開発【優秀講演賞受賞】

    藤田真悠花, 河野光智, 小松晃之

    第31回日本血液代替物学会年次大会  2024.12 

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  • 動物用人工血漿“Aloxa”の有効性評価：出血性ショックラットの蘇生試験

    藤澤隼矢, 服部亮太, 河野光智, 小松晃之

    第31回日本血液代替物学会年次大会  2024.12 

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  • 人工酸素運搬体“ポリオキサゾリン結合ヘモグロビンナノ粒子”の合成

    荒木巴佳, 小松晃之

    第31回日本血液代替物学会年次大会  2024.12 

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  • ヘモグロビンナノ粒子製剤のOne-pot調製法の確立

    高峯晃生, 小松晃之

    第31回日本血液代替物学会年次大会  2024.12 

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  • ドキソルビシン担持一酸化炭素結合型ヘモグロビン-アルブミンクラスター～ドキソルビシン心毒性を抑制する抗がん剤としての可能性～ Invited

    伊藤千尋, 田口和明, 山田大雅, 榎木裕紀, 小松晃之, 松元一明

    第31回日本血液代替物学会年次大  2024.12 

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  • 亜鉛置換HemoActの合成と光線力学療法への応用 Invited

    山田大雅, 小松晃之

    第31回日本血液代替物学会年次大会  2024.12 

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  • ヘモグロビンナノ粒子を用いた脳梗塞治療 Invited

    鐙谷武雄, 舘澤諒大, 藤村 幹, 小松晃之

    第31回日本血液代替物学会年次大会  2024.12 

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  • ヘモアクト（HemoAct）型人工酸素運搬体製剤の開発状況 Invited

    小松晃之

    第31回日本血液代替物学会年次大会  2024.12 

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  • Polyoxazoline-Conjugated Hemoglobin as an Alternative to PEGylated Hemoglobin

    T. Komatsu

    19th International Symposium on Blood Substitutes 2024  2024.11 

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  • ポリオキサゾリン結合ウリカーゼの合成と酵素活性評価

    庄司拓真, 山田大雅, 小松晃之

    第14回化学フェスタ2024  2024.10 

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  • ビオチン化アルブミンの有無を識別できる高分子チューブマイクロモーターの合成

    木村光里, 山田大雅, 小松晃之

    第73回高分子討論会  2024.9 

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  • 水中で自走する高分子チューブマイクロモーターの創製と応用 Invited

    小松晃之

    第73回高分子討論会  2024.9 

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  • 水中で自走する高分子チューブマイクロモーターの合成と機能 Invited

    小松晃之

    電子情報通信学会ソサイエティ大会  2024.9 

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  • Velocity Control of Polymer-Based Tubular Micromotors by Visible Light Irradiation【Poster Presentation Award】

    S. Batori, T. Komatsu

    Cutting-edge Nanotechnologies for Good Health and Well-being  2024.7 

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  • Surface Decoration of Red Blood Cells with Polyoxazoline to Mask RhD Antigens【Poster Presentation Award】

    M. Fujita, T. Komatsu

    Cutting-edge Nanotechnologies for Good Health and Well-being  2024.7 

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  • Hemoglobin-Albumin Cluster ”HemoAct” as Red Blood Cell Substitute and O2 Therapeutics Invited

    T. Komatsu

    Cutting-edge Nanotechnologies for Good Health and Well-being  2024.7 

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  • 新規人工血液ポリオキサゾリン結合アルブミンの構造確認

    西風隆司, 山崎雄三, 小松晃之

    第72回質量分析総合討論会  2024.6 

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  • リポソームを輸送できる高分子チューブマイクロモーターの合成と薬物放出【優秀ポスター賞受賞】

    馬鳥沙希, 小松晃之

    第73回高分子学会年次大会  2024.6 

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  • 水中で自走する酸化チタン被覆高分子チューブマイクロモーターの大腸菌殺傷能

    坂井悠真, 小松晃之

    第73回高分子学会年次大会  2024.6 

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  • 動物用人工酸素運搬体と人工血漿の開発 Invited

    小松晃之

    日本獣医輸血研究会・小動物臨床血液研究会（第2回共催学術講習会）  2024.5 

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  • 人工酸素運搬体としてポリオキサゾリン被覆ヘモグロビンナノ粒子の合成

    荒木巴佳, 高山夏実, 小松晃之

    日本化学会第104春季年会  2024.3 

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  • 亜鉛フタロシアニン置換ミオグロビン-アルブミン融合タンパク質の合成と光殺菌能

    江川 碧, 山田大雅, 小松晃之

    日本化学会第104春季年会  2024.3 

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  • 人工酸素運搬体としてポリ（2-アルキル-2-オキサゾリン）結合ヘモグロビンの合成

    若林竜平, 石井幸太, 小松晃之

    日本化学会第104春季年会  2024.3 

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  • ポリ（2-アルキル-2-オキサゾリン）結合血清アルブミンの合成

    服部亮太, 藤澤隼矢, 小松晃之

    日本化学会第104春季年会  2024.3 

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  • アビジン-ビオチン結合を利用した高分子チューブマイクロモーターの合成

    木村光里, 小松晃之

    日本化学会第104春季年会  2024.3 

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  • Hemoglobin-Based O2 Carriers as a Red Blood Cell Substitute Invited

    T. Komatsu

    13th Japan-China Joint Symposium on Metal Cluster Compounds  2024.3 

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  • ユニバーサル赤血球としてのポリオキサゾリン結合赤血球の合成と酸素親和性【学生講演賞受賞】

    藤田真悠花, 小松晃之

    第30回日本血液代替物学会年次大会  2023.12 

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  • 人工酸素運搬体“ストロマフリーヘモグロビンナノ粒子”の有効性評価（50%出血性ショックラットの蘇生試験）【学生講演賞受賞】

    高山夏実, 藤田真悠花, 河野光智, 小松晃之

    第30回日本血液代替物学会年次大会  2023.12 

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  • ポリオキサゾリン結合数の異なるHemoxa（人工酸素運搬体）の合成と機能

    石井幸太, 小松晃之

    第30回日本血液代替物学会年次大会  2023.12 

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  • ポリオキサゾリン結合数の異なるAloxa（動物用人工血漿）の合成と機能

    藤澤隼矢, 岡本 航, 河野光智, 小松晃之

    第30回日本血液代替物学会年次大会  2023.12 

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  • 酸化チタンナノ粒子で被覆した高分子マイクロチューブモーターの合成と大腸菌殺傷能

    坂井悠真, 小松晃之

    第13回CSJ化学フェスタ2023  2023.10 

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  • ウイルス形状ナノ粒子を捕集する高分子マイクロチューブモーターの合成

    橋本真衣, 小松晃之

    第13回CSJ化学フェスタ2023  2023.10 

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  • 水素バブルで自走する高分子マイクロチューブモーターの合成とニトロ化合物の還元

    蒲地海州, 小松晃之

    第13回CSJ化学フェスタ2023  2023.10 

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  • 光照射で速度制御可能な高分子マイクロチューブモーターの合成【優秀ポスター賞受賞】

    馬鳥沙希, 小松晃之

    第72回高分子討論会  2023.9 

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  • 高分子結合アスパラギナーゼの合成と抗がん活性

    庄司拓真, 山田大雅, 小松晃之

    第72回高分子討論会  2023.9 

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  • （亜鉛置換ヘモグロビン‐アルブミン）クラスターの合成と光線力学活性

    勝見真帆, 山田大雅, 小松晃之

    錯体化学会第73回討論会  2023.9 

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  • Hemoprotein-Albumin Clusters Incorporating Protoporphyrin IX for Enhanced Photodynamic Therapy

    山田大雅, 勝見真帆, 小松晃之

    錯体化学会第73回討論会  2023.9 

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  • 亜鉛フタロシアニン置換ミオグロビン‐アルブミン融合タンパク質の合成と抗がん活性

    舩本瑞稀, 山田大雅, 小松晃之

    錯体化学会第73回討論会  2023.9 

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  • ポリ（2-エチル-2-オキサゾリン）結合アルブミンの合成と構造

    藤澤隼矢, 臼井朝音, 岡本 航, 小松晃之

    日本化学会第103春季年会  2023.3 

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  • 酸化チタンナノ粒子で被覆した高分子マイクロチューブモーターの合成

    坂井悠真, 加藤 遼, 小松晃之

    日本化学会第103春季年会  2023.3 

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  • 内孔表面にカタラーゼを有する高分子マイクロチューブモーターの合成

    馬鳥沙希, 加藤 遼, 小松晃之

    日本化学会第103春季年会  2023.3 

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  • ポリ（2-エチル-2-オキサゾリン）結合アスパラギナーゼの合成と細胞毒性

    庄司拓真, 石丸真里花, 山田大雅, 小松晃之

    日本化学会第103春季年会  2023.3 

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  • コア-シェル型構造のストロマフリーヘモグロビンナノ粒子の合成と酸素結合能

    高峯晃生, 岡本 航, 高山夏実, 小松晃之

    日本化学会第103春季年会  2023.3 

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  • 表面にポリオキサゾリンを結合した赤血球の合成

    藤田真悠花, 岡本 航, 吉田瑠佳, 小松晃之

    日本化学会第103春季年会  2023.3 

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  • 動物用人工血漿増量剤“Aloxa”の安全性および有効性評価

    臼井朝音, 岡本 航, 橋本 諒, 小野沢博登, 岩﨑正之, 河野光智, 田口和明, 小松晃之

    第29回日本血液代替物学会年次大会  2022.12 

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  • ポリオキサゾリン修飾ヘモグロビン“Hemoxa”の合成と酸素結合能

    小林樹広, 岡本 航, 加藤 遼, 小松晃之

    第29回日本血液代替物学会年次大会  2022.12 

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  • 抗酸化能を有する人工酸素運搬体“ストロマフリーヘモグロビンナノ粒子（SFHbNP）”の開発【学生講演賞受賞】

    高山夏実, 岡本 航, 小松晃之

    第29回日本血液代替物学会年次大会  2022.12 

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  • ポリオキサゾリン修飾赤血球の開発【学生講演賞受賞】

    吉田瑠佳, 岡本 航, 小松晃之

    第29回日本血液代替物学会年次大会  2022.12 

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  • ポリオキサゾリン修飾ヘモグロビン“Hemoxa”の有効性評価（50%出血性ショックラットの蘇生試験）（依頼講演） Invited

    岡本 航, 臼井朝音, 橋本 諒, 小野沢博登, 岩﨑正之, 河野光智, 小松晃之

    第29回日本血液代替物学会年次大会  2022.12 

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  • プロトポルフィリン結合HemoAct製剤の合成と光線力学療法への応用（依頼講演）【最優秀学生講演賞受賞】 Invited

    山田大雅, 勝見真帆, 小松晃之

    第29回日本血液代替物学会年次大会  2022.12 

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  • ヘモアクト型人工酸素運搬体製剤の最新動向（依頼講演） Invited

    Teruyuki Komatsu

    第29回日本血液代替物学会年次大会  2022.12 

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  • Hemoglobin-Based O2 Carriers as Red Blood Cell Substitutes Prepared using Maleimide-Thiol Conjugates Invited

    T. Komatsu

    10th Asia Biological Inorganic Chemistry (AsBIC10)  2022.12 

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  • 動物用人工血漿増量剤“ポリオキサゾリン修飾アルブミン”の合成と有効性

    臼井朝音, 岡本 航, 河野光智, 田口和明, 小松晃之

    第12回CSJ化学フェスタ2022  2022.10 

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  • （亜鉛置換ヘモグロビン‐アルブミン）クラスターの合成

    石井幸太, 勝見真帆, 山田大雅, 小松晃之

    第12回CSJ化学フェスタ2022  2022.10 

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  • （亜鉛ヘモグロビン‐アルブミン）クラスターの合成と光線力学活性

    勝見真帆, 山田大雅, 小松晃之

    錯体化学会第72回討論会  2022.9 

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  • がん治療光増感剤としてのプロトポルフィリン IX 結合(カタラーゼ‐アルブミン)クラスターの合成

    山田大雅, 勝見真帆, 小松晃之

    錯体化学会第72回討論会  2022.9 

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  • 白血病治療薬としてのポリオキサゾリン修飾L-アスパラギナーゼの合成と抗がん活性

    石丸真里花, 山田大雅, 小松晃之

    第71回高分子討論会  2022.9 

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  • タンパク質マイクロチューブモーターによるウイルス形状蛍光ナノ粒子の選択的捕集

    明石勇志, 加藤 遼, 小松晃之

    第71回高分子討論会  2022.9 

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  • 高分子マイクロチューブモーターを用いたビオチン化合物の検出

    橋本真衣, 加藤 遼, 小松晃之

    第71回高分子討論会  2022.9 

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  • 水素バブルの噴射で自走する高分子マイクロチュー ブモーターの合成

    加藤 遼, 蒲地海州, 小松晃之

    第71回高分子学会年次大会  2022.5 

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  • プロトポルフィリン結合（カタラーゼ-アルブミン）クラスターの光線力学活性

    山田大雅, 勝見真帆, 小松晃之

    第71回高分子学会年次大会  2022.5 

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  • 水素バブルで自走する高分子マイクロチューブモーターの合成

    蒲地海州, 加藤 遼, 小松晃之

    日本化学会第102春季年会  2022.3 

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  • アビジン被覆高分子マイクロチューブモーターの合成とビオチン捕捉

    橋本真衣, 加藤 遼, 小松晃之

    日本化学会第102春季年会  2022.3 

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  • プロトポルフィリンIX結合（カタラーゼ-アルブミン）クラスターの合成と光線力学活性

    勝見真帆, 山田大雅, 小松晃之

    日本化学会第102春季年会  2022.3 

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  • 光線力学療法のためのアルブミン-ミオグロビン融合タンパク質の合成

    舩本瑞稀, 高田諒也, 森田能次, 小松晃之

    日本化学会第102春季年会  2022.3 

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  • 人工酸素運搬体としてのストロマフリーヘモグロビンナノ粒子の合成と抗酸化能評価

    高山夏実, 岡本 航, 長谷川 舞, 小松晃之

    日本化学会第102春季年会  2022.3 

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  • アルブミン-ミオグロビン融合タンパク質の合成【ポスター賞受賞】

    高田諒也, 森田能次, 小松晃之

    第11回CSJ化学フェスタ2021  2021.10 

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  • 過酸化水素水溶液中で自走する高分子マイクロチューブモーターの合成

    菅原智直, 加藤 遼, 小松晃之

    第11回CSJ化学フェスタ2021  2021.10 

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  • 動物用人工血漿増量剤としてのポリオキサゾリン修飾血清アルブミン（Aloxa™）の合成

    臼井朝音, 岡本 航, 橋本 諒, 小野沢博登, 河野光智, 岩﨑正之, 小松晃之

    第28回日本血液代替物学会年次大会  2021.10 

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  • 抗酸化能を有するストロマフリーヘモグロビンナノ粒子（SFHbNP）の合成【最優秀発表賞受賞】

    長谷川舞, 岡本 航, 小松晃之

    第28回日本血液代替物学会年次大会  2021.10 

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  • HemoAct™の安全性・有効性評価（50%出血性ショックラットの蘇生試験）【優秀発表賞受賞】

    岡本 航, 長谷川舞, 臼井朝音, 橋本 諒, 小野沢博登, 河野光智, 岩﨑正之, 小松晃之

    第28回日本血液代替物学会年次大会  2021.10 

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  • 酸素吸脱着により構造変化する組換えヘモグロビン集合体の合成

    吉田瑠佳, 森田能次, 小松晃之

    錯体化学会第71回討論会  2021.9 

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  • ビスターピリジン鉄錯体で連結したヘモグロビン超構造体の合成と形態制御

    澤口玲実, 森田能次, 小松晃之

    錯体化学会第71回討論会  2021.9 

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  • 抗酸化剤を結合した（ヘモグロビン-アルブミン）クラスターの合成

    石丸真里花, 山田大雅, 小松晃之

    第15回バイオ関連化学シンポジウム  2021.9 

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  • 組換えヘモグロビンナノ粒子の合成と酸素結合能

    小林樹広, 岡本 航, 長谷川舞, 森田能次, 小松晃之

    第15回バイオ関連化学シンポジウム  2021.9 

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  • 酵素被覆タンパク質マイクロチューブモーターの合成と触媒反応

    梅原瑞希, 加藤 遼, 小松晃之

    第70回高分子討論会  2021.9 

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  • 人工ウイルス粒子捕集能を有するタンパク質マイクロチューブモーターの合成

    明石勇志, 加藤 遼, 小松晃之

    第70回高分子討論会  2021.9 

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  • 鋳型内光重合法による高分子マイクロチューブモーターの合成（依頼講演）

    加藤 遼, 菅原智直, 小松晃之

    第70回高分子討論会  2021.9 

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  • 協同効果を有する人工酸素運搬体（ヘモグロビン-アルブミン）トリマーの合成と酸素親和性制御（依頼講演）

    森田能次, 小松晃之

    第70回高分子討論会  2021.9 

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  • α99 位置アミノ酸置換ヘモグロビンの合成と酸素親和性

    吉田瑠佳, 森田能次, 小松晃之

    第33回生物無機化学夏季セミナー  2021.7 

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  • 抗酸化能を有する（ヘモグロビン‐アルブミン）クラスターの合成

    石丸真里花, 山田大雅, 小松晃之

    第33回生物無機化学夏季セミナー  2021.7 

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  • 人工ウイルス粒子捕集能を有するマイクロチューブモーターの合成【優秀ポスター賞受賞】

    明石勇志, 加藤 遼, 小松晃之

    第33回生物無機化学夏季セミナー  2021.7 

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  • 協同性を保持した（ヘモグロビン-アルブミン）トリマーの合成と酸素親和性制御

    高田諒也, 森田能次, 小松晃之

    第33回生物無機化学夏季セミナー  2021.7 

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  • 金属配位結合で連結した組換えヘモグロビンナノファイバーの合成

    澤口玲実, 森田能次, 小松晃之

    第33回生物無機化学夏季セミナー  2021.7 

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  • 自己攪拌型α-グルコシターゼマイクロチューブモーターの合成

    梅原瑞希, 加藤 遼, 森田能次, 小松晃之

    第33回生物無機化学夏季セミナー  2021.7 

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  • 光照射で速度制御可能な金ナノ粒子被覆カタラーゼマイクロチューブモーター

    加藤 遼, 菅原智直, 森田能次, 小松晃之

    第70回高分子学会年次大会  2021.5 

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  • がん治療用光増感剤としてのプロトポルフィリンⅨ結合（ヘモグロビン-アルブミン）クラスターの合成【優秀ポスター賞受賞】

    山田大雅, 小松晃之

    第70回高分子学会年次大会  2021.5 

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  • 動物用血漿増量剤としてのポリオキサゾリン修飾アルブミンの合成【優秀ポスター賞受賞】

    岡本 航, 臼井朝音, 河野光智, 田口和明, 小松晃之

    第70回高分子学会年次大会  2021.5 

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  • 金ナノ粒子で被覆したカタラーゼマイクロチューブモーターの合成と光照射による速度制御

    菅原智直, 加藤 遼, 森田能次, 小松晃之

    日本化学会第101春季年会  2021.3 

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  • 協同的酸素結合能を有する（ヘモグロビン-アルブミン）トリマーの合成

    高田諒也, 森田能次, 小松晃之

    日本化学会第101春季年会  2021.3 

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  • Lys-α99置換ヘモグロビン変異体の合成と酸素親和性

    吉田瑠佳, 齊藤飛鳥, 森田能次, 小松晃之

    日本化学会第101春季年会  2021.3 

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  • ポリオキサゾリン修飾ブタ血清アルブミンの合成

    臼井朝音, 岡本 航, 森田能次, 河野光智, 小松晃之

    日本化学会第101春季年会  2021.3 

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  • 組換えヒトヘモグロビンナノ粒子の合成と酸素結合能

    小林樹広, 岡本 航, 長谷川舞, 森田能次, 小松晃之

    日本化学会第101春季年会  2021.3 

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  • 蛋白質を用いた機能分子システムの創製と応用（依頼講演） Invited

    小松晃之

    日本化学会第101春季年会  2021.3 

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  • ヘモグロビンナノ粒子（HbNP）の合成と有効性評価

    長谷川舞, 岡本 航, 橋本 諒, 小野沢博登, 河野光智, 岩﨑正之, 小松晃之

    第27回日本血液代替物学会年次大会  2020.12 

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  • ポリオキサゾリン修飾ヘモグロビン（Hemoxa）の合成と有効性評価

    樋渡侑樹, 岡本 航, 橋本 諒, 小野沢博登, 河野光智, 岩﨑正之, 森田能次, 小松晃之

    第27回日本血液代替物学会年次大会  2020.12 

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  • 修飾ヘモグロビンおよび組換えヘモグロビンを用いた人工酸素運搬体製剤の開発（依頼講演） Invited

    小松晃之

    第27回日本血液代替物学会年次大会  2020.12 

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  • 出血性ショックラットを用いたHemoActの有効性評価（依頼講演）【学生講演賞受賞】 Invited

    岡本 航, 鹿島知周, 濱野辰彦, 橋本 諒, 小野沢博登, 河野光智, 岩﨑正之, 小松晃之

    第27回日本血液代替物学会年次大会  2020.12 

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  • 脳梗塞治療薬としてのHemoActの有効性（依頼講演） Invited

    鐙谷武雄, 月花正幸, 伊藤康裕, 小松晃之

    第27回日本血液代替物学会年次大会  2020.12 

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  • アロステリック効果を有する組換えヘモグロビン-アルブミントリマーの合成（依頼講演） Invited

    森田能次, 高田諒也, 齊藤飛鳥, 小松晃之

    第27回日本血液代替物学会年次大会  2020.12 

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  • アロステリック効果を有する組換えヘモグロビン-アルブミントリマーの合成 Invited

    森田能次, 高田諒也, 齊藤飛鳥, 小松晃之

    第27回日本血液代替物学会年次大会  2020.12 

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  • 脳梗塞治療薬としてのHemoActの有効性 Invited

    鐙谷武雄, 月花正幸, 伊藤康裕, 小松晃之

    第27回日本血液代替物学会年次大会  2020.12 

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  • 出血性ショックラットを用いたHemoActの有効性評価【優秀講演賞受賞】 Invited

    岡本 航, 鹿島知周, 濱野辰彦, 橋本 諒, 小野沢博登, 河野光智, 岩﨑正之, 小松晃之

    第27回日本血液代替物学会年次大会  2020.12 

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  • 修飾ヘモグロビンおよび組換えヘモグロビンを用いた人工酸素運搬体製剤の開発 Invited

    小松晃之

    第27回日本血液代替物学会年次大会  2020.12 

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  • ヒト用および動物用人工酸素運搬体製剤の開発（招待講演） Invited

    小松晃之

    JACIライフサイエンス技術部会  2020.11 

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  • 人工酸素運搬体（赤血球代替物）の開発（招待講演） Invited

    小松晃之

    CBI学会2020大会  2020.10 

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  • 人工酸素運搬体“ポリオキサゾリン修飾ヘモグロビン”の合成と有効性

    岡本 航, 樋渡侑樹, 森田能次, 河野光智, 小松晃之

    第10回CSJ化学フェスタ2020  2020.10 

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  • アゾベンゼン-ポリアクリル酸で被覆した蛋白質マイクロチューブモーターの合成とシクロデキストリン捕捉

    内藤圭吾, 加藤 遼, 森田能次, 小松晃之

    第10回CSJ化学フェスタ2020  2020.10 

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  • 赤血球と同等の酸素結合能を有する人工酸素運搬体“(ヘモグロビン-アルブミン)トリマー”の合成

    高田諒也, 齊藤飛鳥, 森田能次, 小松晃之

    第10回CSJ化学フェスタ2020  2020.10 

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  • 自己攪拌型酵素マイクロチューブモーターの合成

    梅原瑞希, 加藤 遼, 森田能次, 小松晃之

    第10回CSJ化学フェスタ2020  2020.10 

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  • 赤血球と同じ酸素輸送能を有する(ヘモグロビン-アルブミン)トリマーの合成

    齊藤飛鳥, 高田諒也, 森田能次, 小松晃之

    錯体化学会第70回討論会  2020.9 

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  • ビスターピリジン鉄錯体で連結したヘモグロビンナノファイバーの合成

    澤口玲実, 森田能次, 小松晃之

    錯体化学会第70回討論会  2020.9 

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  • 人工酸素運搬体としてのアルブミン-ヘモグロビンナノ粒子の合成

    岡本 航, 長谷川舞, 森田能次, 小松晃之

    第69回高分子学会年次大会  2020.5 

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  • ポリオキサゾリンで被覆したヘモグロビンの合成と酸素結合能

    樋渡侑樹, 岡本 航, 森田能次, 小松晃之

    日本化学会第100春季年会  2020.3 

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  • ヘモグロビンナノ粒子の合成と酸素結合能

    長谷川舞, 岡本 航, 森田能次, 小松晃之

    日本化学会第100春季年会  2020.3 

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  • ビスターピリジン鉄錯体で連結した組換えヘモグロビンナノファイバーの合成

    澤口玲実, 高橋大輝, 森田能次, 小松晃之

    日本化学会第100春季年会  2020.3 

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  • 変異導入による（組換えヘモグロビンーアルブミン）トリマーの酸素親和性制御

    高田諒也, 齊藤飛鳥, 森田能次, 小松晃之

    日本化学会第100春季年会  2020.3 

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  • 変異導入による(組換えヘモグロビン-アルブミン)トリマーの酸素親和性制御

    高田諒也, 齊藤飛鳥, 森田能次, 小松晃之

    日本化学会第100春季年会  2020.3 

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  • 化学修飾による(組換えヘモグロビン-アルブミン)トリマーの酸素親和性制御

    齊藤飛鳥, 森田能次, 小松 晃之

    日本化学会第100春季年会  2020.3 

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  • ポリアクリル酸で被覆した蛋白質マイクロチューブモーターの合成と機能

    内藤圭吾, 菅井夏穂, 森田能次, 小松晃之

    日本化学会第100春季年会  2020.3 

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  • 自己攪拌能を有するα-グルコシターゼマイクロチューブモーターの合成

    梅原瑞希, 菅井夏穂, 森田能次, 小松晃之

    日本化学会第100春季年会  2020.3 

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  • Hemoglobin-Albumin Cluster ”HemoAct™” as Red Blood Cell Substitute and O2 Therapeutic Invited

    T. Komatsu

    The 17th International Symposium on Blood Substitutes & Oxygen Therapeutics (XVII-ISBS-2019)  2019.11 

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  • Recombinant Hemoglobin-Albumin Cluster “HemoAct™” as an Entirely Synthetic O2 Carrier【Excelent Abstract Award】

    R. Funaki, W. Okamoto, C. Endo, Y. Morita, T. Komatsu

    The 17th International Symposium on Blood Substitutes & Oxygen Therapeutics (XVII-ISBS-2019)  2019.11 

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  • Efficient Synthesis Procedure of Hemoglobin-Albumin Cluster “HemoAct™”

    T. Hamano, S. Sakata, R. Funaki, Y. Morita, T. Komatsu

    The 17th International Symposium on Blood Substitutes & Oxygen Therapeutics (XVII-ISBS-2019)  2019.11 

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  • Synthesis and Oxygen Binding Property of Hemoglobin (βC93A)-Albumin Cluster “HemoAct™” with Allosteric Effect of Inositol Hexaphosphate

    Y. Morita, T. Komatsu

    The 17th International Symposium on Blood Substitutes & Oxygen Therapeutics (XVII-ISBS-2019)  2019.11 

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  • Hemoglobin-Albumin Cluster “HemoAct™” for Resuscitation from Hemorrhagic Shock in Rats

    W. Okamoto, T. Kashima, H. Onozawa, R. Hashinoto, M. Kohno, M. Iwazaki, T. Komatsu

    The 17th International Symposium on Blood Substitutes & Oxygen Therapeutics (XVII-ISBS-2019)  2019.11 

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  • アロステリック効果を有する(ヘモグロビン(βK120C)-アルブミン)トリマーの合成と酸素結合パラメーター

    齊藤飛鳥, 森田能次, 小松晃之

    第９回CSJ化学フェスタ2019  2019.10 

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  • 大腸菌捕捉能を有するレクチン/カタラーゼマイクロチューブモーターの合成

    菅井夏穂, 森田能次, 小松晃之

    第９回CSJ化学フェスタ2019  2019.10 

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  • 大腸菌捕捉能を有するレクチン/カタラーゼマイクロチューブモーターの合成

    菅井夏穂, 森田能次, 小松晃之

    第９回CSJ化学フェスタ2019  2019.10 

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  • ビスマレイミド架橋剤で連結したヘモグロビンオリゴマーの合成と酸素結合能

    高橋大輝, 森田能次, 小松晃之

    第68回高分子討論会  2019.9 

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  • バクテリア捕集能を有するカタラーゼマイクロチューブモータの合成

    菅井夏穂, 森田能次, 小松晃之

    第68回高分子討論会  2019.9 

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  • (遠位アミノ酸置換ヘモグロビン-アルブミン)クラスターの合成と酸素結合能

    岡本 航, 遠藤千尋, 船木亮佑, 森田能次, 小松晃之

    錯体化学会第69回討論会  2019.9 

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  • 協同性を保持した(ヘモグロビン(βK120C)-アルブミン)トリマーの合成と酸素結合能

    齊藤飛鳥, 森田能次, 小松晃之

    錯体化学会第69回討論会  2019.9 

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  • Hemoglobin-Albumin Cluster as Red Blood Cell Substitute International conference

    T. Komatsu

    International Conference on Materials Science and Engineering (Materials Oceania)  2019.9 

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  • Synthesis of Catalase Microtube Motors with Controllable Velocity and Biodegradability【ポスター賞受賞】 International conference

    N. Sugai, T. Komatsu

    International Conference on Materials Science and Engineering (Materials Oceania)  2019.9 

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  • Synthesis and Drug Binding Properties of Recombinant Canine Serum Albumin International conference

    T. Hasegawa, Y. Morita, T. Komatsu

    International Conference on Materials Science and Engineering (Materials Oceania)  2019.9 

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  • 協同的酸素結合能を有する(ヘモグロビン-アルブミン)トリマーの合成

    森田能次, 齊藤飛鳥, 小松晃之

    第13回バイオ関連化学シンポジウム2019  2019.9 

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  • Self-Propelled Microtube Motors Consisting only of Proteins（招待講演） Invited

    T. Komatsu

    The 12th East Asian Symposium on Polymers for Advanced Technology (EASPAT 2017)  2019.6 

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  • Self-Propelled Microtube Motors（招待講演） Invited

    T. Komatsu

    IUPAC 18th International Symposium on MacroMolecular Complexes (MMC-18)  2019.6 

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  • 遠位アミノ酸を置換した組換え(ヘモグロビン-アルブミン)クラスターの合成と酸素親和性

    遠藤千尋, 船木亮佑, 森田能次, 小松晃之

    第68回高分子学会年次大会  2019.5 

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  • ポリオキサゾリン修飾ヘモグロビンの合成および酸素結合能

    樋渡佑樹, 森田能次, 小松晃之

    第68回高分子学会年次大会  2019.5 

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  • ビスマレイミド架橋剤を用いたヘモグロビン重合体の合成

    高橋大輝, 森田能次, 小松晃之

    日本化学会第99春季年会  2019.3 

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  • 外表面をアビジンで被覆した蛋白質マイクロチューブモーターの合成と機能

    菅井夏穂, 中井葉子, 森田能次, 小松晃之

    日本化学会第99春季年会  2019.3 

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  • Synthesis and Oxygen Affinity of Hemoglobin(βC93A)-Albumin Cluster

    Y. Morita, K. Igarashi, T. Komatsu

    日本化学会第99春季年会  2019.3 

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  • (ヘモグロビン(βL28変異体)-アルブミン)クラスターの合成と酸素結合能

    岡本 航, 船木亮佑, 森田能次, 小松晃之

    日本化学会第99春季年会  2019.3 

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  • (ヘモグロビン(βK120C)-アルブミン)トリマーの合成

    齊藤飛鳥, 森田能次, 小松晃之

    日本化学会第99春季年会  2019.3 

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  • 人工酸素運搬体(ヒトヘモグロビン-アルブミン)クラスターの調製

    濱野辰彦, 坂田 翔, 鹿島知周, 船木亮佑, 森田能次, 小松晃之

    日本化学会第99春季年会  2019.3 

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  • Synthesis and Ligand-Binding Property of Myoglobin-Albumin Cluster International conference

    T. Anekawa, Y. Morita, T. Komatsu

    IUPAC 14th International Conference on Novel Materials and their Synthesis (NMS-XIV)  2018.10 

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  • Gold-Nanoparticle Nanotubes Loaded Liposomes Encapsulating Anticancer Drug Doxorubicin International conference

    Y. Enomoto, Y. Morita, T. Komatsu

    IUPAC 14th International Conference on Novel Materials and their Synthesis (NMS-XIV)  2018.10 

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  • Self-Propelled Soft Protein Microtubes（招待講演） Invited International conference

    T. Komatsu

    IUPAC 14th International Conference on Novel Materials and their Synthesis (NMS-XIV)  2018.10 

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  • (酵素-アルブミン)クラスターの合成と酵素活性

    市原聖人, 森田能次, 小松晃之

    第25回日本血液代替物学会年次大会  2018.10 

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  • アロステリック因子で酸素親和性を調節できる組換え(ヘモグロビン(C93A(β))-アルブミン)クラスターの合成

    五十嵐啓介, 森田能次, 小松晃之

    第25回日本血液代替物学会年次大会  2018.10 

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  • ラット出血性ショックモデルを用いたHemoActの有効性評価

    鹿島知周, 市原聖人, 岡本 航, 小野沢博登, 河野光智, 岩﨑正之, 小松晃之

    第25回日本血液代替物学会年次大会  2018.10 

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  • Modulation of O2-Binding Affinity of Hemoglobin-Albumin Cluster as an Artificial O2 Carrier

    Y. Morita, T. Yamada, T. Komatsu

    43rd International Conference on Coordination Chemistry (ICCC 2018)  2018.8 

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  • Synthesis and O2-Binding Property of Recombinant(Hemoglobin-Albumin) Cluster

    R. Funaki, W. Okamoto, Y. Morita, T. Komatsu

    43rd International Conference on Coordination Chemistry (ICCC 2018)  2018.8 

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  • 組換え(ヘモグロビン(βC93A)-アルブミン)クラスターの合成と酸素結合能【ポスター賞受賞】

    五十嵐啓介, 森田能次, 小松晃之

    錯体化学会第68回討論会  2018.7 

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  • 水中で自走するカタラーゼマイクロチューブの合成【ポスター賞受賞】

    菅井夏穂, 中井葉子, 森田能次, 小松晃之

    第67回高分子学会年次大会  2018.5 

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  • （ヘモグロビン-アルブミン）クラスター含有ハイドロゲルの合成と酸素結合能

    鹿島知則, 長田一暉, 森田能次, 小松晃之

    第67回高分子学会年次大会  2018.5 

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  • 人工酸素運搬体：組換え（ヘモグロビン‐アルブミン）クラスターの合成

    船木亮佑, 岡本 航, 森田能次, 小松晃之

    第67回高分子学会年次大会  2018.5 

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  • 水中で自走するカタラーゼマイクロチューブの合成

    菅井夏穂, 中井葉子, 森田能次, 小松晃之

    第67回高分子学会年次大会  2018.5 

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  • Structure and Oxygen Binding Affinity of Hemoglobin-Albumin Cluster as an Artificial Oxygen Carrier

    Y. Morita, T. Yamada, T. Komatsu

    日本化学会第98春季年会  2018.3 

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  • 組換え（ヘモグロビン－アルブミン）クラスターの合成と酸素結合能

    岡本 航, 船木亮佑, 森田能次, 小松晃之

    日本化学会第98春季年会  2018.3 

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  • （ミオグロビン－アルブミン）クラスターの合成と酸素・一酸化炭素結合能

    姉川拓海, 森田能次, 小松晃之

    日本化学会第98春季年会  2018.3 

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  • 人工酸素運搬体（ヘモグロビン－アルブミン）クラスターの調製

    坂田 翔, 船木亮佑, 森田能次, 小松晃之

    日本化学会第98春季年会  2018.3 

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  • リポソームを内包した金ナノ粒子ナノチューブの合成と薬物放出

    榎本由人, 森田能次, 小松晃之

    日本化学会第98春季年会  2018.3 

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  • 自走するカタラーゼマイクロチューブの合成とその速度制御

    菅井夏穂, 中井葉子, 森田能次, 小松晃之

    日本化学会第98春季年会  2018.3 

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  • 組換え蛋白質を用いた人工酸素運搬体「HemoAct™」の開発（依頼講演）

    小松晃之

    第24回日本血液代替物学会年次大会  2017.12 

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  • 脳梗塞治療薬としてのヘモアクト™の効果（依頼講演）

    鐙谷武雄, 月花正幸, 小松晃之, 船木亮佑, 川堀真人, 長内俊也, 中山若樹, 数又 研, 寳金清博

    第24回日本血液代替物学会年次大会  2017.12 

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  • 遺伝子組換えイヌおよびネコ血清アルブミンの開発と動物用人工酸素運搬体の展開（依頼講演）

    森田能次, 五十嵐啓介, 秋山元英, 木平清人, 小松晃之

    第24回日本血液代替物学会年次大会  2017.12 

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  • 遺伝子組換え（ヘモグロビン-アルブミン）クラスターの合成【学生講演賞受賞】

    船木亮佑, 秋山元英, 森田能次, 小松晃之

    第24回日本血液代替物学会年次大会  2017.12 

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  • Hemoglobin-Albumin Cluster ”HemoAct” as an Artificial O2-Carrier

    T. Komatsu

    XVI International Symposium on Blood Substitutes & Oxygen Therapeutics (XVI ISBS)  2017.11 

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  • Protein-Based Smart Nano- and Micro-tubes（招待講演）

    T. Komatsu  2017.10 

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  • Efficient Preparation and O2-Binding Property of Hemoglobin-Albumin Cluster

    R. Funaki, T. Komatsu

    IUPAC 13th International Conference on Novel Materials and their Synthesis (NMS-XIII)  2017.10 

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  • 低酸素親和性（ヘモグロビン-アルブミン）クラスターの構造

    山田大雅, 森田能次, 小松晃之

    第７回CSJ化学フェスタ201７  2017.10 

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  • ビスターピリジン金属錯体で連結したヒト血清アルブミンナノワイヤーおよびナノチューブの合成【ポスター賞受賞】

    満田達也, 安達 諒, 森田能次

    第７回CSJ化学フェスタ201７、東京  2017.10 

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  • 人工酸素運搬体（ヘモグロビン-アルブミン）クラスターの開発（招待講演）

    小松晃之

    第30回生物無機化学夏季セミナー  2017.9 

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  • Protein Nano- and Micro-tubes as Functional Biomaterials

    T. Komatsu

    14th International Conference on Polymers for Advanced Technologies (PAT-2017)  2017.9 

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  • Exchange Transfusion with Red Blood Cell Substitute “Hemoglobin-Albumin Cluster

    M. Kureishi, H. Iwasaki, R. Hashimoto, M. Kohno, M. Iwazaki, T. Komatsu

    14th International Conference on Polymers for Advanced Technologies (PAT-2017)  2017.9 

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  • Self-Propelled Protein Microtubes with an Interior Surface Composed of Pt Nanoparticles

    Y. Nakai, Y. Morita, T. Komatsu

    14th International Conference on Polymers for Advanced Technologies (PAT-2017)  2017.9 

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  • Synthesis and O2-Binding Property of Cys-93(β) Substituted Intramolecular Crosslinked Hemoglobins

    K. Osadsa, Y. Morita, T. Komatsu

    14th International Conference on Polymers for Advanced Technologies (PAT-2017)  2017.9 

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  • ビスターピリジン金属錯体で連結したアルブミンナノワイヤーの合成

    安達 諒, 満田達也, 森田能次, 小松晃之

    錯体化学会第67回討論会  2017.9 

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  • 低酸素親和性（ヘモグロビン-アルブミン）クラスターの合成と構造

    山田大雅, 森田能次, 小松晃之

    錯体化学会第67回討論会  2017.9 

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  • アルブミン結合数の異なる（ヘモグロビン-アルブミン）クラスターの構造と酸素親和性

    鹿島知則, 山田大雅, 森田能次, 小松晃之

    錯体化学会第67回討論会  2017.9 

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  • 金属配位結合で連結したヒト血清アルブミンナノワイヤーおよびナノチューブの合成【ポスター賞受賞】

    満田達也, 安達 諒, 森田能次, 小松晃之

    第66回高分子討論会  2017.9 

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  • リポソームを内孔表面に固定した金ナノ粒子ナノチューブの合成

    榎本由人, 森田能次, 小松晃之

    第66回高分子討論会  2017.9 

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  • Hemoglobin-Albumin Clusters as Red Blood Cell Substitutes for Human Beings and Pet Animals（招待講演）

    T. Komatsu

    IUPAC 17th International Symposium on MacroMolecular Complexes (MMC-17)  2017.8 

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  • Cobalt Tetradehydrocorrin in a Myoglobin Matrix as an Enzyme Model of Methionine Synthase

    Y. Morita, T. Ohora, T. Hayashi, T. Komatsu

    IUPAC 17th International Symposium on MacroMolecular Complexes (MMC-17)  2017.8 

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  • Safety Evaluation of Hemoglobin-Albumin Cluster using 20% Exchange Transfusion Rat Model

    M. Kureishi, H. Iwasaki, R. Hashimoto, M. Kohno, M. Iwazaki, T. Komatsu

    UPAC 17th International Symposium on MacroMolecular Complexes (MMC-17)  2017.8 

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  • Self-Propelled Protein Microtube and its E.coli Capturing Ability【ポスター賞受賞】

    Y. Nakai, M. Akiyama, Y. Morita, T. Komatsu

    IUPAC 17th International Symposium on MacroMolecular Complexes (MMC-17)  2017.8 

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  • Molecular Structures of Artificial Blood for Dogs and Cats

    T. Komatsu, K. Kihira, K. Matsumoto

    International Space Station Research and Development Conference (ISS R&D)  2017.7 

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  • 人工酸素運搬体（赤血球代替物）の開発（招待講演）

    小松晃之

    日本獣医臨床病理学会2017年大会  2017.6 

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  • Hemoglobin-Albumin Clusters as Artificial O2-Carriers for Human Beings and Pet Animals（招待講演）

    T. Komatsu

    The 11th East Asian Symposium on Polymers for Advanced Technology (EASPAT 2017)  2017.6 

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  • アルブミン結合数の異なる（ヘモグロビン－組換えイヌ血清アルブミン）クラスターの合成と酸素結合能

    五十嵐啓介, 横幕恭子, 小松晃之

    日本化学会第97春季年会  2017.3 

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  • （ヘモグロビン－アルブミン）クラスターの酸素・一酸化炭素結合反応

    呉石萌佳, 小松晃之

    日本化学会第97春季年会  2017.3 

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  • アルブミン結合数の異なる（ヘモグロビン－アルブミン）クラスターの単離と酸素結合能

    鹿島知周, 山田大雅, 船木亮佑, 小松晃之

    日本化学会第97春季年会  2017.3 

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  • （ヒトヘモグロビン－アルブミン）クラスターの効率高い合成と酸素結合能評価

    姉川拓海, 船木亮佑, 小松晃之

    日本化学会第97春季年会  2017.3 

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  • アルブミン結合ββ架橋ヘモグロビンの合成と酸素結合能

    長田一暉, 小松晃之

    日本化学会第97春季年会  2017.3 

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  • （カタラーゼ-アルブミン）クラスターの合成と酵素活性

    市原聖人, 八木澤結香, 小松晃之

    日本化学会第97春季年会  2017.3 

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  • （ヘモグロビン-アルブミン）クラスターの酸素結合能と構造解析

    船木亮佑, 山田大雅, C. Boettche, 小松晃之

    第６回CSJ化学フェスタ2016  2016.11 

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  • 自走方向を制御できる蛋白質マイクロチューブの合成と大腸菌捕捉【ポスター賞受賞】

    中井葉子, 秋山元英, 小松晃之

    第６回CSJ化学フェスタ2016  2016.11 

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  • イヌ用・ネコ用人工酸素運搬体（HemoAct-C™、HemoAct-F™）の開発

    横幕恭子, 呉石萌佳, 秋山元英, 木平清人, 小松晃之

    第23回日本血液代替物学会年次大会  2016.11 

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  • ラット20％血液交換モデルを用いたHemoAct™の安全性評価

    岩崎 瞳, 呉石萌佳, 橋本 諒, 河野光智, 岩崎正之, 小松晃之

    第23回日本血液代替物学会年次大会  2016.11 

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  • がん治療用光増感剤としてのアルブミン-金属ポルフィリン錯体の開発（依頼講演）

    秋山元英, 小松晃之

    第23回日本血液代替物学会年次大会  2016.11 

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  • Core-Shell Structured Hemoglobin-Albumin Cluster Designed for Use as a Red Blood Cell Substitute（招待講演）

    T. Komatsu

    IUPAC 12th International Conference on Novel Materials and their Synthesis (NMS-XII)  2016.10 

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  • 3D-Structure and O2-Binding Property of Hemoglobin-Albumin Cluster

    R. Funaki, T. Yamada, C. Böttcher, T. Komatsu

    IUPAC 12th International Conference on Novel Materials and their Synthesis (NMS-XII)  2016.10 

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  • Hemoglobin-Recombinant Canine Serum Albumin Cluster as an Artificial Blood for Dogs【ポスター賞受賞】

    K. Yokomaku, M. Kureishi, M. Akiyama, T. Komatsu

    IUPAC 12th International Conference on Novel Materials and their Synthesis (NMS-XII)  2016.10 

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  • Exchange Transfusion with Hemoglobin-Albumin Cluster into Rats: Physiological Responses and Blood Biochemical Tests

    H. Iwasaki, M. Kureishi, R. Hashimoto, M. Kohono, M. Iwazaki, T. Komatsu

    IUPAC 12th International Conference on Novel Materials and their Synthesis (NMS-XII)  2016.10 

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  • DNAナノチューブの薬物送達システムへの応用

    山田知佳, 秋山元英, 小松晃之

    第10回バイオ関連化学シンポジウム  2016.9 

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  • グルコースオキシダーゼマイクロチューブの酵素活性

    安達 諒, 秋山元英, 小松晃之

    第10回バイオ関連化学シンポジウム  2016.9 

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  • 鋳型内交互積層法によるDNAナノチューブの合成とその応用

    秋山元英, 山田知佳, 小松晃之

    第10回バイオ関連化学シンポジウム  2016.9 

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  • （カタラーゼ-アルブミン）クラスターの合成と過酸化水素分解能

    八木澤結香, 小松晃之

    錯体化学会第66回討論会  2016.9 

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  • （ヘモグロビン-アルブミン）クラスターの酸素親和性制御

    山田大雅, 小松晃之

    錯体化学会第66回討論会  2016.9 

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  • ポリ（エチレングリコール）結合ββ架橋ヘモグロビンの構造と酸素配位

    長田一暉, 小松晃之

    錯体化学会第66回討論会  2016.9 

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  • 人工酸素運搬体（赤血球代替物）の開発（招待講演）

    回ペプチド夏の勉強会

    小松晃之  2016.7 

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  • 自走する蛋白質マイクロチューブの大腸菌捕捉能

    中井葉子, 小早川聡志, 秋山元英, 小松晃之

    第65回高分子学会年次大会  2016.5 

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  • 人工酸素運搬体としての（ヘモグロビン-組換えイヌ血清アルブミン）クラスターの合成

    呉石萌佳, 山田佳奈, 横幕恭子, 秋山元英, 小松晃之

    第65回高分子学会年次大会  2016.5 

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  • 人工酸素運搬体としてのヒト（ヘモグロビン-アルブミン）クラスターの特徴

    岩崎 瞳, 小松晃之

    日本化学会第96春季年会  2016.3 

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  • （ヘモグロビン-遺伝子組換えイヌ血清アルブミン）クラスターの合成と酸素結合能

    呉石萌佳, 山田佳奈, 秋山元英, 小松晃之

    日本化学会第96春季年会  2016.3 

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  • グルコースオキシダーゼを階層成分として有する蛋白質マイクロチューブの合成

    安達 諒, 秋山元英, 小松晃之

    日本化学会第96春季年会  2016.3 

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  • 自走する蛋白質マイクロチューブの合成とその大腸菌捕捉能

    中井葉子, 小早川聡史, 秋山元英, 小松晃之

    日本化学会第96春季年会  2016.3 

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  • （ヘモグロビン-組換えネコ血清アルブミン）クラスターの合成と酸素結合能

    横幕恭子, 小松晃之

    日本化学会第96春季年会  2016.3 

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  • （ヘモグロビン-ウシ血清アルブミン）クラスターの合成と酸素結合能

    山田大雅, 篠原隆一, 小松晃之

    日本化学会第96春季年会  2016.3 

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  • ポリ（エチレングリコール）を結合した分子内架橋ヘモグロビンの合成と酸素結合能

    長田一暉, 篠原隆一, 小松晃之

    日本化学会第96春季年会  2016.3 

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  • 人工酸素運搬体としての（ヘモグロビン-アルブミン）クラスターの分離精製法

    船木亮佑, 秋山元英, 小松晃之

    日本化学会第96春季年会  2016.3 

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  • Photodynamic Activities of Human Serum Albumin-Metalloporphyrin Complex

    M. Akiyama, T. Komatsu

    The International Chemical Congress of Pacific Basin Societies (Pacifichem 2015)  2015.12 

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  • Synthesis of Self-Propelled Protein Microtubes

    S. Kobayakawa, T. Komatsu

    The International Chemical Congress of Pacific Basin Societies (Pacifichem 2015)  2015.12 

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  • Human(Hemoglobin-Albumin)Clusters Having Various O2-Affniities

    R. Shinohara, T. Komatsu

    The International Chemical Congress of Pacific Basin Societies (Pacifichem 2015)  2015.12 

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  • Synthesis of Human Serum Albumin Having a Terpyridyl Group and Its Dimer Formation by Metal Ion Coordination

    S. Suzuki, T. Komatsu

    The International Chemical Congress of Pacific Basin Societies (Pacifichem 2015)  2015.12 

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  • Synthesis and Property of Recombinant Canine Serum Albumin

    K. Yamada, R. Yoneyama, T. Komatsu

    The International Chemical Congress of Pacific Basin Societies (Pacifichem 2015)  2015.12 

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  • O2-Affinity and Safety of Hemoglobin-Albumin Cluster

    H. Iwasaki, R. Haruki, T. Komatsu

    The International Chemical Congress of Pacific Basin Societies (Pacifichem 2015)  2015.12 

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  • Efficient Synthesis of Hemoglobin-Albumin Cluster

    R. Funaki, M. Akiyama, T. Komatsu

    International Chemical Congress of Pacific Basin Societies (Pacifichem 2015)  2015.12 

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  • Synthesis of Porphyrin Wire Connected by Pd Coordination

    Y. Yagisawa, Y. Yamazawa, T. Komatsu

    The International Chemical Congress of Pacific Basin Societies (Pacifichem 2015)  2015.12 

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  • Synthesis and Anticancer Activity of Doxrobicin-Loaded DNA Nanotubes

    C. Yamada, M. Akiyama, T. Komatsu

    The International Chemical Congress of Pacific Basin Societies (Pacifichem 2015)v  2015.12 

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  • Hemoglobin-Albumin Clusters Having Different Mammalian Hemoglobin

    K. Yokomaku, R. Shinohara, T. Komatsu

    The International Chemical Congress of Pacific Basin Societies (Pacifichem 2015)  2015.12 

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  • （ヘモグロビン-イヌアルブミン）クラスターの合成と酸素結合能

    山田佳奈, 秋山元英, 小松晃之

    第5回CSJ化学フェスタ2015  2015.10 

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  • ドキソルビシンを導入したDNAナノチューブの合成と抗がん活性

    山田知佳, 秋山元英, 小松晃之

    第5回CSJ化学フェスタ2015  2015.10 

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  • 人工酸素運搬体“HemoAct™”の実用化に向けた研究展開（依頼講演）

    小松晃之

    第22回日本血液代替物学会年次大会  2015.10 

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  • イヌ用人工血液の開発（依頼講演）【学生講演賞受賞】

    山田佳奈, 秋山元英, 小松晃之

    第22回日本血液代替物学会年次大会  2015.10 

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  • HemoAct™の効率高い精製と酸素親和性測定

    岩崎 瞳, 船木亮佑, 小松晃之

    第22回日本血液代替物学会年次大会  2015.10 

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  • ブタヘモグロビンを用いたHemoAct™の合成と酸素結合能

    横幕恭子, 小松晃之

    第22回日本血液代替物学会年次大会  2015.10 

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  • Hemoglobin-Albumin Clusters as Red Blood Cell Substitutes（招待講演）

    T. Komatsu

    11th IUPAC International Conference on Novel Materials and their Synthesis (NMS-XI)  2015.10 

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  • Pd配位で連結したポルフィリンワイヤーの合成

    八木澤結香, 山澤幸香, 秋山元英, 小松晃之

    錯体化学会第65回討論会  2015.9 

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  • ヒト血清アルブミン-金属ポルフィリン錯体の光増感能と抗がん活性

    秋山元英, 服部周悟, 小松晃之

    錯体化学会第65回討論会  2015.9 

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  • Hemoglobin-Albumin Cluster as a Potential O2-Carrier Designed for Red Blood Cell Substitute

    T. Komatsu

    IUPAC 16th International Symposium on MacroMolecular Complexes (MMC-16)  2015.8 

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  • Hemoglobin-Albumin Cluster as a Potential O2-Carrier for Red Blood Cell Substitute (招待講演)

    T. Komatsu

    East Asian Symposium on Polymers for Advanced Technology (EASPAT 2015)  2015.7 

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  • Protein Nano- and Micro-tubes as Smart Biomaterials (招待講演)

    T. Komatsu

    IMS Asian International Symposium "Supramolecular Dynamics at the Interface of Chemistry and Biology"  2015.6 

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  • ターピリジル基を有するヒト血清アルブミンの合成と配位結合を介した二量体形成

    鈴木駿, 早川瑛庸, 小松晃之

    日本化学会第95春季年会  2015.3 

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  • 自走する蛋白質マイクロチューブの合成

    小早川聡史, 小松晃之

    日本化学会第95春季年会  2015.3 

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  • ドキソルビシンを導入したDNAナノチューブの合成と抗癌活性

    山田知佳, 秋山元英, 小松晃之

    日本化学会第95春季年会  2015.3 

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  • （ヘモグロビン-アルブミン）クラスターの酸素親和性と安全性

    岩崎 瞳, 篠原隆一, 春木理沙, 神山育男, 河野光智, 小松晃之

    日本化学会第95春季年会  2015.3 

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  • HemoAct™の血液適合性及び安全性（依頼講演）（学生講演賞受賞）

    春木理沙, 神山育男, 松田信作, 河野光智, 田口和明, 永尾紗理, 丸山 徹, 小田切優樹, 小松晃之

    第21回日本血液代替物学会年次大会  2014.12 

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  • 人工酸素運搬体HemoAct™の開発（大会長講演）

    小松晃之

    第21回日本血液代替物学会年次大会  2014.12 

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  • ヘモグロビン-アルブミン）クラスター“HemoAct™”の分子構造調節

    山田佳奈, 春木理沙, 田口和明, 永尾紗理, 丸山徹, 小田切優樹, 小松晃之

    第21回日本血液代替物学会年次大会  2014.12 

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  • Protein Nanotubes as Smart Biomaterials (招待講演)

    T. Komtasu

    10th IUPAC International Conference on Novel Materials and their Synthesis (NMS-X)  2014.10 

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  • Solution Property and Blood Compatibility of Hemoglobin-Albumin Cluster “HemoAct™”

    R. Haruki, M. Kamiyama, M. Kohno, T. Komtasu

    10th IUPAC International Conference on Novel Materials and their Synthesis (NMS-X)  2014.10 

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  • Synthesis and O2 Binding Property of Human(Hemoglobin-Albumin) Cluster

    R. Shinohara, T. Komtasu

    10th IUPAC International Conference on Novel Materials and their Synthesis (NMS-X)  2014.10 

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  • (Cross-Linked Hemoglobin)-Albumin Cluster as an Artificial O2 Carrier (ポスター賞受賞)

    K. Yamada, T. Komtasu

    10th IUPAC International Conference on Novel Materials and their Synthesis (NMS-X)  2014.10 

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  • H2O2不均化能を付与した（ヘモグロビン-アルブミン）クラスターの合成

    代島雄太, 小松晃之

    第64回錯体化学討論会  2014.9 

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  • テトラキス（ニコチノイルアミノ）金属錯体キャップ型ポルフィリンの合成

    山澤幸香, 小松晃之

    第64回錯体化学討論会  2014.9 

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  • 水酸基を有するテトラフェニルポルフィリンの有機リン系農薬添加による吸光度変化と錯形成反応の解析

    村上貴哉, 岩室嘉晃, 地中啓, 高山成明, 小松晃之

    日本分析化学会第63年会  2014.9 

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  • タンパク質を用いた機能分子・材料の創製‒人工血液からナノチューブまで‒（依頼講演）

    小松晃之

    東京理科大学総合研究機構「分子連関相乗系研究部門」セミナー  2014.7 

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  • ターピリジル基を有するヒト血清アルブミンの合成と金属イオン配位による二量体形成

    鈴木 駿, 石川夏樹, 小松晃之

    第63回高分子学会年次大会  2014.5 

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  • マンガンポルフィリンを結合した(ヘモグロビン-アルブミン）クラスターの合成

    代島雄汰, 小松晃之

    第63回高分子学会年次大会  2014.5 

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  • 大腸菌捕捉能を有する蛋白質マイクロチューブ

    弓削秀太, 秋山元英, 小松晃之

    第63回高分子学会年次大会  2014.5 

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  • 白金ナノ粒子内包アポフェリチンからなるナノチューブの合成と過酸化水素分解能

    小早川聡史, 佐々木匠, 小松晃之

    日本化学会第94春季年会  2014.3 

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  • ヒト血清アルブミン-金属ポルフィリン錯体の光線力学活性とその作用機序

    秋山元英, 服部周悟, 小松晃之

    日本化学会第94春季年会  2014.3 

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  • アルブミン結合数の異なる（ヘモグロビン-アルブミン）クラスターの合成と特徴

    山田佳奈, 木村拓矢, 小松晃之

    日本化学会第94春季年会  2014.3 

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  • ヒト（ヘモグロビン-アルブミン）クラスターの合成と酸素配位

    篠原隆一, 木村拓矢, 小松晃之

    日本化学会第94春季年会  2014.3 

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  • Core-Shell Architecture of Hemoglobin and Human Serum Albumin as an Artificial O2 Carrier（招待講演）

    T. Komatsu

    International Symposium on Coordination Programming 2014  2014.1 

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  • Photodynamic Activities of Human Serum Albumin-Zn(II)protoporphyrin IX Complex

    M. Akiyama, T. Komatsu

    International Symposium on Coordination Programming 2014  2014.1 

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  • ヒト（ヘモグロビン-アルブミン）クラスターの合成と酸素結合能

    木村拓矢, 小松晃之

    第20回日本血液代替物学会年次大会  2013.12 

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  • （ヘモグロビン-アルブミン）クラスターの溶液物性と血液適合性

    春木理沙, 木村拓矢, 神山育男, 河野光智, 小松晃之

    第20回日本血液代替物学会年次大会  2013.12 

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  • ヒト血清アルブミン-金属ポルフィリン錯体の光増感剤とがん細胞殺傷能

    服部周悟, 秋山元英, 小松晃之

    第63回錯体化学討論会  2013.11 

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  • 白金ナノ粒子内包アポフェリチンを用いたナノチューブの合成と触媒活性

    佐々木匠, 小松晃之

    第63回錯体化学討論会  2013.11 

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  • 抗酸化能を付与した（ヘモグロビン-アルブミン）クラスターの合成と酸素結合能

    保坂仁美, 小松晃之

    第63回錯体化学討論会  2013.11 

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  • 酸素輸送ヘム蛋白質（ヘモグロビン-アルブミン）クラスターの合成と物性評価

    春木理沙, 木村拓矢, 河野光智, 小松晃之

    第63回錯体化学討論会  2013.11 

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  • パラジウム錯体キャップ型ポルフィリンの合成と特徴

    山澤幸香, 小松晃之

    第63回錯体化学討論会  2013.11 

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  • Protein-Based Smart Nanotubes for Biomedical Applications（招待講演）

    T. Komatsu

    East Asian Symposium on Polymers for Advanced Technology  2013.10 

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  • Protein Nanotubes for Biomedical Applications（招待講演）

    T. Komatsu

    12th International Conference on Polymers for Advanced Technologies  2013.9 

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  • E.coli Trap in Human Serum Albumin Microtube

    Shuta Yuge, Motofusa Akiyama, T. Komatsu

    12th International Conference on Polymers for Advanced Technologies  2013.9 

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  • Photodynamic Activities of Human Serum Albumin-Zn(II)protoporphyrin IX Complex

    Motofusa Akiyama, Shugo Hattori, T. Komatsu

    12th International Conference on Polymers for Advanced Technologies  2013.9 

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  • Protein Nanotubes for Biomedical and Catalytic Applications（招待講演）

    T. Komatsu

    IUPAC 15th International Symposium on MacroMolecular Complexes  2013.8 

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  • Core-Shell Structured Protein Cluster of Hemoglobin and Human Serum Albumin as an Artificial O2-Carrier（ポスター賞受賞）

    Takuya Kimura, Daiki Tomita, T. Komatsu

    IUPAC 15th International Symposium on MacroMolecular Complexes  2013.8 

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  • Protein Nanotube for Ring-Opening Polymerization of Lactone

    Yusuke Amano, T. Komatsu

    IUPAC 15th International Symposium on MacroMolecular Complexes  2013.8 

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  • Preparation and Oxygen-Affinity of Hemoglobin-Albumin Cluster

    T. Kimura, R. Haruki, T. Fushimi, T. Komatsu

    第62回高分子学会年次大会  2013.5 

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  • ビリルビンを結合した（ヘモグロビン-アルブミン）クラスターの合成と特徴

    保坂仁美, 冨田大樹, 小松晃之

    日本化学会第93春季年会  2013.3 

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  • フラビンを結合した（ヘモグロビン-アルブミン）クラスターの合成とヘム還元反応

    代島雄汰, 冨田大樹, 小松晃之

    日本化学会第93春季年会  2013.3 

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  • （ヘモグロビン-アルブミン）クラスターの調製と血液適合性

    春木理沙, 木村拓矢, 冨田大樹, 宗慶太郎, 小松晃之

    日本化学会第93春季年会  2013.3 

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  • 蛋白質マイクロチューブの合成と大腸菌捕捉

    弓削秀太, 秋山元英, 後藤峻, 小松晃之

    日本化学会第93春季年会  2013.3 

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  • 4つのニコチノイル基を有するポルフィリンの合成と金属配位

    山澤幸香, 粕谷咲子, 小松晃之

    日本化学会第93春季年会  2013.3 

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  • ヒト血清アルブミン-Zn(II)ポルフィリン錯体の光線力学活性とその作用機構

    秋山元英, 杉浦侑, 小松晃之

    日本化学会第93春季年会  2013.3 

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  • 蛋白質超構造体を用いた医用分子・材料の創製（依頼講演）

    小松晃之

    12-2超分子研究会  2013.1 

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  • 人工ヘム蛋白質（ヘモグロビン-アルブミン）クラスターの開発

    冨田大樹, 木村拓矢, 小松晃之

    第19回日本血液代替物学会年次大会  2012.10 

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  • 人工酸素運搬体（ヘモグロビン-アルブミン）クラスターの酸素結合能

    木村拓矢, 冨田大樹, 小松晃之

    第61回高分子討論会  2012.9 

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  • ヒト血清アルブミン-Zn(II)プロトポルフィリン錯体の光線力学活性

    秋山元英, 小松晃之

    第61回高分子討論会  2012.9 

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  • 酸素輸送ヘム蛋白質：（ヘモグロビン-アルブミン）クラスター（ポスター賞受章）

    冨田大樹, 木村拓矢, 小松晃之

    第62回錯体化学討論会  2012.9 

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  • 組換えアルブミン-マンガンポルフィリン錯体のSOD活性

    加藤竜之介, 小松晃之

    第62回錯体化学討論会  2012.9 

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  • 組換えアルブミン-鉄ポルフィリン錯体のペルオキシダーゼ活性

    石川夏樹, 小松晃之

    第62回錯体化学討論会  2012.9 

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  • 組換えアルブミン-マグネシウムポルフィリン錯体の合成と特徴

    服部周悟, 小松晃之

    第62回錯体化学討論会  2012.9 

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  • ピリジル基を有するテトラフェニルポルフィリンの合成と構造体形成

    粕谷咲子, 小松晃之

    第62回錯体化学討論会  2012.9 

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  • Artificial Hemoproteins Comprising Human Serum Albumin Mutants Complexed with Iron Protoporphyrin IX（招待講演）

    T. Komatsu

    7th International Conference on Porphyrins and Phthalocyanines  2012.7 

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  • 金属ナノ粒子を階層成分として含むナノチューブの合成と特徴

    後藤峻, 小松晃之

    第6１回高分子学会年次大会  2012.5 

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  • 酸素輸送ヘム蛋白質（ヘモグロビン-アルブミン）クラスターの合成

    冨田大樹, 木村拓矢, 小松晃之

    第6１回高分子学会年次大会  2012.5 

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  • 金属貯蔵蛋白質フェリチンを用いたナノチューブの合成

    佐々木匠, 小松晃之

    第6１回高分子学会年次大会  2012.5 

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  • アビジン-ビオチン結合を利用した蛋白質ナノチューブの合成

    天野祐輔, 小松晃之

    第6１回高分子学会年次大会  2012.5 

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  • Artificial Hemoproteins Comprising Human Serum Albumin Complexed with Iron Protoporphyrin IX in a Tailor-Made Heme Pocket（招待講演）

    T. Komatsu

    12th Eurasia Conference on Chemical Sciences  2012.4 

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  • アルブミンを用いた機能分子・材料の創製-人工酸素運搬体からナノチューブまで-（招待講演）

    小松晃之

    第6回DDS熊本シンポジウム  2012.3 

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  • 人工酸素運搬体としての（ヘモグロビン-アルブミン）クラスターの合成

    保坂仁美, 冨田大樹, 小松晃之

    日本化学会第92春季年会  2012.3 

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  • （ヘモグロビン-アルブミン）クラスターの合成と酸素結合反応

    木村拓矢, 冨田大樹, 小松晃之

    日本化学会第92春季年会  2012.3 

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  • 組換えアルブミン-ヘム錯体のヘムポケット構造とペルオキシダーゼ活性の相関

    渡邉恭平, 小松晃之

    日本化学会第92春季年会  2012.3 

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  • 蛋白質ナノチューブアレイの合成とその分子捕捉能

    加藤竜之介, 小松晃之

    日本化学会第92春季年会  2012.3 

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  • Protein-Based Nanotubes for Biomolecular Traps（招待講演）

    T. Komatsu

    7th IUPAC International Conference on Novel Materials and their Synthesis &21th International Symposium on Fine Chemistry and Functional Polymers  2011.11 

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  • 組換えアルブミン-ヘム錯体のペルオキシダーゼ活性能

    渡邊恭平, 小松晃之

    第61回錯体化学討論会  2011.9 

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  • （ヘモグロビン／アルブミン）ヘテロクラスターの酸素結合反応

    冨田大樹, 小松晃之

    第61回錯体化学討論会  2011.9 

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  • 金ナノ粒子を階層成分に導入したアルブミンナノチューブの合成と構造

    後藤 峻, 小松晃之

    第60回高分子討論会  2011.9 

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  • Biomolecular Capture in Protein Nanotubes（招待講演）

    T. Komatsu

    2011 East Asian Symposium on Polymers for Advanced Technology  2011.6 

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  • コバルトフェリチンを用いた酸化コバルトナノチューブの合成と触媒活性

    加藤竜之介, 小松晃之

    第60回高分子学会年次大会  2011.5 

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  • （ヘモグロビン／アルブミン）ヘテロクラスターの合成、構造と酸素結合

    冨田大樹, 小松晃之

    第60回高分子学会年次大会  2011.5 

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  • （ヘモグロビン／アルブミン）ヘテロオリゴマーの合成と酸素結合能

    冨田大樹, 小松晃之

    第91日本化学会春季年会  2011.3 

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  • 組換えアルブミン-ヘム錯体の合成とそのペルオキシダーゼ活性

    渡邊恭平, 小松晃之

    第91日本化学会春季年会  2011.3 

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  • フェリチンを用いた金属酸化物ナノチューブの合成と触媒活性

    加藤竜之介, 小松晃之

    第91日本化学会春季年会  2011.3 

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  • 金ナノ粒子を含むアルブミンナノチューブの合成

    後藤 峻, 小松晃之

    第91日本化学会春季年会  2011.3 

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  • レクチンを再内層に有する蛋白質ナノチューブの合成と多糖捕捉能

    白石佑太, 小松晃之

    第91日本化学会春季年会  2011.3 

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  • Structural and Mutagenic Approach to Create Human Serum Albumin-Based Oxygen Carrier

    T. Komatsu

    2010 International Chemical Congress of Pacific Basin Societies (Pacifichem 2010)  2010.12 

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  • 完全合成系人工酸素運搬体の開発（招待講演）

    小松晃之

    第17回日本血液代替物学会年次大会  2010.10 

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  • 血漿蛋白質を用いた機能分子・材料の創製（招待講演）

    小松晃之

    日本学術振興会分子ナノテクノロジー第147委員会第31回研究会（東京）  2009.12 

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  • Protein Nanotubes: Synthesis, Structure and Molecular Capturing Ability

    T. Komatsu, X. Qu

    13th IUPAC International Symposium on MacroMolecular Complexes  2009.11 

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  • Protein Nanotubes for Biomolecular Separation (招待講演)

    T. Komtasu, X. Qu

    5th IUPAC International Symposium on Novel Materials and their Synthesis  2009.10 

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  • 蛋白質ナノチューブの構造制御と分子捕捉（依頼講演）

    小松晃之, 屈 雪

    第58回高分子討論会  2009.9 

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  • 蛋白質ナノチューブの構造と分子捕捉能

    屈 雪, 土田英俊, 小松晃之

    第58回高分子学会年次大会  2009.5 

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  • 蛋白質からなるナノチューブの合成と機能発現

    小松晃之, 屈 雪, 土田英俊

    第59回高分子年次大会  2009.5 

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  • 人工酸素運搬体”アルブミン-ヘム“の創製と酸素輸送（招待講演）

    小松晃之

    第36回日本集中治療医学会  2009.2 

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  • Albumin-Heme Complexes: Heme Pocket Architecture for Modulation of Oxygen-Binding Property (招待講演)

    T. Komatsu

    International Symposium on Development of Albumins with New Functions and Clinical Applications, Kumamoto  2008.11 

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  • アルブミン-フラーレン錯体の光物性と細胞毒性

    小松晃之, 屈 雪, 土田英俊, 堀之内宏久, 小林紘一

    第15回日本血液代替物学会年次大会  2008.10 

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  • O2 Binding Properties of Recombinant Albumin-Heme Complexes Having Arginine at the Entrance of the Heme Pocket

    A. Nakagawa, T. Komatsu, E. Tsuchida

    6th Current Issues on Blood Substitute Research, Tokyo  2008.10 

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  • 蛋白質ナノチューブの鋳型合成とその特徴

    屈 雪, 小松晃之, 土田英俊

    第57回高分子討論会  2008.9 

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  • 蛋白質ナノチューブの合成と構造制御（依頼講演）

    小松晃之, 屈 雪, 盧 剛, 土田英俊

    第57回高分子学会年次大会  2008.5 

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  • ヘムポケット入口にアルギニンを導入した組換えアルブミン－プロトヘム錯体の酸素結合能

    中川晶人, 小松晃之, 土田英俊

    第57高分子学会年次大会  2008.5 

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  • Characterization of Human Serum Albumin Complex with Carboxyfullerene

    X. Qu, T. Komatsu, E. Tsuchida

    11th International Symposium on Blood Substitutes  2007.10 

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  • O2 Binding Nanotubes Made of Albumin-Heme Complex

    G. Lu, T. Komatsu, E. Tsuchida

    11th International Symposium on Blood Substitutes  2007.10 

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  • Genetic Engineering of the Heme Pocket in Human Serum Albumin: Modulation of O2 Binding of Iron Protoporphyrin IX

    T. Komatsu, A. Nakagawa, E. Tsuchida

    11th International Symposium on Blood Substitutes  2007.10 

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  • O2-Binding Ability of Membrane of PEG-Modified Albumin-Hem

    A. Nakagawa, T. Komatsu, G. Lu, E. Tsuchida

    11th International Symposium on Blood Substitutes  2007.10 

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  • Polyoxyethylene-Modified Albumin-Heme Hybrid -Synthesis, Property and Oxygen-Binding Ability

    Y. Huang, T. Komatsu, E. Tsuchida

    11th International Symposium on Blood Substitutes, Beijing (China)  2007.10 

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  • Genetic Engineering of the Heme Pocket in Human Serum Albumin: Modulation of O2 Binding of Iron Protoporphyrin IX

    T. Komatsu, A. Nakagawa, E. Tsuchida

    9th International Symposium on Polymers for Advanced Technologies, Shanghai (China)  2007.10 

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  • アルブミンを用いた機能蛋白質の創製とバイオナノチューブの構築 （招待講演）

    小松晃之

    第56回高分子討論会  2007.9 

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  • PEG修飾アルブミン-ヘム薄膜の酸素結合能

    中川晶人, 小松晃之, 盧 剛, 土田英俊

    第56回高分子討論会  2007.9 

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  • Genetically Engineered Hemepocket in Human Serum Albumin: Modulation of O2 Binding to Iron Protoporphyrin IX (招待講演)

    T. Komatsu, A. Nakagawa, E. Tsuchida

    IUPAC 12th International Symposium on MacroMolecular Complexes  2007.8 

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  • Synthesis of Tetraphenylporphinatoiron(II) Derivative Bearing a Proximal Histidyl Group via Acyl Bond and Its O2-Binding Properties in Aqueous Media

    A. Nakagawa, T. Komatsu, E. Tsuchida

    IUPAC 12th International Symposium on MacroMolecular Complexes  2007.8 

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  • O2-Binding Nanotubes Made of Human Serum Albumin Incorporating Synthetic Heme

    G. Lu, T. Komatsu, E. Tsuchida

    IUPAC 12th International Symposium on MacroMolecular Complexes  2007.8 

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  • アルブミンを用いた全合成系人工酸素運搬体の創製（依頼講演）

    小松晃之, 土田英俊

    第14回日本血液代替物学会年次大会  2007.6 

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  • 組換えヒト血清アルブミン-プロトヘム錯体におけるヘムポケット構造と酸素結合能の相関

    中川晶人, 小松晃之, 土田英俊

    第14回日本血液代替物学会年次大会  2007.6 

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  • 組換えヒト血清アルブミン-プロトヘム複合体のヘムポケット構造と酸素結合能

    中川晶人, 小松晃之, 土田英俊

    第56回高分子学会年次大会（京都）  2007.5 

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  • アルブミンからなるナノチューブの合成と構造制御

    盧 剛, 小松晃之, 土田英俊

    第56回高分子学会年次大会  2007.5 

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  • ヒスチジン誘導体結合ヘムを包接したアルブミン複合体の酸素結合反応

    中川晶人, 飯塚 誠, 小松晃之, 武岡真司, 土田英俊

    第56回高分子討論会  2006.9 

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  • 機能性分子結合アルブミンからなるナノチューブの合成と特徴

    盧 剛, 小松晃之, 土田英俊

    第56回高分子討論会  2006.9 

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  • 遺伝子組換えアルブミン-プロトヘム錯体からなる新しい酸素輸送ヘム蛋白質の創製

    小松晃之, 中川晶人, 土田英俊

    日本血液代替物学会年次大会  2006.8 

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  • ポリ（エチレングリコール）修飾アルブミン-ヘムの酸素結合能と新しい特徴

    中川晶人, 黄 宇彬, 王 栄民, 小松晃之, 土田英俊

    日本血液代替物学会年次大会  2006.8 

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  • PEG Conjugated Albumin-Heme as a Blood Substitute and Its Medical Applications (招待講演)

    E. Tsuchida, T. Komatsu

    4th International Conference on Porphyrins and Phthalocyanines  2006.7 

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  • Oxygen Binding Properties of Artificial Hemoproteins Formed by Complexing Iron Protoporphyrin IX with Human Serum Albumin

    T. Komatsu, A. Nakagawa, E. Tsuchida

    4th International Conference on Porphyrins and Phthalocyanines  2006.7 

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  • Human Serum Albumin Hybrid Incorporating Tailed Porphyrinatoiron(II) in the α,α,α,β-Conformer as an O2-Binding Site

    A. Nakagawa, T. Komatsu, E. Tsuchida

    4th International Conference on Porphyrins and Phthalocyanines  2006.7 

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  • 組換えアルブミン-プロトヘムにおけるヘムポケット構造と酸素結合能の相関

    小松晃之, 中川晶人, 土田英俊

    高分子学会年次大会  2006.5 

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  • 電荷相互作用を利用したアルブミンナノチューブの鋳型合成

    盧 剛, 小松晃之, 土田英俊

    高分子学会年次大会  2006.5 

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  • アルブミン-ヘム複合体の酸素結合に及ぼすポルフィリン構造の効果

    飯塚 誠, 中川晶人, 小松晃之, 武岡真司, 土田英俊

    日本化学会春季年会  2006.3 

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  • ポリエチレングリコール鎖で表面修飾したアルブミン-ヘムの特徴と酸素結合

    黄 宇彬, 王 栄民, 小松晃之, 中川晶人, 土田英俊

    日本化学会講演予稿集,日本化学会  2006.3 

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  • 遺伝子組換えアルブミン?プロトヘム複合体の酸素結合能

    中川晶人, 小松晃之, 土田英俊

    高分子学会予稿集,高分子学会  2005.9 

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  • Dioxygenation of Human Serum Albumin Having a Prosthetic Heme Group in a Tailor-Made Heme Pocket

    T. Komatsu, E. Tsuchida

    IUPAC 11th International Symposium on Macromolecule-Metal Complexes, Pisa (Italy)  2005.9 

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  • O2 and CO Binding Ability of Human Serum Albumin Having a Prosthetic Heme Group

    T. Komatsu, E. Tsuchida

    8th International Symposium on Polymers for Advanced Technologies, Budapest (Hungary)  2005.9 

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  • 人工酸素運搬体による腫瘍酸素加と放射線治療効果増強について-実験的検討-

    堀之内宏久, 山本尚志, 小林紘一, 小松晃之, 土田英俊

    人工血液,日本血液代替物学会  2005.6 

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  • 部位特異的アミノ酸置換を利用した新しいアルブミン-ヘムの合成と酸素結合

    小松晃之, 土田英俊

    人工血液,日本血液代替物学会  2005.6 

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  • 組換えアルブミン二量体の体内動態特性について

    浦田由紀乃, 安楽 誠, 小松晃之, 土田英俊

    人工血液,日本血液代替物学会  2005.6 

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  • 新規な酸素結合サイトα3β型ヘムの合成とアルブミン-ヘムの酸素結合

    飯塚 誠, 武岡真司, 中川晶人, 小松晃之, 土田英俊

    人工血液,日本血液代替物学会  2005.6 

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  • アルブミン-ヘムの静的構造とダイナミクス

    佐藤高彰, 中川晶人, 小松晃之, 土田英俊

    人工血液,日本血液代替物学会  2005.6 

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  • ポリエチレングリコール鎖で表面修飾したアルブミン-ヘムの合成とその構造および溶液物性

    黄 宇彬, 小松晃之, 中川晶人, 王 栄民, 土田英俊

    人工血液,日本血液代替物学会  2005.6 

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  • ポリエチレングリコール鎖で表面修飾したアルブミン-ヘムの酸素結合

    中川晶人, 王 永民, 黄 宇彬, 小松晃之, 土田英俊

    人工血液,日本血液代替物学会  2005.6 

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  • Synthesis and O2-Binding Properties of Albumin-Heme Covalently Linked GluFePs as O2-Coordination Site

    王 栄民, 小松晃之, 土田英俊

    人工血液,日本血液代替物学会  2005.6 

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  • 麻酔下イヌ出血ショックモデルを用いた人工酸素輸液アルブミン-ヘムの酸素運搬能評価

    山本尚志

    人工血液,日本血液代替物学会  2005.6 

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  • Human Serum Albumin Having a Prosthetic Heme Group in a Tailor-Made Heme Pocket

    T. Komatsu, E. Tsuchida

    10th International Symposium on Blood Substitutes, Providence (USA)  2005.6 

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  • O2-Binding Properties of Albumin-Heme Hybrid Incorporating α3β-Substituted Heme Derivative

    A. Nakagawa, T. Komatsu, E. Tsuchida

    10th International Symposium on Blood Substitutes, Providence (USA)  2005.6 

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  • Polyoxyethylene-Modified Albumin-Heme Hybrid: Synthesis, Property, Oxygen-Binding Ability

    Y. Huang, T. Komatsu, R.-M. Wang, E. Tsuchida

    10th International Symposium on Blood Substitutes, Providence (USA)  2005.6 

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  • Albumin-Heme Conjugate Covalently Attached Heme Sites

    R.-M. Wang, T. Komatsu, E. Tsuchida

    10th International Symposium on Blood Substitutes, Providence (USA)  2005.6 

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  • Exchange Transfusion with Entirely Synthetic Red-Cell Substitute Albumin-Heme into Anesthetized Dogs: Physiological Responses and Oxygen Delivery

    H. Yamamoto

    10th International Symposium on Blood Substitutes, Providence (USA)  2005.6 

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  • Enhanced Radiation Response by using Artificial Oxygen Carrier: Albumin-Heme (rHSA-FecycP)

    H. Horinouchi

    10th International Symposium on Blood Substitutes, Providence (USA)  2005.6 

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  • 「組換えアルブミン-ヘム」：酸素輸送ヘム蛋白質の創製と生体利用（依頼講演）

    小松晃之

    2005-1 高分子錯体研究会,高分子学会  2005.5 

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  • α3β置換ヘム誘導体を包接したアルブミン複合体の酸素結合能

    中川晶人, 飯塚 誠, 小松晃之, 土田英俊

    高分子学会予稿集,高分子学会  2005.5 

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  • アルブミン-ヘムの表面修飾と物性・酸素結合の相関

    黄 宇彬, 中川晶人, 小松晃之, 土田英俊

    高分子学会予稿集,高分子学会  2005.5 

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  • α3β置換テトラフェニルポルフィリン鉄錯体の合成と酸素結合に及ぼす置換基構造の効果

    飯塚 誠, 中川晶人, 小松晃之, 武岡真司, 土田英俊

    日本化学会講演予稿集,日本化学会  2005.3 

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  • ポリオキシエチレン修飾アルブミン-ヘムの構造・物性と酸素結合能

    黄 宇彬, 中川晶人, 小松晃之, 土田英俊

    日本化学会講演予稿集,日本化学会  2005.3 

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  • 酸素輸送アルブミン：完全合成系人工酸素運搬体”アルブミン-ヘム”の創製と利用（招待講演）

    小松晃之

    日本集中治療医学会雑誌,日本集中治療医学会  2005.2 

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  • ヘムポケットを有する組換えアルブミンに結合させたヘム錯体の酸素結合

    大道直美, 小松晃之, 西出宏之, 土田英俊

    高分子学会予稿集,高分子学会  2004.9 

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  • 酸素結合サイトとして鉄(II)ポルフィリンを共有結合したヒト血清アルブミン

    王 栄民, 小松晃之, 土田英俊

    高分子学会予稿集,高分子学会  2004.9 

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  • α3β置換ヘム誘導体を包接したアルブミン-ヘム複合体の合成と酸素結合

    中川晶人, 小松晃之, 小黒有希子, 土田英俊

    高分子学会予稿集,高分子学会  2004.9 

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  • ヘムポケットを有する組換えアルブミンの合成とヘム錯体の酸素結合

    小松晃之, 大道直美, 土田英俊

    高分子学会予稿集,高分子学会  2004.9 

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  • アルブミン-ヘム製剤の安全性試験に関する検討

    小松晃之, 土田英俊

    人工血液,日本血液代替物学会  2004.7 

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  • α3β置換ヘム誘導体とアルブミン-ヘム複合体の酸素結合

    中川晶人, 小松晃之, 土田英俊

    人工血液,日本血液代替物学会  2004.7 

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  • アルブミン-ヘム錯体の構造と物理化学的特徴

    大道直美, 中川晶人, 小松晃之, 西出宏之, Stephen Curry, 土田英俊

    高分子学会予稿集,高分子学会  2004.5 

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  • アルブミン-プロトヘム複合体の酸素、一酸化炭素結合反応

    小黒有希子, 中川晶人, 小松晃之, 武岡真司, 土田英俊

    高分子学会予稿集,高分子学会  2004.5 

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  • 酸素輸送合成ヘム蛋白質“アルブミン-ヘム”の創製と酸素輸液の展開（教育講演）

    小松晃之, 土田英俊

    第19回体液・代謝管理研究会予稿集,体液代謝管理研究会  2004.1 

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  • アルブミン二量体の特徴とヘム複合体の酸素結合反応

    小黒由希子, 小松晃之, 武岡真司, 土田英俊

    人工臓器,日本人工臓器学会  2003.10 

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  • ジアセチルデューテロヘム誘導体を活性中心とするアルブミン-ヘム複合体の酸素結合反応

    中川晶人, 小松晃之, 大道直美, 土田英俊

    人工臓器,日本人工臓器学会  2003.10 

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  • ラット脱血ショックモデルを用いたアルブミン-ヘムの酸素運搬能評価

    黄 宇彬

    人工臓器,日本人工臓器学会  2003.10 

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  • 人工酸素運搬体“アルブミン-ヘム”の特徴と酸素輸送能 （招待講演）

    小松晃之, 土田英俊

    第18回日本薬物動態学会年会予稿集,日本薬物動態学会  2003.10 

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  • 酸素輸送合成ヘム蛋白質“アルブミン-ヘム”の構築と生体への応用（依頼講演）

    小松晃之, 土田英俊

    高分子学会予稿集,高分子学会  2003.9 

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  • テトラシクロヘキサノイル置換ポルフィリン鉄を包接したアルブミン複合体の酸素結合反応

    石原星児, 小松晃之, 西出宏之, 土田英俊

    高分子学会予稿集,高分子学会  2003.9 

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  • Energy and Electron Transfer Assemblies Made of Self-organized Lipid-porphyrins in Water

    T. Komatsu, E. Tsuchida

    7th International Symposium on Polymers for Advanced Technologies, Fort Landerdale (USA)  2003.9 

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  • ポルフィリン二分子膜小胞体における光誘起エネルギー移動

    小松晃之, 森武美保, 土田英俊

    高分子学会予稿集,高分子学会  2003.5 

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  • 近位塩基を有するプロトヘム誘導体の合成とそのアルブミン包接体の酸素結合反応

    中川晶人, 小松晃之, 土田英俊

    高分子学会予稿集,高分子学会  2003.5 

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  • Molecular Energy and Electron Transfer Assemblies Made of Self-organized Lipid-porphyrins

    T. Komatsu, E. Tsuchida

    IUPAC 10th International Symposium on Macromolecule-Metal Complexes, Moscow (Russia)  2003.5 

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  • Physiological Response and Oxygen Derivery of Albumin-Heme in Exchange Transfusion into Rats

    Y. Huang, T. Komatsu, E. Tsuchida

    IUPAC 10th International Symposium on Macromolecule-Metal Complexes, Moscow (Russia)  2003.5 

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  • Human Serum Albumin Hybrids Including Iron Complex of Protoporphyrin IX Derivative with a Proximal Base and Their Dioxygenation

    A. Nakagawa, T. Komatsu, E. Tsuchida

    IUPAC 10th International Symposium on Macromolecule-Metal Complexes, Moscow (Russia)  2003.5 

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  • ビスマレイミドヘキサン架橋ヒト血清アルブミンの特徴

    小黒有希子, 小松晃之, 寺村裕治, 武岡真司, 土田英俊

    日本化学会講演予稿集,日本化学会  2003.3 

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  • 耐熱蛋白質-鉄ポルフィリン複合体の酸素結合反応

    石原星児, 小松晃之, 土田英俊, 西出宏之, 諸熊千尋, 中村 聡

    日本化学会講演予稿集,日本化学会  2003.3 

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  • Serum Albumin Including Synthetic Hemes as an Oxygen-Carrying Hemoprotein (招待講演)

    T. Komatsu, E. Tsuchida

    9th International Symposium on Blood Substitutes, Tokyo  2003.3 

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  • Human Serum Albumin Hybrids Including Iron Complex of Protoporphyrin IX with a Proximal Base and Their Dioxygenation

    A. Nakagawa, T. Komatsu, E. Tsuchida

    9th International Symposium on Blood Substitutes, Tokyo  2003.3 

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  • Compatibility of Albumin-heme with Blood Cell Components

    Y. Huang, T. Komatsu, E. Tsuchida

    9th International Symposium on Blood Substitutes, Tokyo  2003.3 

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  • Exchange Transfusion of Albumin-Heme as an Artificial Oxygen Carrier into Anesthetized Rats: Phyiological Responses and Oxygen Delivery

    H. Yamamoto

    9th International Symposium on Blood Substitutes, Tokyo  2003.3 

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  • 近位塩基を有する鉄プロトポルフィリンの合成とアルブミン包接体の酸素結合反応

    大道直美, 中川晶人, 小松晃之, 西出宏之, 土田英俊

    日本化学会講演予稿集,日本化学会  2003.3 

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  • リピドポルフィリン二分子膜小胞体の微細構造と光誘起エネルギー移動

    森武美保, 小松晃之, 西出宏之, 土田英俊

    高分子学会予稿集,高分子学会  2002.10 

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  • アルブミン-プロトヘム複合体の合成と酸素配位

    中川晶人, 小松晃之, 土田英俊

    人工臓器,日本人工臓器学会  2002.10 

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  • 酸素輸送合成ヘム蛋白質（アルブミン-ヘム）の機能制御

    小松晃之, 土田英俊

    人工臓器,日本人工臓器学会  2002.10 

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  • 人工赤血球：研究開発の現状と臨床応用

    堀之内宏久

    人工臓器,日本人工臓器学会  2002.10 

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  • アルブミン-ヘムのO2、CO配位構造と再結合過程のピコ秒時間分解解析

    小松晃之, 中川晶人, 土田英俊

    人工血液,日本血液代替物学会  2002.9 

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  • アルブミン-ヘムの血液適合性：in vitro における評価

    黄 宇彬, 小松晃之, 中川晶人, 土田英俊

    人工血液,日本血液代替物学会  2002.9 

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  • アルブミン-プロトヘム複合体の合成とその酸素配位

    中川晶人, 小松晃之, 土田英俊

    人工血液,日本血液代替物学会  2002.9 

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  • O2-Carrying Albumin: Oxygen-Binding Property and Efficacy as Red Blood Cell Substitute

    T. Komatsu, E. Tsuchida

    30th Annual Meeting of the International Society on Oxygen Transport to Tissues, Manchester (UK)  2002.8 

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  • Serum Albumin Included Iron-porphyrins as a Novel Synthetic O2-Carrying Hemoprotein (Invited lecture)

    T. Komatsu, E. Tsuchida

    2nd International Conference on Porphyrins and Phthalocyanines, Kyoto  2002.7 

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  • Coordination Structure and Geminate Recombination of Albuin-heme with O2 and CO

    A. Nakagawa, T. Komatsu, E. Tsuchida

    2nd International Conference on Porphyrins and Phthalocyanines, Kyoto  2002.7 

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  • Biocompatibility of Albumin Included Hemes as a Synthetic O2-Carrier

    Y. Huang, T. Komatsu, E. Tsuchida

    2nd International Conference on Porphyrins and Phthalocyanines, Kyoto  2002.7 

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  • Self-Organized Lipid-Porphyrin Bilayer Membranes in Vesicular Form: Nano-Structure and O2-Coordination

    M. Moritake, T. Komatsu, H. Nishide, E. Tsuchida

    2nd International Conference on Porphyrins and Phthalocyanines, Kyoto  2002.7 

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  • Serum Albumin Included Hemes as a Novel Synthetic O2-Carrying Hemoprotein

    E. Tsuchida, T. Komatsu, A. Nakagawa

    6th International Porphyrin-Heme Symposium, Tokyo  2002.7 

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  • Self-Organized Lipid-Porphyrin Bilayer Membranes in Vesicular Form: Nano-Structure, Photophysical Property and O2-Coordination

    T. Komatsu, M. Moritake, H. Nishide, E. Tsuchida

    6th International Porphyrin-Heme Symposium, Tokyo  2002.7 

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  • Serum Albumin Included Iron-Porphyrins as a Synthetic O2-Carrying Hemoprotein

    T. Komatsu, A. Nakagawa, E. Tsuchida

    4th Current Issues in Blood Substitute Research, Stockholm (Sweden)  2002.6 

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  • O2-Coordination and Biocompatibility of Albumin-Heme as a Synthetic O2-Carrier

    A. Nakagawa, T. Komatsu, E. Tsuchida

    4th Current Issues in Blood Substitute Research, Stockholm (Sweden)  2002.6 

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  • 両親媒性テトラフェニルポルフィリン-プロトポルフィリンからなる二分子膜小胞体の光電子移動反応

    小松晃之, 森武美保, 西出宏之, 土田英俊

    高分子学会予稿集,高分子学会  2002.5 

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  • アルブミンに包接させたヘムの配位構造とO2,、CO結合過程

    中川晶人, 小松晃之, 土田英俊

    高分子学会予稿集,高分子学会  2002.5 

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  • アルブミン-ヘム複合体の酸素結合過程と配位構造

    中川晶人, 小松晃之, 土田英俊

    日本化学会講演予稿集,日本化学会  2002.3 

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  • リピドポルフィリンが自己組織化して形成する小胞体の微細構造と酸素配位

    森武美保, 小松晃之, 西出宏之, 土田英俊

    日本化学会講演予稿集,日本化学会  2002.3 

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  • ２種のリピドポルフィリンが共組織化して形成する二分子膜小胞体の光電子移動反応

    小松晃之, 森武美保, 西出宏之, 土田英俊

    日本化学会講演予稿集,日本化学会  2002.3 

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  • イミダゾリル基を有するリン脂質の合成とプロトポルフィリン共組織体の特徴

    石原星児, 小松晃之, 西出宏之, 土田英俊

    日本化学会講演予稿集,日本化学会  2002.3 

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  • 酸素輸液を目指したポルフィリン組織体の構築と機能（依頼講演）

    小松晃之

    2001-2高分子錯体研究会予稿集,高分子学会  2002.1 

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  • 全合成系酸素輸液：アルブミン-ヘム複合体 -ヘム構造が酸素配位能に与える効果-（依頼講演）

    小松晃之, 土田英俊

    人工血液,日本血液代替物学会  2001.9 

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  • 全合成系酸素輸液としてのリピドヘム小胞体の構造と酸素輸送能

    中川晶人, 森武美保, 小松晃之, 小林 修, 土田英俊

    人工血液,日本血液代替物学会  2001.9 

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  • リピドポルフィリンが自己組織化して形成する二分子膜小胞体の特徴と酸素配位

    小松晃之, 森武美保, 土田英俊

    高分子学会予稿集,高分子学会  2001.9 

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  • リピドポルフィリンとイミダゾール誘導体が自己組織化して形成する組織体の特徴と酸素配位

    中川晶人, 森武美保, 小松晃之, 小林 修, 土田英俊

    高分子学会予稿集,高分子学会  2001.9 

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  • ポルフィリンが自己組織化して構成する二分子膜小胞体の特徴と酸素配位能

    小松晃之, 森武美保, 土田英俊

    錯体化学討論会講演要旨集,錯体化学研究会  2001.9 

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  • Human Serum Albumin Incorporating Lipidhemes as an Oxygen-Infusion (Key Note Lecture)

    T. Komatsu, E. Tsuchida

    6th International Symposium on Polymers for Advanced Technologies, Eilat (Israel)  2001.9 

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  • Self-assembled Bilayer Vesicle Made of Amphiphilic Porphyrin: Nano-structure and O2-Coordination

    T. Komatsu, M. Moritake, E. Tsuchida

    6th International Symposium on Polymers for Advanced Technologies, Eilat (Israel)  2001.9 

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  • Self-Assembled Bilayer Vesicle Made of Tetraphenylporphyrin with Dialkylphosphocholine Groups: Nano-Structure and O2-Coordination

    T. Komatsu, M Moritake, E. Tsuchida

    IUPAC 9th International Symposium on Macromolecule-Metal Complexes, New York (USA)  2001.8 

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  • Photoreduction of Self-Assembled Lipidporphyrinato-Iron(III) Complex in Saline by LMCT Excitation

    A. Nakagawa, T. Komatsu, E. Tsuchida

    IUPAC 9th International Symposium on Macromolecule-Metal Complexes, New York (USA)  2001.8 

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  • 近位塩基を有する新規ヘムの合成とアルブミン複合体の酸素配位能

    小松晃之, 松川泰子, 岡田智行, 土田英俊

    高分子学会予稿集,高分子学会  2001.5 

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  • アルブミン-ヘム複合体の酸素錯体安定度に及ぼすヘム構造の効果

    小松晃之, 松川泰子, 土田英俊

    日本化学会講演予稿集,日本化学会  2001.3 

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  • ４つのジアルキルホスホコリン基を有するテトラフェニルポルフィリンの合成とその自己組織体の特徴

    森武美保, 中川晶人, 小松晃之, 土田英俊

    日本化学会講演予稿集,日本化学会  2001.3 

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  • プロトヘム誘導体を包接したアルブミン複合体の特徴と酸素配位

    宮武 薫, 小松晃之, 土田英俊

    日本化学会講演予稿集,日本化学会  2001.3 

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  • Nano-structure and Dioxygenation of Self-assembled Lipidporphyrins in Aqueous Media

    T. Komatsu, T. Yanagimoto, S. Hayakawa, E. Tsuchida

    The 2000 International Chemical Congress of Pacific Basin Societies, Honolulu (USA)  2000.12 

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  • Reaction of Nitric Oxide with Recombinant Human Serum Albumin Incorporating Synthetic Hemes

    Y. Mastukawa, T. Komatsu, E. Tsuchida

    The 2000 International Chemical Congress of Pacific Basin Societies, Honolulu (USA)  2000.12 

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  • Photoreduction of Tetraphenylporphinato-Iron(III) Derivative Incorporated into Recombinant Human Serum Albumin by LMCT Irradiation

    A. Nakagawa, T. Komatsu, E. Tsuchida

    The 2000 International Chemical Congress of Pacific Basin Societies, Honolulu (USA)  2000.12 

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  • Human Serum Albumin-Heme Hybrid as Dioxygen Infusion

    E. Tsuchida, T. Komatsu

    The 2000 International Chemical Congress of Pacific Basin Societies, Honolulu (USA)  2000.12 

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  • NO-Binding Properties of Recombinant Human Serum Albumin Incorporating Synthetic Heme (Albumin-Heme)

    T. Komatsu, Y. Mastukawa, E. Tsuchida

    8th International Symposium on Blood Substitute, San Diego (USA)  2000.11 

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  • 全合成系酸素運搬体（アルブミン-ヘム）のNO配位能

    小松晃之, 松川泰子, 土田英俊

    人工血液,日本血液代替物学会  2000.9 

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  • ヒスチジンを軸塩基とするテトラフェニルポルフィリン鉄(II)誘導体の合成とアルブミン複合体の酸素配位

    松川泰子, 小松晃之, 土田英俊

    錯体化学討論会講演要旨集,錯体化学研究会  2000.9 

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  • 両面修飾テトラフェニルポルフィリン鉄(II)誘導体の合成と酸素配位に及ぼす置換基効果

    岡田智行, 小松晃之, 土田英俊

    錯体化学討論会講演要旨集,錯体化学研究会  2000.9 

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  • アルブミン-ヘム複合体（全合成系酸素輸液）の特徴と酸素輸送

    小松晃之, 土田英俊

    第5回酸素ダイナミクス研究会要旨集,酸素ダイナミクス研究会  2000.9 

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  • 光照射によるアルブミン-ヘムの還元反応

    中川晶人, 小松晃之, 土田英俊

    高分子学会予稿集,高分子学会  2000.9 

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  • オクトパスポルフィリン組織体の構造と酸素配位

    柳本徹也, 早川祥一, 小松晃之, 土田英俊

    高分子学会予稿集,高分子学会  2000.9 

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  • Inclusion Complexes of Albumin-Lipidheme Playing a Role of Oxygen Infusions

    E. Tuschida, T. Komatsu

    38th Macromolecular IUPAC Symposium, Warsaw (Poland)  2000.7 

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  • Reaction of Nitric Oxide with Human Serum Albumin Incorporating Tetraphenylporphinatoiron(II) Derivatives

    T. Komatsu, Y. Matsukawa, E. Tsuchida

    1st International Conference on Porphyrins and Phthalocyanines, Dijion (France)  2000.6 

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  • Self-Assembled Fibers Made of Lipidporphyrinato-Zinc(II) and -Iron(II) Complexes with an Intramolecular Coordinated Axial Imidazole

    T. Komatsu, T. Yanagimoto, E. Tsuchida

    1st International Conference on Porphyrins and Phthalocyanines, Dijion (France)  2000.6 

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  • ポルフィリン組織体の構築とその酸素輸液への応用（若手招待講演）

    小松晃之

    高分子学会予稿集,高分子学会  2000.5 

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  • アルブミン-ヘム複合体のNO結合反応

    松川泰子, 小松晃之, 土田英俊

    高分子学会予稿集,高分子学会  2000.5 

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  • Electrochemistry of Human Serum Albumin-Heme Hybrid

    呉 宇平, 小松晃之, 土田英俊

    高分子学会予稿集,高分子学会  2000.5 

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  • アルブミン-ヘムのNO配位とその結合パラメータ

    松川泰子, 小松晃之, 土田英俊

    日本化学会講演予稿集,日本化学会  2000.3 

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  • 両面修飾テトラフェニルポルフィリンの合成と血清アルブミンへの包接

    岡田智之, 小松晃之, 土田英俊

    日本化学会講演予稿集,日本化学会  2000.3 

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  • ヒスチジンを軸塩基として導入したテトラフェニルポルフィリン鉄誘導体の合成と酸素配位

    宮武 薫, 小松晃之, 土田英俊

    日本化学会講演予稿集,日本化学会  2000.3 

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  • 光照射を利用したアルブミン-ヘムの還元反応

    中川晶人, 小松晃之, 土田英俊

    日本化学会講演予稿集,日本化学会  2000.3 

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  • イミダゾリル基を共有結合したオクトパスポルフィリン鉄の合成

    早川祥一, 小早川牧子, 柳本徹也, 小松晃之, 土田英俊

    日本化学会講演予稿集,日本化学会  2000.3 

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  • 自己組織化したリピドポルフィリン集合体の構造と酸素配位

    柳本徹也, 小松晃之, 土田英俊

    日本化学会講演予稿集,日本化学会  2000.3 

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  • アルブミン-ヘムに見られる特異なO2、CO結合反応

    小松晃之, 松川泰子, 土田英俊

    高分子学会予稿集,高分子学会  1999.11 

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  • アミノ酸結合テトラフェニルポルフィリン鉄錯体の合成と酸素配位

    岡田智行, 小松晃之, 土田英俊

    錯体化学討論会講演要旨集,錯体化学研究会  1999.10 

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  • アルブミン-ヘムの構造とO2、CO結合反応の動力学的解析

    松川泰子, 小松晃之, 土田英俊

    錯体化学討論会講演要旨集,錯体化学研究会  1999.10 

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  • Self-Assembled Fibers Made of Lipidporphyrinato-Zinc(II) and -Iron(III) Complexes with an Intramolecular Coordinated Axial Imidazole

    T. Yanagimoto, T. Komatsu, E. Tsuchida

    IUPAC 8th International Symposium on Macromolecule-Metal Complexes, Tokyo  1999.9 

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  • Human Serum Albumin Incorporating Tetraphenyl- porphinatoiron(II) Derivative as a Synthetic O2-Carrying Molecule

    J. Wu, T. Komatsu, E. Tsuchida

    IUPAC 8th International Symposium on Macromolecule-Metal Complexes, Tokyo  1999.9 

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  • Kinetics of O2- and CO-Binding to Human Serum Albumin-Heme Hybrid

    Y. Matsukawa, T. Komatsu, E. Tsuchida

    IUPAC 8th International Symposium on Macromolecule-Metal Complexes, Tokyo  1999.9 

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  • Crosslinked Human Serum Albumin Dimer Incorporating Sixteen Tetraphenylporphinatoiron(II) Derivatives: Synthesis, Characterization, and O2-Binding Property

    T. Komatsu, K. Hamamatsu, E. Tsuchida

    IUPAC 8th International Symposium on Macromolecule-Metal Complexes, Tokyo  1999.9 

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  • Preparation of Anode Materials for Lithium Ion Batteries under Mild Conditions

    Y. Wu, T. Komatsu, E. Tsuchida

    IUPAC 8th International Symposium on Macromolecule-Metal Complexes, Tokyo  1999.9 

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  • 二量化アルブミン-ヘムの特徴と酸素結合能

    小松晃之, 土田英俊

    人工血液,日本血液代替物学会  1999.9 

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  • Exchange Transfusion with Albumin-Heme as an Artificial O2-Infusion into Hemorrhagic Shock Rats: Physiological Responses, O2-Delivery and Reduction of the Oxidized Hemin Sites by Red Blood Cells

    T. Komatsu, E. Tsuchida, K. Kobayashi

    5th International Symposium on Polymers for Advanced Technologies, Tokyo  1999.8 

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  • ポルフィリン組織体とその酸素輸液への応用（招待講演）

    小松晃之

    第23回高分子錯体若手懇談会予稿集,高分子学会  1999.7 

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  • LMCT遷移の光励起を利用したリピドポルフィリン鉄(III)集合体の還元反応

    柳本徹也, 中川晶人, 小松晃之, 土田英俊

    高分子学会予稿集,高分子学会  1999.5 

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  • 二量化アルブミン-ヘムの構造と酸素配位

    小松晃之, 浜松和芳, 土田英俊

    高分子学会予稿集,高分子学会  1999.5 

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  • Dioxygen Coordination of Self-Assembled Bimolecular Fibers Made of Lipidporphyrinatoiron(II) Complexes with a Covalently Linked Axial Imidazole

    T. Komatsu, T. Yanagimoto, E. Tsuchida

    217th ASC National Meeting, Anaheim (USA)  1999.3 

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  • Photoreduction of Lipidporphyrinato-iron(III) Co-assembly with Hyaluronic Acid by Irradiation of Ligand-Metal Charge Transfer Band

    T. Komatsu, T. Yanagimoto, E. Tsuchida

    217th ASC National Meeting, Anaheim (USA)  1999.3 

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  • Dioxygen Carrying Property of Serum Albumin Incorporating Tetraphenylporphyrinatoiron(II) Derivative

    J. Wu, T. Komatsu, E. Tsuchida

    217th ASC National Meeting, Anaheim (USA)  1999.3 

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  • Human Serum Albumin-Heme Hybrid as Dioxygen Infusion

    T. Komatsu, E. Tsuchida

    217th ASC National Meeting, Anaheim (USA)  1999.3 

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  • Lipidheme Vesicles and Hemoglobin Vesicles as Dioxygen Infusion

    T. Komatsu, S. Takeoka, H. Sakai, E. Tsuchida

    217th ASC National Meeting, Anaheim (USA)  1999.3 

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  • リピドポルフィリン鉄(III)集合体の光還元反応

    中川晶人, 柳本徹也, 小松晃之, 土田英俊

    日本化学会講演予稿集,日本化学会  1999.3 

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  • リピドポルフィリン鉄(III)/亜鉛(II)共集合体の特徴と電子過程

    柳本徹也, 小松晃之, 土田英俊

    日本化学会講演予稿集,日本化学会  1999.3 

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  • リコンビナントアルブミン-ヘム複合体の酸素配位反応

    松川泰子, 小松晃之, 土田英俊

    日本化学会講演予稿集,日本化学会  1999.3 

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  • 二量化アルブミン-ヘム複合体の構造と酸素配位

    小松晃之, 浜松和芳, 岡田智行, 土田英俊

    日本化学会講演予稿集,日本化学会  1999.3 

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  • 近位塩基を有するテトラフェニルポルフィリン鉄の酸素配位

    古林祐佳, 小松晃之, 土田英俊

    日本化学会講演予稿集,日本化学会  1999.3 

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  • Porphyrin Fibers (Invited Lecture)

    T. Komatsu, E. Tsuchida

    4th International Porphyrin Heme Symposium, Yonago  1998.10 

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  • Human Serum Albumin Incorporating Synthetic Hemes: Structure, Solution Properties and O2-Binding Kinetics

    J. Wu, T. Komatsu, E. Tsuchida

    4th International Porphyrin Heme Symposium, Yonago  1998.10 

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  • アルブミン-ヘム複合体の酸素結合能

    小松晃之, 浜松和芳, 土田英俊

    人工血液,日本血液代替物学会  1998.9 

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  • 自己組織化したリピドポルフィリンファイバーの構造と酸素配位特性

    小松晃之, 土田英俊

    日本化学会講演予稿集,日本化学会  1998.9 

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  • リピドポルフィリン繊維の構造と光還元反応

    柳本徹也, 小松晃之, 土田英俊

    高分子学会予稿集,高分子学会  1998.9 

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  • 遺伝子組換えアルブミン-ヘム複合体の構造と酸素結合反応

    浜松和芳, 小松晃之, 土田英俊

    高分子学会予稿集,高分子学会  1998.9 

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  • Resonance Raman Studies of Dioxygen Binding to Porphyrinato- iron(II) Derivatives with Covalently Linked Axial Imdazole

    Jian Wu, 小松晃之, 土田英俊

    錯体化学討論会講演要旨集,錯体化学研究会  1998.9 

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  • リピドヘム集合体の光還元と酸素配位構造

    小松晃之, 柳本徹也, Jian Wu, 土田英俊

    錯体化学討論会講演要旨集,錯体化学研究会  1998.9 

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  • 軸塩基を共有結合したリピドポルフィリン集合体の構造と酸素配位

    柳本徹也, 古林祐佳, 小松晃之, 土田英俊

    高分子学会予稿集,高分子学会  1998.5 

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  • アルブミン-ヘムの構造と酸素配位反応

    小松晃之, 浜松和芳, 土田英俊

    高分子学会予稿集,高分子学会  1998.5 

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  • 分子内に軸塩基を有するリピドポルフィリンの合成

    古林祐佳, 柳本徹也, 小松晃之, 土田英俊

    日本化学会講演予稿集,日本化学会  1998.3 

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  • リピドポルフィリンの分子集合構造と電子状態

    柳本徹也, 古林祐佳, 小松晃之, 土田英俊

    日本化学会講演予稿集,日本化学会  1998.3 

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  • リピドポルフィリン集合体の酸素結合反応

    小松晃之, 柳本徹也, 古林祐佳, 土田英俊

    日本化学会講演予稿集,日本化学会  1998.3 

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  • テトラナフチルヘムの合成と酸素配位

    小松晃之, 佐野 薫, 土田英俊

    日本化学会講演予稿集,日本化学会  1998.3 

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  • アルブミン-ヘム複合体の構造

    浜松和芳, 小松晃之, 土田英俊

    日本化学会講演予稿集,日本化学会  1998.3 

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  • Non-Covalent and Covalent Tetra-anilinobixinamide-porphyrin Assemblies in Aqueous Media

    T. Komatsu, E. Tsuchida, J.-H. Fuhrhop

    IUPAC 7th International Symposium on Macromolecule-Metal Complexes, Leiden (Netherlands)  1997.10 

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  • Photophysikalische und Photochemische Eigenschafen von Porphyrinaggregaten

    U. Siggel

    Deutschen Bunsen-Gesellschaft f?r Physikalsche Chemie, Yena (Germany)  1996.5 

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  • Metalloporphyrin Heterodimers, Molecular Bilayer Fibers and Monolayer Leaflets

    J.-H. Fuhrhop

    IUPAC 6th International Symposium on Macromolecule-Metal Complexes, Kaunzhou (China)  1995.11 

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  • オクトパスポルフィリン集合体の構造と酸素配位

    山田和弘, 川合宣行, 小松晃之, 西出宏之, 土田英俊

    高分子学会予稿集,高分子学会  1995.11 

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  • 人工酸素運搬体（アルブミン-ヘム）の調製と特徴

    川合宣行, 安藤克利, 小松晃之, 西出宏之, 土田英俊

    人工血液,日本血液代替物学会  1995.6 

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  • アルブミン-ヘム錯体のO2結合反応

    安藤克利, 小松晃之, 川合宣行, 西出宏之, 土田英俊

    高分子学会予稿集,高分子学会  1995.5 

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  • リピドプロトヘムの酸素結合反応

    川合宣行, 柳本徹也, 小松晃之, 西出宏之

    日本化学会講演予稿集,日本化学会  1995.3 

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  • 分子集合体に包埋したリピドポルフィリンの特徴と酸素結合

    川合宣行, 小松晃之, 西出宏之, 土田英俊

    錯体化学討論会講演要旨集,錯体化学研究会  1994.11 

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  • オクトパスポルフィリン集合組織の構造と特徴

    山田和弘, 小松晃之, 西出宏之, 土田英俊

    錯体化学討論会講演要旨集,錯体化学研究会  1994.11 

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  • リピドポルフィリンの集合組織と機能

    小松晃之, 山田和弘, 西出宏之, 土田英俊

    高分子学会予稿集,高分子学会  1994.10 

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  • 全合成系人工赤血球（lipidheme-microsphere）の設計と機能

    小松晃之, 西出宏之, 土田英俊

    人工血液,日本血液代替物学会  1994.6 

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  • 全合成系人工赤血球（lipidheme-microsphere）の脱血犬における実験的検討

    柿崎 徹, 泉陽太郎, 小林紘一, 小松晃之, 西出宏之, 土田英俊

    人工血液,日本血液代替物学会  1994.6 

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  • 親疎水性アルキル基を有するリピドポルフィリンの特徴と酸素結合

    小松晃之, 山田和弘, 西出宏之, 土田英俊

    高分子学会予稿集,高分子学会  1994.5 

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  • リン脂質小胞体包埋リピドポルフィリンの酸素結合

    山田和弘, 小松晃之, 西出宏之, 土田英俊

    日本化学会講演予稿集,日本化学会  1994.4 

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  • ４置換リピドポルフィリンの合成と特徴

    柳沢 諭, 小松晃之, 西出宏之, 土田英俊

    日本化学会講演予稿集,日本化学会  1994.4 

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  • リピドポルフィリン小胞体の特徴

    川合 宣行, 小松晃之, 西出宏之, 土田英俊

    日本化学会講演予稿集,日本化学会  1994.4 

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  • 脂質イミダゾールを軸配位子とするリピドヘム輸滴小球の特徴と酸素配位

    小松晃之, 村松靖子, 西出宏之, 土田英俊

    日本化学会講演予稿集,日本化学会  1994.4 

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  • Lipidporphyrin Assembly as Totally Synthetic O2-Carrier

    T. Komastu, H. Nishide, E. Tsuchida

    2nd International Symposium on Polymers for Advanced Technologies, Oxford (UK)  1993.9 

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  • リピドポルフィリン被覆油滴小球の構造と特徴

    小松晃之, 川合宣行, 西出宏之, 土田英俊

    錯体化学討論会講演要旨集,錯体化学研究会  1993.9 

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  • リピドポルフィリンの合成とその集合組織

    小松晃之, 荒井健次, 西出宏之, 土田英俊

    高分子学会予稿集,高分子学会  1993.9 

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  • Molecular Assembly of 2- or 4-Substituted Amphiphilic Protoporphyrin

    T. Komatsu, K. Arai, H. Nishide, E. Tsuchida

    IUPAC 5th International Symposium on Macromolecule-Metal Complexes, Bremen (Germany)  1993.8 

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  • Morphology and O2-Binding of Lipidporphyrin Vesicle

    K. Arai, T. Komatsu, H. Nishide, E. Tsuchida

    IUPAC 5th International Symposium on Macromolecule-Metal Complexes, Bremen (Germany)  1993.8 

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  • Totally Synthetic Artificial Red Blood Cell Substitute -Lipidheme-microsphere (LH-M)-

    K. Kobayashi, T. Kakizaki, T. Komatsu, H. Nishide, E. Tsuchida

    39th Annual ASAIO Meeting, New Orins (USA)  1993.5 

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  • プロトポルフィリン誘導体の集合組織と小胞体包埋

    小松晃之, 鳥屋野敦之, 熊本伸一, 西出宏之, 土田英俊

    高分子学会予稿集,高分子学会  1993.5 

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  • リピドポルフィリン集合組織の形態と特徴

    荒井健次, 小松晃之, 熊本伸一, 西出宏之, 土田英俊

    高分子学会予稿集,高分子学会  1993.5 

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  • Structure and Solution Properties of Lipidheme-Microsphere

    T. Komatsu, H. Nishide, E. Tsuchida

    5th International Symposium on Blood Substitutes, San Diego (USA)  1993.3 

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  • Lipidheme-Microsphere (LH-M) -A New Type of Totally Synthetic Oxygen Carrier and Its Oxygen Carrying Ability

    T. Kakizaki, K. Kobayashi, T. Komatsu, H. Nishide, E. Tsuchida

    5th International Symposium on Blood Substitutes, San Diego (USA)  1993.3 

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  • Two Types of Totally Artificial Red Blood Substitutes

    K. Kobayashi, T. Kakizaki, T. Komatsu, H. Nishide, E. Tsuchida

    5th International Symposium on Blood Substitutes, San Diego (USA)  1993.3 

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  • リピドヘム小球の特徴と酸素配位

    川合宣行, 小松晃之, 西出宏之, 土田英俊

    日本化学会講演予稿集,日本化学会  1993.3 

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  • リピドポルフィリン小胞体の構造と酸素配位

    荒井健次, 小松晃之, 西出宏之, 土田英俊

    日本化学会講演予稿集,日本化学会  1993.3 

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  • Molecular Assembly of Tetraphenylporphinatoiron

    T. Komatsu, E. Tsuchida, H. Nishide

    4th SPSJ International Polymer Conference, Yokohama  1992.12 

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  • リピドヘム被覆油滴小球による酸素運搬

    小松晃之, 西出宏之, 土田英俊

    高分子学会予稿集,高分子学会  1992.11 

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  • ポルフィリン集合組織の合成と特徴

    小松晃之, 荒井健次, 西出宏之, 土田英俊

    錯体化学討論会講演要旨集,錯体化学研究会  1992.10 

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  • 2-位置置換ヘムの合成と酸素配位の動力学

    熊本伸一, 小松晃之, 西出宏之, 土田英俊

    錯体化学討論会講演要旨集,錯体化学研究会  1992.10 

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  • Liposome-embedded-heme (L/H) as a Totally Synthetic Red Blood Cell Substitute

    K. Kobayashi

    38th Annual ASAIO Meeting, Nashville (USA)  1992.5 

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  • リピドヘム-マイクロスフェアの酸素配位反応

    小松晃之, 松渕永里子, 西出宏之, 土田英俊

    高分子学会予稿集,高分子学会  1992.5 

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  • リピドヘム-マイクロスフェア（LH-M）の形態と物理化学的特徴

    小松晃之, 松渕永里子, 西出宏之, 土田英俊

    日本化学会講演予稿集,日本化学会  1992.4 

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  • 近位塩基を有する両面修飾ヘムの酸素配位

    荒井健次, 小松晃之, 西出宏之, 土田英俊

    日本化学会講演予稿集,日本化学会  1992.4 

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  • 2-位置側鎖を有するポルフィナト鉄（FeT(piv)4PP）の合成と酸素配位の特徴

    熊本伸一, 小松晃之, 西出宏之, 土田英俊

    日本化学会講演予稿集,日本化学会  1992.4 

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  • 両親媒性ヘム集合体の特徴とその酸素配位反応

    中尾啓輔, 小松晃之, 西出宏之, 土田英俊

    高分子学会予稿集,高分子学会  1991.11 

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  • 近位塩基を有する両面修飾ヘムの合成と酸素配位

    小松晃之, 西出宏之, 土田英俊

    錯体化学討論会講演要旨集,錯体化学研究会  1991.10 

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  • アミド基を導入した両面修飾ヘムの合成と酸素配位平衡

    熊本伸一, 小松晃之, 西出宏之, 土田英俊

    錯体化学討論会講演要旨集,錯体化学研究会  1991.10 

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  • α4β4-８置換ヘムの合成と酸素配位反応

    小松晃之, 中尾啓輔, 西出宏之, 土田英俊

    日本化学会講演予稿集,日本化学会  1991.9 

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  • 両親媒性ポルフィリン分子集合体

    中尾啓輔, 小松晃之, 長谷川悦雄, 西出宏之, 土田英俊

    高分子学会予稿集,高分子学会  1991.6 

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  • 両面修飾 Double-Sided ポルフィリンの合成と性質

    中尾啓輔, 小松晃之, 長谷川悦雄, 西出宏之, 土田英俊

    日本化学会講演予稿集,日本化学会  1991.3 

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  • Double-Sided コバルトポルフィリンの軸配位反応

    熊本伸一, 小松晃之, 長谷川悦雄, 西出宏之, 土田英俊

    日本化学会講演予稿集,日本化学会  1991.3 

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  • Double-Sided ポルフィリン鉄－CO 錯体の光解離率

    小松晃之, 中田大作, 長谷川悦雄, 西出宏之, 土田英俊

    日本化学会講演予稿集,日本化学会  1991.3 

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  • 両面修飾ヘム配位反応に及ぼすポケットサイズの影響

    長谷川悦雄, 小松晃之, 西出宏之, 土田英俊

    錯体化学討論会講演要旨集,錯体化学研究会  1990.10 

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  • 両面フェンスポルフィナト金属錯体の軸配位構造

    中田大作, 小松晃之, 長谷川悦雄, 西出宏之, 土田英俊

    錯体化学討論会講演要旨集,錯体化学研究会  1990.10 

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  • 両面修飾ヘムCO配位反応の動力学的解析

    小松晃之, 長谷川悦雄, 西出宏之, 土田英俊

    錯体化学討論会講演要旨集,錯体化学研究会  1990.10 

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  • α4β4置換、α4置換ポルフィナート鉄錯体配位挙動

    長谷川悦雄, 中尾啓輔, 小松晃之, 西出宏之, 土田英俊

    高分子学会予稿集,高分子学会  1990.5 

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  • オクタ置換ヘム（メソ-テトラ(2',6'-ジピバロイルオキシ)フェニルポルフィナト鉄）錯体のメスバウアースペクトルと配位構造

    中田大作, 小松晃之, 長谷川悦雄, 西出宏之, 土田英俊

    高分子学会予稿集,高分子学会  1990.5 

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  • Oxygenation of Octapivaloyloxyphenylporphinato-Iron and -Cobalt Complexes

    T. Komatsu, E. Hasegawa, H. Nishide, E. Tsuchida

    The 1989 International Chemical Congress of Pacific Basin Societies, Honolulu (USA)  1989.12 

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Research Projects

  • サイトカインストーム制圧を目指したマクロファージ標的化一酸化炭素ナノ供与体の創製

    Grant number：22H03959  2022.4 - 2026.3

    日本学術振興会  科学研究費助成事業  基盤研究(B)  慶應義塾大学

    田口 和明, 小松 晃之

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    Authorship：Coinvestigator(s) 

    Grant amount： \17420000 （ Direct Cost: \13400000 、 Indirect Cost： \4020000 ）

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  • Innovative Research of Neuroprotection for Delayed Cerebral Ischemia Associated with Cerebral Vasospasm after Subarachnoid Hemorrhage using Novel Hemoglobin-based Oxygen Carrier

    Grant number：22K09275  2022.4 - 2025.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)  Hokkaido University

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    Authorship：Coinvestigator(s) 

    Grant amount： \4160000 （ Direct Cost: \3200000 、 Indirect Cost： \960000 ）

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  • 人工酸素運搬体を用いたmulti-targetの脳保護療法の開発

    Grant number：22K09224  2022.4 - 2025.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)  北海道大学

    鐙谷 武雄, 藤村 幹, 伊東 雅基, 小松 晃之, 川堀 真人

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    Authorship：Coinvestigator(s) 

    Grant amount： \4160000 （ Direct Cost: \3200000 、 Indirect Cost： \960000 ）

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  • Synthesis of Protein/Polymer Hybrid Microtubes with Virus Capturing Ability

    Grant number：21H01767  2021.4 - 2024.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)  Chuo University

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    Authorship：Principal investigator 

    Grant amount： \17420000 （ Direct Cost: \13400000 、 Indirect Cost： \4020000 ）

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  • ヘモグロビンナノ粒子からなる人工酸素運搬体の開発

    2020.4 - 2023.3

    日本私立学校振興・共済事業団  学術研究振興資金 

    小松晃之

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    Authorship：Principal investigator  Grant type：Competitive

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  • 呼吸器外科手術への人工酸素運搬体ヘモアクトの応用

    2020.4 - 2023.3

    日本学術振興会  科学研究費補助金－基盤研究(C) 

    河野光智

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    Authorship：Coinvestigator(s)  Grant type：Competitive

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  • 抗酸化作用を付与した人工酸素運搬体による脳梗塞治療法の開発

    2019.4 - 2022.3

    日本学術振興会  科学研究費補助金－基盤研究(C) 

    鐙谷武雄

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    Authorship：Coinvestigator(s)  Grant type：Competitive

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  • 酵素反応のバブル噴射で自走する蛋白質マイクチューブモーターの創製とウイルス捕集

    2018.4 - 2021.3

    日本学術振興会  科学研究費補助金－基盤研究(B) 

    小松晃之

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    Authorship：Principal investigator  Grant type：Competitive

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  • 組換え(ヘモグロビン-アルブミン)ナノクラスターからなる人工酸素運搬体の創製

    2018.7 - 2020.3

    日本学術振興会  科学研究費補助金－挑戦的萌芽研究 

    小松晃之

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    Authorship：Principal investigator  Grant type：Competitive

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  • 冷却人工酸素運搬体の経動脈選択的投与による脳保護療法の開発

    2016.4 - 2019.3

    日本学術振興会  科学研究費補助金－基盤研究(C) 

    鐙谷武雄

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    Authorship：Coinvestigator(s)  Grant type：Competitive

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  • 自走する蛋白質マイクチューブの創製とウイルス・バクテリア捕集

    2015.4 - 2018.3

    日本学術振興会  科学研究費補助金－基盤研究(B) 

    小松晃之

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    Authorship：Principal investigator  Grant type：Competitive

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  • 完全合成型人工酸素運搬体としての組換え(ヘモグロビン-アルブミン)クラスターの開発

    2016.4 - 2017.3

    内藤記念科学振興財団  内藤記念科学奨励金・研究助成 

    小松晃之

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    Authorship：Principal investigator  Grant type：Competitive

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  • 蛋白質マイクロチューブを用いた大腸菌トラップの創製

    2014.4 - 2016.3

    文部科学省  科学研究費助成事業－挑戦的萌芽研究 

    小松晃之

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    Authorship：Principal investigator  Grant type：Competitive

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  • バイオ超分子マテリアル三次元構造解析装置

    2013.4 - 2014.3

    文部科学省  私立学校施設整備費補助金 

    小松晃之

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    Authorship：Principal investigator  Grant type：Competitive

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  • 蛋白質ナノチューブを用いた機能分子システムの創製

    2009.4 - 2014.3

    文部科学省  科学研究費補助金 新学術領域研究（配位プログラミング） 

    小松晃之

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    Authorship：Principal investigator  Grant type：Competitive

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  • (ヘモグロビン-アルブミン)クラスターからなる人工酸素運搬体の開発

    2012.4 - 2013.3

    科学技術振興機構  研究成果展開事業 研究成果最適展開支援プログラム（A-STEP） 

    小松晃之

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    Authorship：Principal investigator  Grant type：Competitive

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  • 蛋白質ヘテロクラスターからなる人工酸素運搬体の開発

    2011.4 - 2012.3

    東京応化技術振興財団  第25回研究費の助成 

    小松晃之

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    Authorship：Principal investigator  Grant type：Competitive

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  • 人工赤血球のICU使用を目的とした最適化およびME技術の改良

    2009.4 - 2011.3

    厚生労働省  厚生労働省科学研究費補助金 

    武田純三

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    Grant type：Competitive

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  • 内孔径を広狭調節できる蛋白質ナノチューブの創製と分子包接ダイナミクス

    2008.4 - 2011.3

    日本学術振興会  科学研究費補助金－基盤研究(Ｂ) 

    小松晃之

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    Authorship：Principal investigator  Grant type：Competitive

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  • 蛋白質ナノチューブを用いたバイオ超分子の創製

    2006.10 - 2010.3

    科学技術振興機構  戦略的創造研究推進事業－さきがけ（構造制御と機能） 

    小松晃之

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    Authorship：Principal investigator  Grant type：Competitive

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  • 血液製剤安定確保のための人工酸素運搬体を用いた緊急医療への応用に関する研究

    2006.4 - 2008.3

    厚生労働省  厚生労働省科学研究費補助金 

    四津良平

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    Grant type：Competitive

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  • 酸素輸送合成ヘム蛋白質(組換えアルブミン-ヘム錯体)の創製と結晶構造解析

    2005.4 - 2007.3

    日本学術振興会  二国間交流事業共同研究補助金－日英共同研究 

    小松晃之

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    Authorship：Principal investigator  Grant type：Competitive

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  • 組換えアルブミン－プロトヘム錯体から成る酸素輸送合成ヘム蛋白質の創製

    2004.4 - 2007.3

    日本学術振興会  科学研究費補助金－基盤研究(B) 

    小松晃之

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    Authorship：Principal investigator  Grant type：Competitive

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  • 32個の活性中心を有する星型ヘム蛋白質の創製と高濃度酸素輸送

    2004.4 - 2006.3

    文部科学省  科学研究費補助金－挑戦的萌芽研究 

    小松晃之

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    Authorship：Principal investigator  Grant type：Competitive

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  • 緊急・災害医療に利用可能な人工赤血球に関する研究

    2003.4 - 2006.3

    厚生労働省  厚生労働省科学研究費補助金 

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    Grant type：Competitive

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  • ポルフィリン・クロリン共組織体の構築と光照射による酸素配位能復活に関する研究

    2001.4 - 2003.3

    日本学術振興会  科学研究費補助金－基盤研究(C) 

    小松晃之

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    Authorship：Principal investigator  Grant type：Competitive

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  • ポルフィリン分子繊維の形成と光子注入によるその電子過程制御

    1999.4 - 2001.3

    日本学術振興会  科学研究費補助金－基盤研究(C) 

    小松晃之

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    Authorship：Principal investigator  Grant type：Competitive

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  • One-Step Multi-electron Transfer for Molecular Conversion

    Grant number：08044174  1996 - 1998

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for international Scientific Research  Waseda University

    TSUCHIDA Eishun, OYAIZU Kenichi, KOMATSU Teruyuki, NISHIDA Hiroyuki, ANSON Fred C, MIYATAKE Kenji

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    Grant amount： \16000000 （ Direct Cost: \16000000 ）

    The research project aims at elucidating the multi-electron transfer process of oxygen molecules incorporated into the macromolecule-metal complexes, in order to establish novel molecular conversion processes which are promoted by the four-electron reduction of oxygen.
    Followings have been established : Detailed analysis of the oxygen splitting reaction by one-step four-electron transfer, establishment of oxidative polymerization facilitated by multi-electron transfer process, elucidation of multi-electron transfer process in molecular assemblies. Based on these results, a general strategy to allow molecular conversions to proceed efficiently by multi-electron transfer process has been provided.
    1. Multi-nuclear metal complexes that show one-step multi-electron transfer processes were synthesized and their structure was determined. A general method to provide a one-step multi-electron transfer was provided.
    2. Oxygen splitting reaction by way of a μ-dioxo intermediate MOM-OO-MOM was established.
    3. Synthesis of novel compounds, polysulfoniums and polythioethers, were established, and their properties were determined in detail.
    4. Structure and properties of molecular assembly systems were elucidated, in terms of photoelectron transfer process.
    5. Synthesis of high molecular-weight polyheteroacenes were established, and their physicochemical properties were determined.

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  • 分子集合系における金属ポルフィリンの電子過程

    1995.4 - 1997.3

    日本学術振興会  科学研究費補助金－奨励研究 

    小松晃之

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    Authorship：Principal investigator  Grant type：Competitive

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  • ヘム誘導体の集合組織と酸素配位の動特性

    1993.10 - 1995.3

    日本学術振興会  科学研究費補助金－奨励研究 

    小松晃之

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    Authorship：Principal investigator  Grant type：Competitive

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Intellectual property rights

  • ポリオキサゾリン結合アルブミン、人工血漿増量剤及び出血ショックの蘇生液

    岡本 航、臼井 朝音

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    Application no：（US） 18/547504  Date applied：2022.2.28

    Announcement no：US-2024-0189432-A1  Date announced：2024.6.13

    Applicant (Organization)：学校法人中央大学

  • ポリオキサゾリン結合アルブミン、人工血漿増量剤及び出血ショックの蘇生液

    岡本 航、臼井 朝音

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    Application no：（DE） 11 2022 001 210.2  Date applied：2022.2.28

    Announcement no：（DE） 11 2022 001 210  Date announced：2024.1.11

    Applicant (Organization)：学校法人中央大学

  • ポリオキサゾリン結合アルブミン、人工血漿増量剤及び出血ショックの蘇生液

    岡本 航,臼井 朝音

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    Application no：PCT/JP2022/006785  Date applied：2022.2.18

    Announcement no：WO 2022/181505  Date announced：2022.9.1

    Applicant (Organization)：学校法人中央大学

  • ポリオキサゾリン結合アルブミン、人工血漿増量剤及び出血ショックの蘇生液

    岡本 航、臼井 朝音

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    Application no：特願2021-027892  Date applied：2021.2.24

    Announcement no：特開2022-129250  Date announced：2022.9.5

    Applicant (Organization)：学校法人中央大学

  • ヘモグロビン微粒子及び人口酸素運搬体

    岡本 航

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    Application no：特願2020-034372  Date applied：2020.2.28

    Announcement no：特開2021-134199  Date announced：2021.9.13

    Applicant (Organization)：学校法人中央大学

  • ポリオキサゾリン結合ヘモグロビン及び人口酸素運搬体

    森田 能次

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    Application no：特願2019-045253  Date applied：2019.3.12

    Announcement no：特開2020-147515  Date announced：2020.9.17

    Registration no：特許第7385234号  Date registered：2023.11.14 

    Applicant (Organization)：学校法人中央大学

  • 虚血性疾患の治療剤

    船木 亮佑,鐙谷 武雄,月花 正幸,寳金 清博

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    Application no：PCT/JP2017/024857  Date applied：2017.7.6

    Announcement no：WO2018/008729  Date announced：2018.1.11

    Applicant (Organization)：学校法人中央大学、国立大学法人北海道大学

  • 虚血性疾患の治療剤

    船木 亮佑,鐙谷 武雄,月花 正幸,寳金 清博

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    Application no：特願2018-526445  Date applied：2017.7.6

    Registration no：特許第7016124号  Date registered：2022.1.27 

    Applicant (Organization)：学校法人中央大学,国立大学法人北海道大学

  • 遺伝子組換え動物血清アルブミン、ヘモグロビン－遺伝子組換え動物血清アルブミン複合体、人工血漿増量剤及び人工酸素運搬体

    秋山 元英,山田 佳奈

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    Application no：PCT/JP2016/001655  Date applied：2016.3.22

    Announcement no：WO 2016/152150  Date announced：2016.9.29

    Applicant (Organization)：学校法人中央大学

  • 遺伝子組換え動物血清アルブミン、ヘモグロビン－遺伝子組換え動物血清アルブミン複合体、人工血漿増量剤及び人工酸素運搬体

    秋山 元英,山田 佳奈

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    Application no：特願2015-60030  Date applied：2015.3.23

    Announcement no：特開2016-179951  Date announced：2016.10.13

    Applicant (Organization)：学校法人中央大学

  • ヘモグロビン-アルブミン複合体、並びに該複合体を含む人工血漿増量剤及び人工酸素運搬体

    冨田 大樹

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    Application no：特願2013-502176  Date applied：2012.2.20

    Announcement no：再公表2012-117688  Date announced：2014.7.7

    Registration no：特許第6083674号  Date registered：2017.2.3 

    Applicant (Organization)：学校法人中央大学

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