Language：Japanese   Publishing type：Research paper (scientific journal)  

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Language：Japanese  

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：the American Pharmacists Association  

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：John Wiley & Sons  

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：AMER SOC MICROBIOLOGY  

In this work, we compared the profile of proteins secreted by planktonic and biofilm cultures of Pseudomonas aeruginosa using two-dimensional difference gel electrophoresis (2D-DiGE). This revealed that a novel metzincin protease, Mep72, was secreted during biofilm growth. Subsequent Western blotting and reverse transcription-PCR (RT-PCR) analyses demonstrated that Mep72 was expressed only during biofilm growth. Mep72 has a tridomain structure comprised of a metzincin protease-like domain and two tandem carbohydrate-binding domains. Unlike the only other metzincin (alkaline protease; AprA) in P. aeruginosa, Mep72 is secreted through the type II pathway and undergoes processing during export. During this processing, the metzincin domain is liberated from the carbohydrate-binding domains. This processing may be self-catalyzed, since purified Mep72 autodegraded in vitro. This autodegradation was retarded in the presence of alginate (an extracellular matrix component of many P. aeruginosa biofilms). The expression of full-length mep72 in Escherichia coli was toxic. However, this toxicity could be alleviated by coexpression of mep72 with the adjacent gene, bamI. Mep72 and BamI were found to form a protein-protein complex in vitro. 2D-DiGE revealed that the electrophoretic mobility of several discrete protein spots was altered in the biofilm secretome of an mep72 mutant, including type III secretion proteins (PopD, PcrV, and ExoS) and a flagellum-associated protein (FliD). Mep72 was found to bind directly to ExoS and PcrV and to affect the processing of these proteins in the biofilm secretome. We conclude that Mep72 is a secreted biofilm-specific regulator that affects the processing of a very specific subset of virulence factors.

DOI： 10.1128/JB.02404-14

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：WILEY-BLACKWELL  

BACKGROUND: We evaluated the hemostatic efficacy of H12-(adenosine 5'-diphosphate [ADP])-liposomes in the setting of active liver bleeding in rabbits with dilutional thrombocytopenia after massive transfusion. STUDY DESIGN AND METHODS: Acute thrombocytopenia (platelet [PLT] count < 50 × 10(9) /L) was induced in rabbits by repeated blood withdrawal and isovolemic transfusion of autologous washed red blood cells. Liver hemorrhage was initiated by a penetrating liver injury. Subsequently, the animals received tamponade treatment for the liver hemorrhage for 5 minutes and were intravenously administered H12-(ADP)-liposomes with PLT-poor plasma (PPP), PLT-rich plasma (PRP), PPP alone, H12-(phosphate-buffered saline [PBS])-liposome/PPP, or H12-(ADP)-liposomes/PPP plus fibrinogen concentrate during the tamponade. RESULTS: Administration of H12-(ADP)-liposomes/PPP rescued 60% of the rabbits from the liver hemorrhage; PRP administration rescued 50%. In contrast, rabbits receiving PPP or H12-(PBS)-liposome/PPP achieved only 10 or 17% survival, respectively, for the first 24 hours. H12-(ADP)-liposomes/PPP as well as PRP consistently reduced bleeding volumes and shortened clotting times (CTs) in comparison to PPP administration. Specifically, bleeding volumes in the initial 5 minutes averaged 11 mL (H12-(ADP)-liposomes/PPP) and 17 mL (PRP) versus 30 mL (PPP; p < 0.05); CTs averaged 270 and 306 seconds versus 401 seconds (p < 0.05). H12-(ADP)-liposomes were observed at the bleeding site with thrombus formation, suggesting an induction of thrombi. Neither macro- nor microthrombi were detected in the lung, kidney, spleen, or liver in rabbits treated with H12-(ADP)-liposomes. Supplementation of fibrinogen to H12-(ADP)-liposomes/PPP did not significantly improve rabbit survival. CONCLUSIONS: H12-(ADP)-liposomes might be a safe and effective therapeutic tool during damage control surgery for trauma patients with acute thrombocytopenia and massive bleeding.

DOI： 10.1111/trf.12829

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER SCIENCE LONDON  

Matrix-assisted laser desorption/ ionisation spiral orbit-type time-of-flight mass spectrometry (MALDI-SpiralTOF) can analyse lipid profiles and characterise lipid structure. Imaging mass spectrometry (IMS) also provides distribution maps of selected m/z values. Here, we investigated triacylglycerol (TG) structure and distribution using these technologies to estimate mouse fatty liver. The distribution and intensity of the most intense mass spectrum ion was indicated by IMS at m/z 881.7 (52:2). Analysis using MS/MS showed a structural change between liver TG and dietary TG. These findings suggest that MALDI-SpiralTOF is a powerful tool for clinical screening and estimating fatty liver. (C) 2014 The Authors. Published by Elsevier B.V. on behalf of Federation of European Biochemical Society.

DOI： 10.1016/j.fob.2014.02.005

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：日本血液代替物学会  

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：日本ビタミン学会  

We investigated the effect of vitamin E isoforms on the glucose tolerance in high-fat-induced obese mice. Eighteen male C57BL/6J mice aged six weeks were divided into three groups and fed a high-fat diet without vitamin E (HF), HF supplemented with 0.1% α-tocopherol (α-Toc) or HF supplemented with 0.1% γ-tocotrienol (γ-T3) for ten weeks. Oral glucose tolerance and insulin tolerance were tested after nine weeks of experimental diet feeding. Although growth rate and food intake were not significantly different among the three groups, addition of γ-T3, but not α-Toc, improved glucose tolerance and insulin sensitivity induced by the high-fat diet in obese mice. Fasting insulin levels in the γ-T3 group were lower than those in other high-fat groups, and the level of insulin secretion following glucose loading was significantly higher in the γ-T3 group than in the HF group. Histological findings showed that islets of the γ-T3 group were sufficiently active to secrete insulin in spite of high-fat feeding. These results suggested that γ-T3, but not α-Toc, protected islets against lipotoxicity and could be effective in treating type 2 diabetes.

DOI： 10.20632/vso.86.12_671

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Other Link： http://search.jamas.or.jp/link/ui/2013130601

Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Tōkyō Mejikaru Byūsha  

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：WILEY-BLACKWELL  

. Background: We developed a fibrinogen ?-chain (dodecapeptide HHLGGAKQAGDV [H12])-coated, ADP-encapsulated liposome (H12-[ADP]-liposome) that accumulates at bleeding sites via interaction with activated platelets via glycoprotein IIbIIIa and augments platelet aggregation by releasing ADP. Objective: To evaluate the efficacy of H12-(ADP)-liposomes for treating liver hemorrhage in rabbits with acute thrombocytopenia. Methods: Thrombocytopenia (platelets &lt; 50 000 mu L-1) was induced in rabbits by repeated blood withdrawal (100 mL kg-1 in total) and isovolemic transfusion of autologous washed red blood cells. H12-(ADP)-liposomes with platelet-poor plasma (PPP), platelet-rich plasma (PRP), PPP, ADP liposomes with PPP or H12-(PBS)-liposomes/PPP, were administered to the thrombocytopenic rabbits, and liver hemorrhage was induced by penetrating liver injury. Results: Administration of H12-(ADP)-liposomes and of PRP rescued all thrombocytopenic rabbits from liver hemorrhage as a result of potent hemostasis at the liver bleeding site, although rabbits receiving PPP or ADP liposomes showed 20% survival in the first 24 h. Administration of H12-(ADP)-liposomes and of PRP suppressed both bleeding volume and time from the site of liver injury. H12-(phosphate-buffered saline)-liposomes lacking ADP also improved rabbit survival after liver hemorrhage, although their hemostatic effect was weaker. In rabbits with severe thrombocytopenia (25 000 platelets mu L-1), the hemostatic effects of H12-(ADP)-liposomes tended to be attenuated as compared with those of PRP treatment. Histologic examination revealed that H12-(ADP)-liposomes accumulated at the bleeding site in the liver. Notably, neither macrothombi nor microthrombi were detected in the lung, kidney or liver in rabbits treated with H12-(ADP)-liposomes. Conclusions: H12-(ADP)-liposomes appear to be a safe and effective therapeutic tool for acute thrombocytopenic trauma patients with massive bleeding.

DOI： 10.1111/j.1538-7836.2012.04889.x

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier GmbH  

Zoledronic acid (Zol) is the most potent inhibitor of bone resorption among the bisphosphonates and is commonly used for inhibiting bone metastasis. However, it remains unclear whether Zol provides a survival benefit. Recent findings indicate that epidermal growth factor (EGF) signaling is an important mediator of bone metastasis. Thus, we examined the combined effects of Zol and an EGF receptor-tyrosine kinase inhibitor, gefitinib, on the proliferation and invasion of a bone-seeking clone and the breast cancer cell line MDA-MB-231. Combined treatment with Zol and gefitinib synergistically inhibited both invasion and cell proliferation of the bone-seeking clone, but not those of the MDA-MB-231 cells. Two-dimensional difference gel electrophoresis and mass spectrometry demonstrated that stathmin was down-regulated during these cooperative effects. Stathmin is a signal transduction regulatory factor which plays an important role in cell division and malignant tumor development. Our data suggest that stathmin may be a promising target molecule for blocking bone metastasis of breast cancer. © 2012 Elsevier GmbH. All rights reserved.

DOI： 10.1016/j.jbo.2012.06.001

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：日本Shock学会  

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：日本Shock学会  

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：SPRINGER  

Background One problem with polypropylene mesh (PPM) used to repair abdominal wall hernias is dense adhesions to the visceral surface. The authors developed the biocompatible poly-l-lactic acid (PLLA) nanosheet (thickness &lt; 100 nm), which has the unique ability to adhere tightly to tissues but not to opposing tissues. This study investigated the antiadhesive and fixative characteristics of the PLLA nanosheet after placement of intraperitoneal onlay PPM (IPOM) overlaid with a PLLA nanosheet on intact peritoneum.
Methods The PLLA nanosheet was fabricated by the spin-coating method and peeling technique with polyvinyl alcohol (PVA) as a supporting film. Two 1.5-cm-square pieces of mesh were implanted on each peritoneal side of the midline incision. The mesh was fixed to the peritoneum with a suture and then overlaid with a 4-cm-square piece of Seprafilm or nanosheet. To examine the fixative property, mesh was overlaid with Seprafilm or nanosheet without a fixed suture. After 4 weeks, mesh adhesion, inflammatory reaction, fixation, and dislocation of mesh were evaluated.
Results Nanosheet-overlaid meshes were flexible and fit over the peritoneum. Adhesion was observed in 10% of the nanosheet-overlaid meshes and in 50% of the Seprafilm-overlaid meshes. The adhesion tenacity grade was significantly lower with the nanosheet-overlaid meshes (0.1 +/- A 0.1) than with the Seprafilm-overlaid meshes (1.0 +/- A 0.4) (p = 0.029), and the percentage of the adhesion area also was lower with the nanosheet-overlaid meshes (1.0 +/- A 1.0% vs 8.5 +/- A 3.2%; p = 0.037). The mean inflammatory cell counts were lower with the nanosheet-overlaid meshes (p = 0.0023). Regarding the fixative property, 37.5% of the nanosheet-overlaid meshes were fixated on the peritoneum, but no Seprafilm-overlaid mesh was fixated.
Conclusions Overlaying of a PLLA nanosheet was effective for adhesion prophylaxis of intraperitoneal mesh. It also may have a possible beneficial effect on fixation of mesh.

DOI： 10.1007/s00464-011-1745-7

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：日本家政学会  

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：防衛医科大学校雑誌編集委員会  

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：INFORMA HEALTHCARE  

Introduction. Acetamiprid is a potent and a relatively new neonicotinoid insecticide. Animal studies have indicated that it has a low toxicity to mammals. Despite wide usage, human exposure resulting in toxicity is quite limited, and this is the first report in the English literature about acute acetamiprid poisoning in humans. Case Details. We herein describe two cases of acute poisoning with an insecticide formulation containing acetamiprid for suicidal purposes. Both cases experienced severe nausea and vomiting, muscle weakness, hypothermia, convulsions, and clinical manifestations including tachycardia, hypotension, electrocardiogram changes, hypoxia, and thirst in the case with the higher serum concentration of acetamiprid. The symptoms were partially similar to acute organophosphate intoxication. Supportive treatments for a variety of symptoms were sufficient for recovery, and both individuals were discharged without any complications 2 days after ingestion.&lt;/.

DOI： 10.3109/15563650.2010.517207

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：The Hospital Infection Society  

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Blackwell Scientific Publications  

Many Gram-negative bacteria employ a mechanism of cell-cell communication known as quorum sensing (QS). The role of QS is to enable the cells in a culture to coordinate their gene expression profile with changes in the population cell density. The best characterized mechanisms of QS employ N-acylated homoserine lactones (AHLs) as signalling molecules. These AHLs are made by enzymes known as LuxI homologs, and accumulate in the culture supernatant at a rate proportional to the increase in cell density. Once the AHL concentration exceeds a certain threshold value, these ligands bind to intracellular receptors known as LuxR homologs. The latter are transcriptional regulators, whose activity alters upon binding the AHL ligand, thereby eliciting a change in gene transcription. Over the last five years, it has become increasingly obvious that this is a rather simplistic view of aHL-dependent QS, and that in fact, there is considerable diversity in the way in which LuxI-R homologs operate. The aim ofthe current review is to describe these variations on the basic theme, and to show how functional genomics is revolutionizing our understanding of QS-controlled regulons.

DOI： 10.3184/003685006783238335

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：PERGAMON-ELSEVIER SCIENCE LTD  

Chlamydomonas acidophila KT-1 and Chlamydomonas acidophila DVB238 exhibit a strong heavy metal tolerance, but C acidophila DVB238 can accumulate a much higher amount of Cadmium (Cd) than C. acidophila KT-1. Phytochelatins (PCs) are known to play an important role in the detoxification of several toxic heavy metals, but the relationship between PCs and Cd accumulation is not clear. PC metabolism and Cd accumulation were investigated by using three Chlamydomonas strains including Chlamydomonas reinhardtii C-9 as a standard alga. The results showed that the PC content did not correlate closely with the level of Cd accumulation, maintenance of a high GSH level seeming to be more important for Cd accumulation. The ultrastructure of C acidophila KT-1 was extremely disrupted by a great increase in starch granules, which resulted in a moribund state, but hyper-accumulator C acidophila DVB238 did not exhibit an increase in starch granules in its cells, in spite of Cd accumulation in its chloroplasts, cytosol and vacuoles. These results indicated that C acidophila DVB238 probably has a developed detoxification system preventing such as destruction of the cells due to Cd toxicity. (c) 2005 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.chemosphere.2005.09.056

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER IRELAND LTD  

In order to study the polyphosphate (PolyP) metabolism in the acidophilic alga, the effect of rapid change of external phosphate concentration (so-called Pi stress condition) on the distribution of PolyP in Chlamyclomonas acidophila KT-1 was investigated by fluorescent microscopy, in vivo P-31 NMR spectroscopy, and enzymatic quantification. The PolyP granules inside of C acidophila KT-I cells were observed by microscopy with a fluorescent dye 4',6-diarnidino-2-phenylindole (DAPI). Cells transferred from phosphate (Pi) deficient to Pi rich conditions were contained a large amount of PolyP and an additional new PolyP stain was observed around the cell surface. In comparison to a neutrophilic alga Chlamydomonas reinhardtii C-9, the total amount of PolyP in C. acidophila KT-1 was 2.5 times smaller. The lower content of PolyP in C. acidophila KT-1 was supposed to be attributable to the specific properties of its cell membrane, which limited to incorporate phosphate from the environment. Nevertheless, the trend of degradation and re-synthesis of PolyP in C. acidophila KT-1 was similar to that of C reinhardtii C-9 under Pi stress conditions with absolute PolyP amount being affected by the total phosphate in the cells. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

DOI： 10.1016/j.plantsci.2005.08.025

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：日本救急医学会関東地方会  

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER SCIENCE BV  

Ultrastructural changes induced by heavy metals (cadmium, zinc, and copper) and polyphosphate metabolism were studied in Chlamydomonas acidophila. Transmission electron microscopy indicated that cadmium led to the most drastic morphometric changes. An increase in number and volume of starch grains and vacuoles as well as the presence of electron dense deposits in vacuole and membrane whorls were observed. Energy-dispersive X-ray analysis revealed that vacuolar deposits inside cells treated with cadmium contained phosphate and cadmium. These ultrastructural changes were accompanied by a change in the intracellular polyphosphate level, as shown by in vivo P-31-nuclear magnetic resonance. It was also observed that cadmium treatment caused polyphosphate degradation and increased vacuolar short-chains and orthophosphates. (C) 2003 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.

DOI： 10.1016/S0168-6496(03)00049-7

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：TAYLOR & FRANCIS LTD  

An acidophilic volvocine flagellate, Chlamydomonas acidophila (Volvocales) that was isolated from an acid lake, Katanuma, in Miyagi prefecture, Japan was studied for growth, ultrastructural characterization, and metal tolerance. Chlamydomonas acidophila is obligately photoautotrophic, and did not grow in the cultures containing acetate or citrate even in the light. The optimum pH for growth was 3.5-4.5. To characterize metal tolerance, the toxic effects of Cd, Co, Cu, and Zn on this alga were also studied. Effective metal concentrations, which limited the growth by 50%, EC50 were measured, after 72 h of static exposure. EC(50)s were 14.4 mum Cd2+, 81.3 mum Co2+, 141 mum, Cu2+, and 1.16 mum Zn2+ for 72 h of exposure. Thus, this alga had stronger tolerance to these metals than other species in the genus Chlamydomonas.

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Language：Japanese   Publisher：(一社)日本血栓止血学会  

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Language：Japanese   Publisher：(一社)日本病理学会  

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Language：Japanese   Publisher：(公社)日本化学療法学会  

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Language：Japanese   Publisher：(一社)日本腹部救急医学会  

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Language：Japanese   Publisher：(一社)日本救急医学会  

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Language：Japanese   Publisher：(一社)日本救急医学会  

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Language：Japanese   Publisher：(一社)日本救急医学会  

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Language：Japanese   Publisher：(株)へるす出版  

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Language：Japanese   Publisher：(一社)日本輸血・細胞治療学会  

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Language：Japanese   Publisher：一般社団法人日本外科学会  

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Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (other)   Publisher：厚生労働科学研究費補助金創薬基盤推進研究事業平成25年度総括 p24-45  

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Language：Japanese   Publisher：(一社)日本外科学会  

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Language：Japanese   Publisher：日本血液代替物学会  

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Language：Japanese   Publisher：(一社)日本救急医学会  

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Language：Japanese   Publisher：(一社)日本生理学会  

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Language：Japanese   Publisher：東京 : シーエムシー出版  

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Other Link： https://ndlsearch.ndl.go.jp/books/R000000004-I024698281

Language：Japanese   Publisher：(公社)日本栄養・食糧学会  

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Language：Japanese   Publisher：(一社)日本血栓止血学会  

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Language：Japanese   Publisher：一般社団法人日本外科学会  

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Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (other)   Publisher：厚生労働科学研究費補助金創薬基盤推進研究事業平成24年度総括 p80-102  

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Language：Japanese   Publisher：(一社)日本外科学会  

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Language：Japanese   Publisher：(一社)日本防衛衛生学会  

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Language：Japanese   Publisher：一般社団法人日本外科学会  

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Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (other)   Publisher：厚生労働科学研究費補助金創薬基盤推進研究事業平成23年度総括 p24-38  

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Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (other)   Publisher：厚生労働科学研究費補助金創薬基盤推進研究事業平成21-23年度総括 p53-95  

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Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (other)   Publisher：厚生労働科学研究費補助金創薬基盤推進研究事業平成23年度総括  

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Language：English   Publishing type：Research paper, summary (international conference)   Publisher：LIPPINCOTT WILLIAMS & WILKINS  

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Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (other)   Publisher：厚生労働科学研究費補助金創薬基盤推進研究事業平成22年度総括p23-38  

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Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (other)   Publisher：厚生労働科学研究費補助金創薬基盤推進研究事業平成２１年度総括 p34-46  

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Publisher：The Japanese Society of Plant Physiologists  

Acidophilic algae, Chlamydomonas acidophila DVB 238 and Chlamydomonas acidophila KT-1, had very strong heavy metal tolerance in comparison with other neutrophilic algae. To explore the possibility for use of phytoremediation, two acidophilic algae were investigated the accumulation of metal (Cd and Ni) and the protein synthesis under various metal concentration.<br>C. acidophila DVB 238 showed higher accumulation (13.7 μg g Cd and 2.59 μg g Ni per 10⁸ cells) than C. acidophila KT-1. Moreover Cd treatment did not induce an increase of protein in C. acidophila KT-1 but C. acidophila DVB 238. Therefore these two strains seemed to have different system for accumulating Cd. So we detected changes in the soluble protein synthesis pattern by two-dimensional polyacrylamide gel electrophoresis for C. acidophila DVB 238 cells grown under different concentrations of Cd and Ni. Some of characteristic spots were analyzed by protein sequencer and MALDI-TOF Mass.

DOI： 10.14841/jspp.2005.0.409.0

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